Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in in-vitro (organ-on-a-chip) and animal models. For example, we try to understand why 30% of diabetic patients develop kidney disease, and why not all patients benefit from pharmacological treatment to prevent kidney disease. This can help to predict the proper treatment of patients (who needs what treatment), and to develop novel pharmacological interventions taking interindividual differences patients into account. Next to (cardio)vascular diseases we apply this approach also to neurodegenerative diseases.