Alia Alia
Assistant professor
- Name
- Dr. A. Alia
- Telephone
- +31 71 527 4623
- a.alia@chem.leidenuniv.nl
- ORCID iD
- 0000-0002-4900-9749
The main research focus of Alia is on developing and applying specific MR microimaging, localized spectroscopy, and HR-MAS NMR methods to investigate structural and neurochemical changes in the brain, including studying the early biomarkers and gender specific differences in Alzheimer's disease (AD) in mouse model. Cutting-edge MRI and NMR methods are also being developed to get direct molecular access to adult zebrafish as a versatile model for understanding a spectrum of human diseases. Additionally, exciting strides are being made in pioneering the application of HR-MAS NMR, specifically tailored to unravel the intricate effects of toxins and pollutants like Nanoplastics and PFAS on metabolic pathways and toxicity mechanisms.
Curriculum Vitae
- Since 2014: Group leader, Institut für Medizinische Physik und Biophysik, Leipzig University.
- Since 2007: Assistant Professor (tenure), Leiden Institute of Chemistry, Leiden University.
- 1997 - 2007: Scientific Researcher at Leiden Institute of Chemistry, Leiden University.
- 1996 - 1997: Japan Society for Promotion of Science (JSPS) fellow in the National Institute for Basic Biology, Okazaki, Japan.
- 1995 - 1996: COE visiting Professor in National Institute for Basic Biology, Okazaki, Japan.
- 1991 - 1995: Lecturer at Center for Biosciences, Jamia Millia University, New Delhi.
- 1992: Ph.D. Bioscience from Jamia Millia University, Delhi, India. (Subject: Mechanism of stress tolerance).
- 1989: M.Sc. Biosciences from Jamia Millia University, Delhi, India (first position in University).
- 1988: B.Ed. Education from Jamia Millia University, Delhi, India (first position in University).
- 1986: B.Sc. Life Sciences from University of Delhi, New Delhi, India.
Scientific honours (awards) received
- Alzheimer Forschung Initiative grant award (2013).
- FOM/ALW open competition grant award (2011).
- Internationale stichting Alzheimer onderzoek grant award (2007).
- C.J. Kok Prize for the discovery of the year 2003 from Faculty of Mathematics and Natural Sciences, University of Leiden (2004).
- Japan Society for Promotion of Science fellowship award (1996).
- A center-of-excellence grant award from the Monbusho, Japan (1995).
- Young scientist award, Department of Science & Technology (DST), Govt. of India (1993).
- Joint CSIR-UGC research fellowship & lecturership award (1989).
- Award of merit for getting first position in University in M.Sc. (1989).
- Award of merit for getting first position in University in B.Ed. (1988).
Grants received
- Project grant sanctioned by Alzheimer Forschung Initiative (AFI), for 3 years in 2013-2016. (Research Topic: In vivo MRI studies in assessment of sex-related metabolic changes in AD (PI) (€ 76.500).
- Project grant sanctioned by “The Netherlands Organization for Scientific Research (NWO)” within open competition from the division FOM/ALW for 5 years in 2011. (Research topic: Phenotypic engineering) (PI) (co-PI: HJM de Groot, BJ van der Zaal, PJJ Hooykaas) (€743.000).
- Project grant sanctioned by Centre for Medical System Biology (CMSB), one of the four Genomic Centres of Excellence of the Netherlands Genomics Initiative (NGI) for 4 years (2008). (Research Topic: Predicting Alzheimer's disease: diagnosis and prognosis) (PI) (€ 60.000).
- Project grant sanctioned by Internationale Stichting Alzheimer Onderzoek (ISAO), for 3 years in 2007. (Research Topic: In vivo mMRI and MRS studies in assessment of early biomarkers of AD) (PI) (€ 72.000).
- Research fellowship grant awarded by Japan Society for Promotion of Science (JSPS), Japan (1996). (Research Topic: Stress tolerance by engineering glycinebetaine biosynthetic pathway).
- A center-of-excellence research grant awarded by the Monbusho, Japan (1995). (Research Topic: Enhanced stress tolerance of Arabidopsis by expressing choline oxidase for betaine synthesis).
- Project grant sanctioned by Research Institute of Innovative Technology for the Earth (RITE), Japan, for 2 years in 1993. (Research Topic: Micropropagation of fast growing species with high CO2 assimilating potential) (co-PI with Prof. P. Pardha Saradhi and K.G. Mukerji).
- Young Scientist Project grant sanctioned by the Department of Science and Technology (DST), Govt. of India (India) for 2+1 years in 1993. (Research Topic: Molecular mechanism of proline induce stress tolerance) (PI).
Professional activities
- European Science Foundation Pool of Reviewers, 2012.
- Editorial board member of the Journal: ISRN Biomedical Imaging (Hindawi Pub.)
- Scientific co-organiser of Lorentz workshop “Hacking the biological clock” (Leiden, The Netherlands, April 10-13, 2012).
- Guest Editor for special issues in the journal “Current Medical Imaging Reviews” (Bentham Science Publishers) on “Prospects of magnetic resonance imaging for Alzheimer’s disease” (Issue February 2011).
- Guest Editor for special educational issue in “Photosynthetic Research” (Springer) on “Basics and application of biophysical techniques in photosynthesis” (Issues: September 2009 and November 2009).
- Frequent reviewer of: (a) grant proposal NWO/CW ECHO grants; (b) Alzheimer’s association grants; (c) ERC grants.
- Frequent reviewer for journals: Brain, Neuroimage, Neuroscience Letters, Current Medical Imaging Reviews, Free Radicals in Medicine, Photosynthesis research, Journal of Magnetic Resonance Imaging.
- Served as member of faculty for the ISN/ESN summer school “Advance Imaging and Biomarkers in Neurological Disorders”, Meißen, Germany (July 6-10, 2009).
- Scientific organiser of CMSB mini-symposium “Alzheimer’s disease: from biomarkers to common denominators” (Oegstgeest, The Netherlands, April 2006)
- Member of Ph.D. thesis promotion/opposition committee at Leiden University for 8 Ph.D. students (since 2006).
- Supervision/co-promotor of 5 Ph.D. projects at Leiden University, Leiden, The Netherlands, since 2004.
