Dissertation
Synthesis of ADP-ribose Analogues
Since the global COVID-19 pandemic, the coronavirus responsible (SARS-CoV-2) has been extensively probed for promising protein targets to establish drug-based therapies.
- Author
- K.J. Rijpkema
- Date
- 16 April 2026
- Links
- Thesis in Leiden Repository
One of these protein targets, the macrodomain known as Mac1, binds the post-translational modification adenosine-diphosphate-ribose (ADP-ribose) and removes it from important immunological signalling molecules. This process, critical for the propagation of the virus, can be inhibited by introducing a molecule that binds better to Mac1 than the ADP-ribose, namely, an ADP-ribose analogue.
In his thesis titled ADP-ribose analogues the author Koen J. Rijpkema explores the different facets of the ADP-ribose molecule and the way that structurally changing these facets through synthetic organic chemistry has an influence on the binding affinity of the analogues for Mac1.