Predictive Pharmacology

Key publications

Key publications of the Predictive Pharmacology group.

Qin T, Prins S, Groeneveld GJ, Van Westen G, de Vries HE, Wong YC, Bischoff LJM, de Lange ECM. Utility of Animal Models to Understand Human Alzheimer's Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals. Int J Mol Sci. 2020 Apr 30;21(9). pii: E3158. doi: 10.3390/ijms21093158
Brink W.J. van den, Hartman R., Berg D.J. van den, Flik G., Gonzalez-Amoros B, Koopman N., Elassais-Schaap J., Graaf P.H. van der, Hankemeier T. & Lange E.C.M. de (2019), Blood- Based Biomarkers of Quinpirole Pharmacology: Cluster- Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain, CPT: Pharmacometrics & Systems Pharmacology 8(2): 107-117.
Witte W.E.A. de, Danhof M., Graaf P.H. van der & Lange E.C.M. de (2019), The implications of target saturation for the use of drug-target residence time, Nature Reviews Drug Discovery 18(1): 82-84.
Wong Y.C., Centanni M. & Lange E.C.M. de (2019), Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human, The Journal of Clinical Pharmacology 59(5): 731-747.
Yamamoto Y., Välitalo P.A., Wong Y.C., Huntjens D.R., Proost J.H., Vermeulen A., Krauwinkel W., Beukers M.W., Kokki H., Kokki M., Danhof M., van Hasselt J.G.C., de Lange E.C.M., Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach. Eur J Pharm Sci. 2018; 112: 168-179.
Vlot A.H.C., Witte W.E.A., Danhof M., van der Graaf P.H., van Westen G.J.P., de Lange E.C.M., Target and tissue selectivity prediction by integrated mechanistic pharmacokinetic-target binding and quantitative structure activity modelling AAPSJ. 2017; 20(1): 11.
De Lange E.C.M., van der Brink W., Yamamoto Y., de Witte W., Wong Y.C., Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics. Expert Opin Drug Discov. 2017;12(12): 1207-1218.
van den Brink W.J., Elassais-Schaap J., Gonzalez B., Harms A., van der Graaf P.H., Hankemeier T., de Lange E.C.M., Remoxipride causes multiple pharmacokinetic/pharmacodynamic response patterns in pharmacometabolomics in rats. Eur J Pharm Sci. 2017;109: 431-440.
De Witte W., Danhof M., van der Graaf P.H., de Lange E.C., In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant. Trends Pharmacol Sci. 2016; 37(10): 831-42.
Stevens J., Ploeger B., Hammarlund-Udenaes M., Osswald G., van der Graaf P.H., Danhof M., de Lange E.C.M., Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans. J Pharmacokinet Pharmacodyn 2012 39(5): 463-77.