- Honorary lecturer at the Center for Biosciences, Jamia Millia University, New Delhi, India (during academic session 1994-95).
- Subject expert for making TV programs on “plasma membrane” for UGC Educational Telecast (1993-95).
Memberships
- Member of “International Society for Magnetic Resonance in Medicine (ISMRM)” since 2006.
- Member of “European Society for Magnetic Resonance in Medicine and Biology (ESMRMB)” since 2013.
- Member of “International Society to Advance Alzheimer Research and Treatment (ISTAART)” since 2008.
- Member of “Alzheimer Research Forum” since 2005.
Key publications
- Roy, U., Stute, L., Höfling, C., Hartlage-Rübsamen, M., Matysik, J., Rossner, S., Alia, A. Sex and Age specific Modulation of brain GABA Levels in a mouse model of Alzheimer's disease. Neurobiology of Aging 62 (2018) 168-179. DOI
- Roy, U., Conklin, L., Schiller, J., Matysik, J., Berry, J.P., Alia, A. Metabolic profiling of zebrafish embryos by NMR spectroscopy reveals multifaceted neurotoxicity of beta-methylamino-L-alanine (BMAA). Scientific Reports 7 (2017) e17305. DOI
- Kara F., Chen F., Ronen I., de Groot H.J.M., Matysik J., Alia A. In vivo measurement of transverse relaxation time in the mouse brain at 17.6T. Mag. Res.Med. 70 (2013) 985-993. DOI
- Haud N., Kara F., Diekmann S., Henneke, M., Willer J., Hillwig M.H., Gregg R.B., MacIntosh G.C., Gartner J., Alia A., Hurlstone A.F.L. RNase T2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proc. Natl. Acad. Sci. USA 108 (2011) 1099-1103. DOI
- Diller A., Roy E., Gast P., van Gorkom H.J., de Groot H.J.M., Glaubitz C., Jeschke G., Matysik J., Alia A. 15N photochemically induced dynamic nuclear polarization magic-angle spinning NMR analysis of the electron donor of photosystem II. Proc. Nat. Acad. Sci. (USA) 104 (2007) 12767-12771. DOI
Assistant professor
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Macromolecular Biochemistry
- Bashirova N., Schölzel F., Hornig D., Scheidt H.A., Krueger M., Salvan G., Huster D., Matysik J. & Alia A. (2025), The effect of polyethylene terephthalate nanoplastics on Amyloid-β Peptide Fibrillation, Molecules 30(7): 1432.
- Kim Y., Alia A., Kurle-Tucholski P., Wiebeler C. & Matysik J. (2024), Electronic structures of radical-pair-forming cofactors in a heliobacterial reaction center, Molecules 29(5): 1021.
- Annunziato M., Bashirova N., Eeza M.N.H., Lawson A., Fernandez‐Lima F., Tose L.V., Matysik J., Alia A. & Berry J.P. (2024), An integrated metabolomics-based model, and identification of potential biomarkers, of perfluorooctane sulfonic acid toxicity in zebrafish embryos, Environmental Toxicology and Chemistry 43(4): 896-914.
- Singer R., Oganezova I., Hu W., Liu L., Ding Y., Groot H.J.M. de, Spaink H.P. & Alia A. (2024), Ultrahigh field diffusion magnetic resonance imaging uncovers intriguing microstructural changes in the adult zebrafish brain caused by Toll‐like receptor 2 genomic deletion, NMR in Biomedicine 37(10): e5170.
- Bashirova N., Butenschön E., Poppitz D., Gaß H., Halik M., Dentel D., Tegenkamp C., Matysik J. & Alia. A. (2024), Magnetic resonance imaging-based monitoring of the accumulation of polyethylene terephthalate nanoplastics, Molecules 29(18): 4380.
- Singer R., Oganezova I., Hu W., Ding Y., Papaioannou A., Groot H.J.M. de, Spaink H.P. & Alia A. (2024), Unveiling the exquisite microstructural details in Zebrafish brain non-invasively using magnetic resonance imaging at 28.2 T, Molecules 29(19): 4637.
- Lawson A., Annunziato M., Bashirova N., Eeza M.N.H., Matysik J., Alia A. & Berry J.P. (2024), High-resolution magic-angle spinning nuclear magnetic resonance identifies impairment of metabolism by T-2 toxin, in relation to toxicity, in Zebrafish embryo model, Toxins 16(10): 424.
- Kim Y., Gräsing D., Alia A., Wiebeler C. & Matysik J. (2024), Solid-state NMR analysis of the dynamics of cofactors: comparison of Heliobacterial and purple bacterial reaction centers, The Journal of Physical Chemistry B 128(47): 11525-11545.
- Annunziato M., Bashirova N., Eeza M.N.H., Lawson A., Benetti D., Stieglitz J.D., Matysik J., Alia. A. & Berry J.P. (2023), High-resolution magic angle spinning (HRMAS) NMR identifies oxidative stress and impairment of energy metabolism by zearalenone in embryonic stages of zebrafish (Danio rerio), olive flounder (Paralichthys olivaceus) and yellowtail snapper (Ocyurus chrysurus), Toxins 15(6): 397.
- Bashirova N., Poppitz D., Klüver N., Scholz S., Matysik J. & Alia A. (2023), A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo, Scientific Reports 13(1): 1891.
- Hu W., Liu L., Forn-Cuní G., Ding Y., Alia A. & Spaink H.P. (2023), Transcriptomic and metabolomic studies reveal that toll-like receptor 2 has a role in glucose-related metabolism in unchallenged zebrafish larvae (Danio rerio), Biology 12(2): 323.
- Eeza M.N.H., Singer R., Ding Y., He J., Zuberi Z., Baelde H.J., Groot H.J.M. de, Matysik J., Spaink H.P. & Alia A. (2023), Probing microstructural changes in muscles of leptin-deficient zebrafish by non-invasive ex-vivo magnetic resonance microimaging, PLoS ONE 18(4): e0284215.
- Matysik J., Ding Y.H., Kim Y., Kurle P., Yurkovskaya A., Ivanov K. & Alia A. (2022), Photo-CIDNP in solid state, Applied Magnetic Resonance 53: 521-537.
