Universiteit Leiden

nl en

Dissertation

Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Author
Witte, W.E.A. de
Date
19 December 2017
Links
Thesis in Leiden Repository

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction. However, the time course of a drug effect is also influenced by many other physiological processes such as the metabolism and excretion of a drug and the transduction of the relevant biological signals. In this study, we investigate when target binding kinetics are determining the time course of drug effect and generate understanding into the relation between the parameter values and the rate-limiting step in the duration of a drug effect.