LED3 Lecture: Chemical Probes for imaging and analysis of hydrolase function in Cancer, Infectious Diseases and the microbiome
- Friday 18 March 2022
2333 CC Leiden
- Havinga Lecture room
The new LED3 chemical biology lecture series will kick off on March 18th with a lecture by Prof. Matthew Bogyo (Stanford Medicine).
Hydrolases are enzymes (i.e. proteases, esterases, lipases) that often play pathogenic roles in many common human diseases such as cancer, asthma, arthritis, atherosclerosis and infection by pathogens. Therefore, tools that allow dynamic monitoring of their activity can be used as research tools, as diagnostic agents, as imaging contrast agents and for the identification of novel enzymes as drug leads.
In this presentation, I will describe our efforts using small molecule probes to identify, inhibit and image various hydrolase targets in models of cancer and infectious disease as well as in the human gut microbiome. This will include recent advances in protease activated fluorescent probes for real-time visualization of tumors during surgery as well our efforts to identify several new classes of hydrolases in commensal bacteria. We believe many of these enzymes will represent valuable imaging and therapy targets that can be used to visualize and disrupt various aspects of colonization and community formation inside a host.