- Annunziato M., Eeza M.N.H., Bashirova N., Lawson A., Matysik J., Benetti D., Grosell M., Stieglitz J.D., Alia A. & Berry J.P. (2022), An integrated systems-level model of the toxicity of brevetoxin based on high-resolution magic-angle spinning nuclear magnetic resonance (HRMAS NMR) metabolic profiling of zebrafish embryos, Science of the Total Environment 803: 149858.
- Eeza M.N.H., Bashirova N., Zuberi Z., Matysik J., Berry J.P. & Alia A. (2022), An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling, Scientific Reports 12: 6341.
- Alia A. & Singer R. (2022), Evaluation of suprachiasmatic nucleus in Alzheimer’s disease with non-invasive magnetic resonance methods, Neural Regeneration Research 17(8): 1753-1754.
- Ding Y., Haks M.C., Eeden S.J.F. van den, Ottehoff T.H.M., Harms A.C., Hankemeier T., Eeza M.N.H., Matysik J., Alia A. & Spaink H.P. (2022), Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome, Metabolomics 18(8): 67.
- Schadewijk R. van, Krug J.R., Webb A., As H. van, Velders A.H., Groot H.J.M. de & Alia A. (2021), MRM microcoil performance calibration and usage demonstrated on Medicago truncatula roots at 22 T, Journal of visualized experiments 167: e61266.
- Augustijn D., Groot H.J.M. de & Alia A. (2021), HR-MAS NMR applications in plant metabolomics, Molecules 26(4): 931.
- He J., Ding Y., Nowik N., Jager C., Eeza M.N.H., Alia A., Baelde H.J. & Spaink H.P. (2021), Leptin deficiency affects glucose homeostasis and results in adiposity in zebrafish, Journal of Endocrinology 249(2): 125-134.
- Ding Y., Haks M.C., Forn Cuní G., He J., Nowik N., Harms A.C., Hankemeier T., Eeza M.N.H., Matysik J., Alia A. & Spaink H.P. (2021), Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways, Cell & Bioscience 11(1): 126.
- Eezaa M.N.H., Singer R., Höfling C., Matysik J., Groot H.J.M. de, Roβner S. & Alia A. (2021), Metabolic profiling of suprachiasmatic nucleus reveals multifaceted effects in an Alzheimer's disease mouse model, Journal of Alzheimer's Disease 81(2): 797-808.
- Kettwig M., Ternka K., Wendland K., Krüger D.M., Zampar S., Schob C., Franz J., Aich A., Winkler A., Sakib M.S., Kaurani L., Epple R., Werner H.B., Hakroush S., Kitz J., Prinz M., Bartok E., Hartmann G., Schröder S., Rehling P., Henneke M., Boretius S., Alia A., Wirths O., Fischer A., Stadelmann C., Nessler S. & Gärtner J. (2021), Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy, Nature Communications 12: 6530.
- Schadewijk R. van, Krug J.R., Shen D., Sai Sankar Gupta K.B., Vergeldt F.J., Bisseling T., Webb A., As H. van, Velders A.H., Groot H.J.M. de & Alia A. (2020), Magnetic Resonance Microscopy at Cellular Resolution and Localised Spectroscopy of Medicago truncatula at 22.3 Tesla, Scientific Reports 10: 971.
- Gebreab K.Y., Eeza M.N.H., Bai T., Zuberi Z., Matysik J., O'Shea K.E., Alia A. & Berry J.P. (2020), Comparative toxicometabolomics of perfluorooctanoic acid (PFOA) and next-generation perfluoroalkyl substances, Environmental Pollution 265(Part A): 114928.
- Krug J.R. Schadewijk R. van Vergeldt F.J. Webb A.G. Groot H.J.M. de Alia A. As H. van Velders A.H. (2020), Assessing spatial resolution, acquisition time and signal-to-noise ratio for commercial microimaging systems at 14.1, 17.6 and 22.3 T, Journal of Magnetic Resonance 316: 106770.
- Ding Y. Raterink R. Marín‑Juez R. Veneman W.J. Egbers K. Eeden S. van den Haks M.C. Joosten S.A. Ottenhof T.H.M. Harms A.C. Alia A. Hankemeier T. Spaink H.P. (2020), Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria‑infected mice and zebrafish larvae, Scientific Reports 10: 11635.
- Janssen G.J., Eschenbach P., Kurle P., Bode B.E., Neugebauer J., Groot H.J.M. de, Matysik J. & Alia A. (2020), Analysis of the electronic structure of the primary electron donor of photosystem I of Spirodela oligorrhiza by photo-CIDNP solid-state NMR, Magnetic Resonance 1(2): 261–274.
- Roy U., Heredia-Munoz M.T., Stutea L., Hofling C., Matysik J., Meijer J.H., Rossner S. & Alia A. (2019), Degeneration of the suprachiasmatic nucleus in an Alzheimer's disease mouse model monitored by in vivo magnetic resonance relaxation measurements and immunohistochemistry, Journal of Alzheimer's Disease 69(2): 363-375.
- Bielytskyi P., Gräsing D., Zahn S., Alia A. & Matysik J. (2019), 15N–1H Transfer of Light-Induced Nuclear Hyperpolarization in Frozen Photosynthetic Reaction Centers, Applied Magnetic Resonance 50(5): 695–708.
- Zuberi Z., Eeza M.N.H., Matysik J., Berry J.P. & Alia A. (2019), NMR-Based Metabolic Profiles of Intact Zebrafish Embryos Exposed to Aflatoxin B1 Recapitulates Hepatotoxicity and Supports Possible Neurotoxicity, Toxins 11(5): 258.
- Augustijn D., Groot H.J.M. de & Alia A. (2019), A robust circadian rhythm of metabolites in Arabidopsis thaliana mutants with enhanced growth characteristics, PLoS ONE 14(6): e0218219.
- Gräsing D., Dziubińska-Kühn K.M., Zahn S., Alia A. & Matysik J. (2019), Studying hydrogen bonding and dynamics of the acetylate groups of the Special Pair of Rhodobacter sphaeroides WT, Scientific Reports 9(1): 10528.
- Zill J.C., Kansy M., Goss R., Alia A., Wilhelm C. & Matysik J. (2019), N-15 photo-CIDNP MAS NMR on both photosystems and magnetic field-dependent C-13 photo-CIDNP MAS NMR in photosystem II of the diatom Phaeodactylum tricornutum, Photosynthesis Research 140(2): 151-171.
