In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
- Gilles van Wezel
In Microbial Sciences, we perform multidisciplinary research to understand the structure and function of microbes at all levels of biological organization, from small molecules and cellular structures at atomic resolution to multicellular communities.
We investigate how microbes sense and respond to their environment and interact with other organisms, and harness Nature's Biodiversity to discover novel bioactive molecules and enzymes, which find application in the clinical trajectory and in biotechnology.
Microbial Sciences contributes to the IBL research themes in the following ways:
Discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.
Unravel the processes that control cellular morphogenesis, growth, development and virulence, and visualise cellular structures and components from cellular level to atomic detail.
Understand how diversity and evolution are influenced by cooperative and antagonistic interactions taking place between microbes.
Dissect how microorganisms and microbial communities interact with eukaryotic hosts and how these insights may be harnessed to improve the health of the host.
Connection with other research
- Efficient targeting of the Trichoderma genome for industrial protein engineering
- Heterogeneity in spores of food spoilage fungi
- Plant-microbe interactions
- Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
- Cell architecture and pathways for parallel secretion in the filamentous fungus Aspergillus niger
- Improving the filamentous fungus Aspergillus niger as cell factory for starch degrading enzymes
- Regulation of enzyme production in fungal cell factories
- Cell Wall Dynamics in Aspergillus niger
- Functions of autophagy in the filamentous fungus Aspergillus niger
- Quest for new antibiotics
- Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
- Microbial Chemotaxis
- Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
- Anticancer compounds from actinomycetes
- Cryo-EM of cholera infection
- Fungal Chitosans from Fermentation Mycelia for Plant Biostimulants (FunChi)
- Regulatory networks in Streptomyces
- Harnessing the soil microbiome for improved stress tolerance in crop plants