Universiteit Leiden

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Research project

Conquering the fortress: New strategies for the treatment of tuberculosis

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

Duration
2019  -   2023
Contact
Monica Varela Alvarez
Funding
NWO - Veni NWO - Veni

Description

Drug-resistant tuberculosis is the most lethal airborne disease worldwide. The causative bacteria hide in compact conglomerates of cells (granulomas) that limit the effectiveness of antibiotics and host immune responses. The aim of this project is developing new host-directed therapies able to attack this ‘tuberculosis fortress’ and increase the effectiveness of current anti-tuberculosis therapies or novel phage-based therapies.

Publications

https://openaccess.leidenuniv.nl/handle/1887/77334 

Mycobacteria (green) hide in compact cell aggregates (granulomas). Credits: Monica Varela
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