- Pérez-Rius C., Folgueira M., Elorza-Vidal X., Alia A., Hoegg-Beiler M.B., Eeza M.H.B., Luz Díaz M., Nunes V., Barrallo-Gimeno A. & Estévez R. (2019), Comparison of zebrafish and mice knockouts for megalencephalic leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit, Orphanet Journal of Rare Diseases 14: 268.
- Paul S., Roy U., Böckers M., Neugebauer J., Alia A. & Matysik J. (2019), 15N photo-CIDNP MAS NMR analysis of a bacterial photosynthetic reaction center of rhodobacter sphaeroides wildtype, The Journal of Chemical Physics 151: 195101.
- Zill J.C., Kansy M., Goss R., Alia A., Wilhelm C. & Matysik J. (2019), 15N photo-CIDNP MAS NMR on both photosystems and magnetic fielddependent 13C photo-CIDNP MAS NMR in photosystem II of the diatom Phaeodactylum tricornutum, Photosynthesis Research 140(2): 151-171.
- Bielytskyi P., Gräsing D., Zahn S., Mote K.R., Alia A., Madhu P.K. & Matysik J. (2019), Assignment of NMR resonances of protons covalently bound to photochemically active cofactors in photosynthetic reaction centers by 13C–1H photo-CIDNP MAS-J-HMQC experiment, Journal of Magnetic Resonance 298: 64-76.
- Najdanova M., Grasing D., Alia A. & Matysik J. (2018), Analysis of the electronic structure of the special pair of a bacterial photosynthetic reaction center by (13) C photochemically induced dynamic nuclear polarization magic-angle spinning NMR using a double-quantum axis, Photochemistry and Photobiology 94(1): 69-80.
- Roy U., Stute L., Höfling C., Hartlage-Rübsamen M., Matysik J., Roβner S. & Alia A. (2018), Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease, Neurobiology of Aging 62: 168-179.
- Chiziane E., Telemann H., Krueger M., Adler J., Arnhold J., Alia A. & Flemmig J. (2018), Free heme and amyloid-β: a fatal liaison in Alzheimer's disease, Journal of Alzheimer's Disease 61(3): 963-984.
- Zill J.C., He Z., Tank M., Ferlez B.H., Canniffe D.P., Lahav Y., Bellstedt P., Alia A., Schapiro I., Golbeck J.H., Bryant D.A. & Matysik J. (2018), 15N photo-CIDNP MAS NMR analysis of reaction centers of Chloracidobacterium thermophilum, Photosynthesis Research 137(2): 295-305.
- Schadewijk R. van, Berg T.E. van den, Sai Sankar Gupta K.B., Ronen I., Groot H.J.M. de & Alia A. (2018), Non-invasive magnetic resonance imaging of oils in Botryococcus braunii green algae: Chemical shift selective and diffusion-weighted imaging, 13(8): e0203217.
- Alia A. & Roßner S. (2018), Gender, GABAergic dysfunction and AD, Aging 10(12): 3636-3637.
- Bielytskyi P., Gräsing D., Mote K.R., Sai Sankar Gupta K.B., Vega S., Madhu P.K., Alia A. & Matysik J. (2018), 3C → 1H transfer of light-induced hyperpolarization allows for selective detection of protons in frozen photosynthetic reaction center, Journal of Magnetic Resonance 293: 82-91.
- Flemmig J., Zamocky M. & Alia A. (2018), Amyloid beta and free heme: bloody new insights into the pathogenesis of Alzheimer's disease, Neural Regeneration Research 13(7): 1170-1174.
- Janssen G.J., Bielytskyi P., Artiukhin D.G., Neugebauer J., Groot H.J.M. de, Matysik J. & Alia A. (2018), Photochemically induced dynamic nuclear polarization NMR on photosystem II: donor cofactor observed in entire plant, Scientific Reports 8: 17853.
- Augustijn D., Tol N.V. van, Zaal E.J. van der, Groot H.J.M. de & Alia A. (2018), High-resolution magic angle spinning NMR studies for metabolic characterization of Arabidopsis thaliana mutants with enhanced growth characteristics, PLoS ONE 13(12): e0209695.
- Zill J.C., Kansy M., Goss R., Köhler L., Alia A., Wilhelm C. & Matysik J. (2017), Photo-CIDNP in the reaction center of the diatom Cyclotella meneghiniana observed by 13C MAS NMR, Zeitschrift für Physikalische Chemie 231(2): 347-367.
- Tol N. van, Rolloos A.M., Augustijn D., Alia A., Groot H.J.M. de, Hooykaas P.J.J. & Zaal E.J. van der (2017), An Arabidopsis mutant with high operating efficiency of Photosystem II and low chlorophyll fluorescence, Scientific Reports 7: 3314.
- Gräsing D., Bielytskyi P., Cépedes-Camacho I.F., Alia A., Marquardsen T., Engelke F. & Matysik J. (2017), Field-cycling NMR with high-resolution detection under magic-angle spinning: determination of field-window for nuclear hyperpolarization in a photosynthetic reaction center, Scientific Reports 7(1): 12111.
- Roy U., Conklin L., Schiller J., Matysik J., Berry J.P. & Alia A. (2017), Metabolic profiling of zebrafish (Danio rerio) embryos by NMR spectroscopy reveals multifaceted neurotoxicity of beta-methylamino-L-alanine (BMAA), Scientific Reports 7: 17305.
- Augustijn D., Roy U., Schadewijk R. van, Groot H.J.M. de & Alia A. (2016), Metabolic Profiling of Intact Arabidopsis thaliana Leaves during Circadian Cycle Using 1H High Resolution Magic Angle Spinning NMR, PLoS ONE 11(9): e0163258.
- Thamarath Surendran S., Alia A., Bode B.E. & Matysik J. (2016), The solid-state photo-CIDNP effect, Acta Physico - Chimica Sinica 32(2): 399-404.
- Berry J.P., Roy U., Jaja-Chimedza A., Sanchez K., Matysik J. & Alia A. (2016), High-resolution magic angle spinning nuclear magnetic resonance of intact zebrafish embryos detects metabolic changes following exposure to teratogenic polymethoxyalkenes from algae, Zebrafish 13(5): 456-465.
