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Dissertation

Activity-based proteomics of the endocannabinoid system

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Author
Rooden, E.J. van
Date
11 September 2018
Links
Thesis in Leiden Repository

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system. A protocol for label-free chemical proteomics to measure serine hydrolase activity in mouse tissue is described. This method is used to compare a Niemann-Pick Type C mouse model to healthy mice. Additionally, several novel activity-based probes for the enzymes diacylglycerol lipase alpha and a/b-hydrolase domain containing protein 6 are described.

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