Brünle Lab / Structural Biology of GPCRs

Steffen Brünle's group investigates G protein-coupled receptors (GPCRs). These essential membrane proteins are prime targets for therapeutic drug development in disease and cancer treatment.

The approach combines structural analysis via single-particle cryo-electron microscopy as well as classical and serial X-ray crystallography with functional study's to uncover the molecular basis of receptor activation and regulation. The group is part of the Leiden Early Drug Discovery & Development (LED3) network, providing structural biology expertise to support the hit and lead optimization pipeline.