- Najdanova M., Janssen G.J., Groot H.J.M. de, Matysik J. & Alia A. (2015), Analysis of electron donors in photosystems in oxygenic photosynthesis by photo-CIDNP MAS NMR, Journal of Photochemistry and Photobiology B: Biology 152(B): 261–271.
- Kara F., Höfling C., Roßner S., Schliebs R., Linden A. van der, Groot H.J.M. de & Alia A. (2015), In vivo longitudinal monitoring of changes in the corpus callosum integrity during disease progression in a mouse model of Alzheimer’s disease, Current Alzheimer Research 12(10): 941-950.
- Chatzopoulou Chatzi A., Upasana R., Meijer A.H., Alia A., Spaink H.P. & Schaaf M.J.M. (2015), Transcriptional and metabolic effects of glucocorticoid receptor alpha and beta signaling in zebrafish, Endocrinology 156(5): 1757-1769.
- Paul S., Bode B.E., Matysik J. & Alia A. (2015), Photochemically Induced Dynamic Nuclear Polarization Observed by Solid-State NMR in a Uniformly C-13-Isotope-Labeled Photosynthetic Reaction Center, Journal of Physical Chemistry B 119(43): 13897-13903.
- Sai Sankar Gupta K.B., Daviso E., Jeschke G., Alia A., Ernst M. & Matysik J. (2014), Spectral editing through laser-flash excitation in two-dimensional photo-CIDNP MAS NMR experiments, Journal of Magnetic Resonance 246: 9-17.
- Sirisi S., Folgueira M., López-Hernández T., Minieri L., Pérez-Rius C., Gaitán-Peñas H., Zang J., Martínez A., Capdevila-Nortes X., De La Villa P., Upasana R., Alia A., Neuhauss S., Ferroni S., Nunes V., Estévez R. & Barrallo-Gimeno A. (2014), Megalencephalic leukoencephalopathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans, Human Molecular Genetics 23(19): 5069-5086.
- Alia A., Duijn S. van, Kara F. & Buchem M.A. van (2014), Direct in vivo assessment of sex-related metabolic differences in a mouse model of Alzheimer's disease by MRI, Alzheimer's & Dementia 10(4S/22): P826.
- Amerongen Y.F van, Roy U., Spaink H.P., Groot H.J.M. de, Huster D., Schiller J. & Alia A. (2014), Zebrafish brain lipid characterization and quantification by 1H nuclear magnetic resonance spectroscopy and MALDI-TOF mass spectrometry, Zebrafish 11(3): 240-247.
- Duijn S. van, Nabuurs R.J.A., Duinen S.G. van, Natte R., Buchem M.A. van & Alia A. (2013), Longitudinal monitoring of sex-related in vivo metabolic changes in the brain of Alzheimer's disease transgenic mouse using magnetic resonance spectroscopy, Journal of Alzheimer's Disease 34(4): 1051-1059.
- Alia A., Buda F., Groot H.J.M. de & Matysik J. (2013), Solid-state NMR of nanomachines involved in photosynthetic energy conversion, Annual Review of Biophysics 42: 675-699.
- Sai Sankar Gupta K.B., Alia A., Buda F., Groot H.J.M. de & Matysik J. (2013), Bacteriopheophytin a in the active branch of the reaction center of Rhodobacter sphaeroides is not disturbed by the protein matrix as shown by C-13 photo-CIDNP MAS NMR, Journal of Physical Chemistry B 117(12): 3287-3297.
- Sai Sankar, Gupta K.B., Alia A., Groot H.J.M. de & Matysik J. (2013), Symmetry break of special pair: photochemically induced dynamic nuclear polarization NMR confirms control by nonaromatic substituents, Journal of the American Chemical Society 135(28): 10382-10387.
- Thamarath S.S., Alia A., Roy E., Sai Sankar Gupta K.B., Golbeck J.H. & Matysik J. (2013), The field-dependence of the solid-state photo-CIDNP effect in two states of heliobacterial reaction centers, Photosynthesis Research 117(1-3): 461-469.
- Kara F., Chen F., Ronen I., Groot H.J.M. de, Matysik J. & Alia A. (2013), In vivo measurement of transverse relaxation time in the mouse brain at 17.6 T, Magnetic Resonance in Medicine 70(4): 985-993.
- Ramirez I.B.R., Pietka G., Jones D.R., Divecha N., Alia A., Baraban S.C., Hurlstone A.F.L. & Lowe M. (2012), Impaired neural development in a zebrafish model for Lowe syndrome, Human Molecular Genetics 21(8): 1744-1759.
- Kara F., Dongen E.S. van, Schliebs R., Buchem M.A. van, Groot H.J.M. de & Alia A. (2012), Monitoring blood flow alterations in the Tg2576 mouse model of Alzheimer's disease by in vivo magnetic resonance angiography at 17.6 T, NeuroImage 60(2): 958-966.
- Bode B.E., Thamarath Surendran S., Sai Sankar Gupta K.B., Alia A., Jeschke G. & Matysik J. (2012), The Solid-State Photo-CIDNP Effect and Its Analytical Application. Photo-CIDNP MAS NMR to Study Radical Pairs. In: Kuhn L. (Ed.), Hyperpolarization Methods in NMR Spectroscopy. Topics in Current Chemistry no. 338. Berlin Heidelberg: Springer Verlag. 105-121.
- Thamarath S.S., Bode B.E., Prakash S., Sai Sankar Gupta K.B., Alia A., Jeschke G. & Matysik J. (2012), Electron Spin Density Distribution in the Special Pair Triplet of Rhodobacter sphaeroides R26 Revealed by Magnetic Field Dependence of the Solid-State Photo-CIDNP Effect, Journal of the American Chemical Society 134(13): 5921-5930.
- Janssen G.J., Roy E., Matysik J. & Alia A. (2012), 15N Photo-CIDNP MAS NMR To Reveal Functional Heterogeneity in Electron Donor of Different Plant Organisms, Applied Magnetic Resonance 42(1): 57-67.
