Universiteit Leiden

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Research project

Development of novel metabolomics and systems pharmacology methods

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Thomas Hankemeier

We have developed a unique series of untargeted platforms (to cover the physicochemical and biochemical space of metabolites) and targeted biology-driven platforms (to cover specific metabolites present at ultra-low concentrations and/or requiring specialised sample pre-treatment). Our current metabolomics methods can detect >2000 metabolites and lipids; half of these compounds are identified, and 25% are reported in absolute concentrations. For example, we are interested to better study modified fatty acids and lipids.


We are miniaturizing our platforms using nanoLC-MS and improving the injection into CE-MS and the interfacing of CE and MS.

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