- Vermeij W.P., Florea B.I., Isenia S., Alia A., Brouwer J. & Backendorf C.M.P. (2012), Proteomic Identification of in Vivo Interactors Reveals Novel Function of Skin Cornification Proteins, Journal of Proteome Research 11(6): 3068-3076.
- Thamarath Surendran S., Alia A., Daviso E., Mance D., Golbeck J.H. & Matysik J. (2012), Whole Cell Nuclear Magnetic Resonance Characterization of Two Photochemically Active States of the Photosynthetic Reaction Center in Heliobacteria, Biochemistry 51(29): 5763-5773.
- Vermeij W.P., Alia A. & Backendorf C.M.P. (2011), ROS Quenching Potential of the Epidermal Cornified Cell Envelope, Journal of Investigative Dermatology 131(7): 1435-1441.
- Alia A. & Buchem M.A. van (2011), Prospects of Magnetic Resonance Imaging for Alzheimer's Disease, Current Medical Imaging Reviews 7(1): 1-2.
- Ali S., Alia A., Champagne D.L. & Richardson M.K. (2011), Large-scale analysis of acute ethanol exposure in zebrafish development: a critical time window and resilience, PLoS ONE 6(5): e20037.
- Bagowski C.P., Bertola L.D., Schoonheere E., Wilms I., Kabli S., Alia A. & Groot H.J.M. de (2011), Effects of hypoxia on buoyancy control and the development of lordosis in physostomous and physoclistous fish species, Research & Reviews in BioSciences 5(1): 1-7.
- Kara F., Braakman N., Buchem M.A. van, Groot H.J.M. de & Alia A. (2011), Prospects of Magnetic Resonance Spectroscopy in Mouse Models of Alzheimer's Disease, Current Medical Imaging Reviews 7(1): 80-87.
- Haud N., Kara F., Diekmann S., Henneke M., Willer J.R., Hillwig M.S., Gregg R.G., MacIntosh G.C., Gartner J., Alia A. & Hurlstone A.F.L. (2011), rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA, Proceedings of the National Academy of Sciences 108(3): 1099-1103.
- Daviso E., Janssen G.J., Alia A., Jeschke G., Matysik J. & Tessari M. (2011), A 10 000-fold Nuclear Hyperpolarization of a Membrane Protein in the Liquid Phase via Solid-State Mechanism, Journal of the American Chemical Society 133(42): 16754-16757.
- Daviso E., Prakash S., Alia A., Gast P., Jeschke G. & Matysik J. (2010), Nanosecond-Flash N-15 Photo-CIDNP MAS NMR on reaction centers of Rhodobacter sphaeroides R26, Applied Magnetic Resonance 37: 49-63.
- Kara F. & Alia A. (2010), Magnetic resonance angiography of the mouse cerebrovascular system at 17.6 T. . Proc.Intl.Soc.Mag.Reson.Med.
- Kara F., Braakman N., Buchem M.A. van, Groot H.J.M. de, Schliebs R. & Alia A. (2010), In vivo longitudinal monitoring of blood flow alterations in TG2576 mouse model of Alzheimer's Disease, 2010 ISMRM Meeting proceedings. Joint Annual Meeting of the ISMRM 1 May 2010 - 7 May 2010. Proc.Intl.Soc.Mag.Reson.Med. 4273.
- Duijn S. van, Kara F., Braakman N., Duinen S.G. van, Natte R., Buchem M.A. van & Alia A. (2010), 2D L-Cosy MR spectroscopy detects very early changes in the brain of Alzheimer mouse. Joint Annual Meeting of the ISMRM 1 May 2010 - 7 May 2010. Proc.Intl.Soc.Mag.Reson.Med.. Concord, U.S.A.: ISMRM. 4257.
- Janssen G.J., Daviso E., Van Son M., Groot H.J.M. de, Alia A. & Matysik J. (2010), Observation of the solid-state photo-CIDNP effect in entire cells of cyanobacteria Synechocystis, Photosynthesis Research 104(2-3): 275-282.
- Daviso E., Diller A., Gast P., Alia A., Lugtenburg J., Müller M.G. & Matysik J. (2010), Action spectroscopy on dense samples of photosynthetic reaction centers of Rhodobacter sphaeroides WT based on nanosecond laser-flash C-13 Photo-CIDNP MAS NMR, Applied Magnetic Resonance 38: 105-116.
- Kabli S., He S.N., Spaink H.P., Hurlstone A., Snaar-Jagalska B.E., Groot H.J.M. de & Alia A. (2010), In vivo magnetic resonance imaging to detect malignant melanoma in adult zebrafish, Zebrafish 7(2): 143-148.
- Daviso E., Prakash S., Alia A., Gast P., Neugebauer J., Jeschke G. & Matysik J. (2009), The electronic structure of the primary electron donor of reaction centers of purple bacteria at atomic resolution as observed by photo-CIDNP C-13 NMR, Proceedings of the National Academy of Sciences 106(52): 22281-22286.
- Braakman N., Kara F., Buchem M.A. van, Schliebs R., Groot H.J.M. de & Alia A. (2009), In vivo localized two dimensional MR spectroscopy to compare the neurochemical profile in wild-type and transgenic mouse of Alzheimer’s disease, Proceedings of the 17th Annual ISMRM Scientific Meeting and Exhibition 2009. 17th Annual ISMRM Scientific Meeting and Exhibition 2009 18 April 2009 - 24 April 2009. Berkeley, California: International Society for Magnetic Resonance in Medicine. 1671-1671.
- Braakman N., Buchem M.A. van, Schliebs R., Groot H.J.M. de & Alia A. (2009), Recent Advances in Visualizing Alzheimer's Plaques by Magnetic Resonance Imaging, Current Medical Imaging Reviews 5(1): 2-9.
- Daviso E., Alia A., Prakash S., Diller A., Gast P., Lugtenburg J., Matysik J. & Jeschke G. (2009), Electron-nuclear spin dynamics in a bacterial photosynthetic reaction center, The Journal of Physical Chemistry Part C 113(23): 10269-10278.
- Alia A., Ganapathy S. & Groot H.J.M. de (2009), Magic Angle Spinning (MAS) NMR: a new tool to study the spatial and electronic structure of photosynthetic complexes, Photosynthesis Research 102(2): 415-425.
- Kabli S., Spaink H.P., Groot H.J.M. de & Alia A. (2009), In Vivo metabolite profile of adult zebrafish brain obtained by high-resolution localized magnetic resonance spectroscopy, Journal of Magnetic Resonance Imaging 29(2): 275-281.
- Muskulus M., Scheenstra A.E.H., Braakman N., Dijkstra J., Verduyn Lunel S.M., Alia A., Groot H.J.M. de & Reiber J.H. (2009), Prospects for early detection of Alzheimer's disease from serial MR images in transgenic mouse models, Current Alzheimer Research 6(6): 503-518.
- Alia A., Wawrzyniak P.K., Janssen G.J., Buda F., Matysik J. & Groot H.J.M. de (2009), Differential charge polarization of axial histidines in bacterial reaction centers balances the asymmetry of the special pair, Journal of the American Chemical Society 131(28): 9626-9627.
- Braakman N., Oerther T., Groot H.J.M. de & Alia A. (2008), High resolution localized two-dimensional MR spectroscopy in mouse brain in vivo, Magnetic Resonance in Medicine 60(2): 449-456.
- Wawrzyniak P.K., Alia A., Schaap R.G., Heemskerk M.M., Groot H.J.M. de & Buda F. (2008), Protein-induced geometric constraints and charge transfer in bacteriochlorophyll-histidine complexes in LH2, Physical Chemistry Chemical Physics 10(46): 6971-6978.
- Roy E., Rohmer T., Gast P., Jeschke G., Alia A. & Matysik J. (2008), Characterization of the primary radical pair in reaction centers of heliobacillus mobilis by 13C Photo-CIDNP MAS NMR, Biochemistry 47(16): 4629-4635.
- Diller A., Alia A., Gast P., Groot H.J.M. de, Glaubitz C., Jeschke G. & Matysik J. (2008), 13C Photo-CIDNP MAS NMR studies on oriented reaction centers. In: Allen J.F., Gantt E., Golbeck J.H. & Osmond B. (Eds.), Photosynthesis. energy of sun: 14th international congress on photosynthesis research 2007. Dordrecht: Springer. 97-100.
- Diller A., Prakash S., Alia A., Gast P., Matysik J. & Jeschke G. (2007), Signals in solid-state photochemically induced dynamic nuclear polarization recover faster than signals obtained with the longitudinal relaxation time, Journal of Physical Chemistry B 111(35): 10606-10614.
- Diller A., Roy E., Gast P., Gorkom H.J. van, Groot H.J.M. de, Glaubitz C., Jeschke G., Matysik J. & Alia A. (2007), 15N-photochemically induced dynamic nuclear polarization magic-angle spinning NMR analysis of the electron donor of photosystem II, Proceedings of the National Academy of Sciences 104(31): 12767-12771.
- Roy E., Alia A., Gast P., Gorkom H.J. van, Groot H.J.M. de, Jeschke G. & Matysik J. (2007), Photochemically induced dynamic nuclear polarization observed in the reaction center of the green sulphur bacteria Chlorobium tepidum by 13C MAS NMR, Biochimica et Biophysica Acta (BBA) - Bioenergetics 1767(6): 610-615.
- Prakash S., Alia A., Gast P., Groot H.J.M. de, Jeschke G. & Matysik J. (2007), 13C chemical shift map of the active cofactors in photosynthetic reaction centers of Rhodobacter sphaeroides revealed by photo-CIDNP MAS NMR, Biochemistry 46(31): 8953-8960.
- Roy E., Alia A., Gast P., Groot H.J.M. de, Jeschke G., Gorkom H.J. van & Matysik J. (2007), Photochemically induced dynamic nuclear polarization studies on photosynthetic reaction centers from diverse organisms, Photosynthesis Research 91: 151-151.
- Alia A., Wawrzyniak P.K., Buda F., Matysik J. & Groot H.J.M. de (2007), Electronic structure of axial histidines in photosynthetic reaction centres of Rhodobacter sphaeroides, Photosynthesis Research 91(2-3): 146-147.
- Diller A., Alia A., Roy E., Gast P., Groot H.J.M. de, Gorkom H.J. van, Jeschke G., Glaubitz C. & Matysik J. (2007), The origin of the high redox force of photosystem II, a photo-CIDNP MAS NMR analysis, Photosynthesis Research 91(2-3): 150.
- Daviso E., Sai Sankar Gupta K.B., Prakash S., Gast P., Alia A., Jeschke G. & Matysik J. (2007), 15N photo-CIDNP MAS NMR on RCs of Rhodobacter sphaeroides WT and R26. Allen J.F., Gantt E., Golbeck J.H. & Osmond B. (Eds.), Photosynthesis. Energy from the Sun: 14th International Congress on Photosynthesis Research 2007. 14th International Congress on Photosynthesis 1 July 2007 - 4 July 2007. Dordrecht: Springer. 21-24.
- Diller A., Alia A., Gast P., Jeschke G. & Matysik J. (2007), 13C Photo-CIDNP MAS NMR on the LH1-RC complex of Rhodopseudomonas acidophila. Allen J.F. (Ed.), Photosynthesis. Energy from the Sun. . 14th International Congress on Photosynthesis 1 July 2007 - 4 July 2007. Dordrecht: Springer. 54-54.
- Roy E., Diller A., Alia A., Gast P., Gorkom H.J. van, Groot H.J.M. de, Jeschke G. & Matysik J. (2006), Magnetic field dependence of 13C photo-CIDNP MAS NMR in plant photosystems I and II, Applied Magnetic Resonance 31: 193.
- Braakman N., Matysik J., Duinen S.G. van, Verbeek F.J., Schlebs R., Groot H.J.M. de & Alia A. (2006), Longitudinal assessment of Alzheimer's beta-amyloid plaquedevelopment in transgenic mice monitored by in vivo magnetic resonance microimaging, Journal of Magnetic Resonance Imaging 24(3): 530-536.
- Prakash S., Alia A., Gast P., Groot H.J.M. de, Matysik J. & Jeschke G. (2006), Photo-CIDNP MAS NMR in intact cells of Rhodobacter sphaeroides R26: molecular and atomic resolution at nanomolar concentration?, Journal of the American Chemical Society 128(39): 12794-12799.
- Kabli S., Alia A., Spaink H.P., Verbeek F.J. & Groot H.J.M. de (2006), Magnetic resonance microscopy of the adult zebrafish, Zebrafish 3(4): 431-439.
- Prakash S., Alia A., Gast P., Groot H.J.M. de, Jeschke G. & Matysik J. (2005), Magnetic field dependence of photo-CIDNP MAS NMR on photosynthetic reaction centers of Rhodobacter sphaeroides WT, Journal of the American Chemical Society 127(41): 14290-14298.
- Diller A., Alia A., Roy E., Gorkom H.J. van, Zaanen J., Groot H.J.M. de, Glaubitz C., Matysik J. & Gast P. (2005), Photo-CIDNP solid-state NMR on photosystems I and II: what makes P680 special?, Photosynthesis Research 84(1-3): 303-308.
- Alia A., Roy E., Gast P., Gorkom H.J. van, Groot H.J.M. de, Jeschke G. & Matysik J. (2004), Photochemically induced dynamic nuclear polarization in Photosystem I of plants observed by 13C magic-angle spinning NMR, Journal of the American Chemical Society 126(40): 12819-12826.
- Alia A., Matysik J., Boer I. de, Gast P., Gorkom H.J. van & Groot H.J.M. de (2004), Heteronuclear 2D (1H-13C) MAS NMR resolves the electronic structure of coordinated histidines in light-harvesting complex II: assessment of charge transfer and electronic delocatlization effect, Journal of Biomolecular NMR 28(2): 157-164.
- Alia A., Hulsebosch B., Gorkom H.J. van, Raap J., Lugtenburg J., Matysik J., Groot H.J.M. de & Gast P. (2003), Probing the electronic structure of tyrosine radial Y-D (center dot) in photosystem II by EPR spectroscopy using site specific isotope labelling in Spirodela oligorrhiza, Chemical Physics 294(3): 459-469.
- Prakash S., Alia A., Gast P., Jeschke G., Groot H.J.M. de & Matysik J. (2003), Photochemically induced dynamic nuclear polarisation in entire bacterial photosynthetic units observed by C-13 magic-angle spinning NMR, Journal of Molecular Structure 661-662: 625-633.
- Matysik J., Alia A., Bhalu B. & Mohanty P. (2002), Molecular Mechanisms of Quenching of Reactive Oxygen Species by Proline Under Stress in Plants, Current Science 82(5): 525-532.
- Schulten E.A.M., Matysik J., Alia A., Kiihne S.R., Raap J., Lugtenburg J., Gast P., Hoff A.J. & Groot H.J.M. de (2002), 13C MAS NMR and photo-CIDNP reveal a pronounced assymetry in the electron ground state of the special pair of Rhodobacter spearoides reaction centers, Biochemistry 41(27): 8708-8717.
- Alia A., Matysik J., Soede-Huijbregts C., Baldus M., Raap J., Lugtenburg J., Gast P., Gorkom H.J. van, Hoff A.J. & Groot H.J.M. de (2001), Ultrahigh field MAS NMR dipolar correlation spectroscopy of the histidine residues in light-harvesting complex II from photosynthetic bacteria levels partial internal charge transfer in the B850/his complex, Journal of the American Chemical Society 123(20): 4803-4809.
- Matysik J., Alia A., Gast P., Lugtenburg J., Hoff A.J. & Groot H.J.M. de (2001), Photochemically Induced Dynamic Nuclear Polarization in Bacterial Photosynthetic Reaction Centers Observed by 13C Solid State NMR. In: Kiihne S.R. & Groot H.J.M. de (Eds.), Perspectives on Solid State NMR in Biology. Focus on Structural Biology no. 1. Dordrecht, The Netherlands: Springer. 215-225.
- Matysik J. & Alia A. (2001), The Photophysics and Photochemistry of Cytochrome-C Oxidase. In: Pardha Saradhi P. (Ed.), Biophysical Processes in Living Systems. Enfield: Science Publishers Inc..
- Alia A., Mohanty P. & Matysik J. (2001), Effect of Proline on the Production of Singlet Oxygen, Amino Acids 21(2): 195-200.
- Matysik J., Schulten E., Alia A., Gast P., Raap J., Lugtenburg J., Hoff A.J. & Groot H.J.M. de (2001), Photo-CIDNP 13C magic angle spinning NMR on bacterial reaction centres: exploring the electronic structure of the special pair and its surroundings, Biological Chemistry 382(8): 1271-1276.
- Matysik J., Alia A., Gast P., Gorkom H.J. van, Groot H.J.M. de & Hoff A.J. (2000), Photochemically induced nuclear spin polarization in reaction centers of photosystem II observed by 13C-solid-state NMR reveals a strongly asymmetric electronic structure of the P680.+ primary donor chlorophyll, Proceedings of the National Academy of Sciences 97(18): 9865-9870.
- Alia A., Matysik J., Erkelens C., Hulsbergen F.B., Gast P., Lugtenburg J. & Groot H.J.M. de (2000), Bacteriochlorophyll/imidazole and chlorophyll/imidazole complexes are negatively charged in an apolar environment, Chemical Physics Letters 330(3-4): 325-330.
- Matysik J., Alia A., Hollander J.G., Egorova T., Gast P. & Groot H.J.M. de (2000), A set-up to study photochemically induced dynamic nuclear polarization in photosynthetic reaction centres by solid-state NMR, Indian Journal of Biochemistry and Biophysics 37(5): 418-423.
- Alia A., Matysik J., Soede-Huijbregts C., Gast P., Raap J., Lugtenburg J., Groot H.J.M. de & Gorkom H.J. van (1998), Selective 15N-isotope labelling of histidines in PSII reaction centers of Spirodela oligorrhiza. In: Garab G. (Ed.), Photosynthesis: Mechanisms and Effects no. II. Dordrecht, The Netherlands: Kluwer Academic Publishers. 1009-1012.
- Matysik J., Alia A., Gorkom H.J. van & Groot H.J.M. de (1998), Substitution of calcium by cadmium in Photosystem II complex. In: Garab G. (Ed.), Photosynthesis: Mechanisms and Effects, Vol. II. Dordrecht, The Netherlands: Kluwer Academic Publishers. 1423-1426.
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