Xinyu Di
Guest researcher
- Name
- Dr. X. Di
- Telephone
- 071 5272727
- x.di@lic.leidenuniv.nl
Guest researcher
- Faculty of Science
- LIC
- Chemistry for Human Health
- Molecular Physiology
Contact
- Huang X., Di X., Zuiderwijk M.C., Zhang L., Leegwater H., Davidse S., Kindt A., Harms A.C., Hankemeier T., Le Dévédec S.E. & Ali A. (2025), Lipidomic profiling of triple-negative breast cancer cells reveals distinct metabolic signatures associated with EpCAM expression, Talanta 283: 127127.
- Eenige R. van, Sánchez-López E., Hoekstra A.T., Ying Z., Boon M.R., Mock E.D., Di X., Giera M., Stelt M. van der, Rensen P.C.N. & Kooijman S. (2025), Inhibition of endocannabinoid synthesis enzymes DAGL and NAPE-PLD transiently lowers body weight and alters glucose homeostasis during a high-fat diet challenge in mice, European Journal of Endocrinology 193(5): 518-526.
- Di X., Martinez-Tellez B., Krekels E.H.J., Jurado-Fasoli L., Osuna-Prieto F.J., Ortiz-Alvarez L., Hankemeier T., Rensen P.C.N., Ruiz J.R. & Kohler I. (2024), Higher plasma levels of endocannabinoids and analogues correlate with a worse cardiometabolic profile in young adults, The Journal of Clinical Endocrinology and Metabolism 109(5): 1351-1360.
- Yang W., Schoeman J.C., Di X., Lamont L., Harms A.C. & Hankemeier T. (2024), A comprehensive UHPLC-MS/MS method for metabolomics profiling of signaling lipids: markers of oxidative stress, immunity and inflammation, Analytica Chimica Acta 1297: 342348.
- Jurado-Fasoli L., Sanchez-Delgado G., Di X., Yang W., Kohler I., Villarroya F., Aguilera C.M., Hankemeier T., Ruiz J.R. & Martinez-Tellez B. (2024), Cold-induced changes in plasma signaling lipids are associated with a healthier cardiometabolic profile independently of brown adipose tissue, Cell Reports Medicine 5(2): 101387.
- Jiang M., Huizenga M.C.W., Wirth J.L., Paloczi J., Amedi A., Berg R.J.B.H.N. van den, Benz J., Collin L., Deng H., Di X., Driver W.F., Florea B.I., Grether U., Janssen A.P.A., Hankemeier T., Heitman L.H., Lam T.W., Mohr F., Pavlovic A., Ruf I., Hurk H. van den, Stevens A.F., Vliet D. van der, Wel T. van der, Wittwer M.B., Boeckel C.A.A. van, Pacher P., Hohmann A.G. & Stelt M. van der (2023), A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence, Nature Communications 14(1): 8039.
- Jiang M., Huizenga M.C.W., Wirt J.L., Paloczi J., Amedi A., Berg R.J.B.H.N. van den, Benz J., Collin L., Deng H., Di X., Driever W.P.F., Florea B.I., Grether U., Janssen A.P.A., Hankemeier T., Heitman L.H., Lam T.-W., Mohr F.D., Pavlovic A., Ruf I., Hurk H. van den, Stevens A.F., Vliet D. van der, Wel T. van der, Wittwer M.B. Boeckel C.A.A. van, Pacher P., Hohmann A.G. & Stelt M. van der (2023), A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence, Nature Communications 14(1): 8039.
- Di X. (7 February 2023), Exploration of the endocannabinoid system using metabolomics (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Supervisor(s) and Co-supervisor(s): Hankemeier T., Kohler I. & Krekels E.H.J.
- Jurado-Fasoli L., Di X., Sanchez-Delgado G., Yang W., Osuna-Prieto F.J., Ortiz-Alvarez L., Krekels E., Harms A.C., Hankemeier T., Schonke C., Aguilera C.M., Llamas-Elvira J.M., Kohler I., Rensen P.C.N., Ruiz J.R. & Martinez-Tellez B. (2022), Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial, EBioMedicine 85: 104313.
- Jurado-Fasoli L., Di X.Y., Kohler I., Osuna-Prieto F.J., Hankemeier T., Krekels E.H.J., Harms A.C., Yang W., Garcia-Lario J.V., Fernandez-Veledo S., Ruiz J.R., Rensen P.C.N. & Martinez-Tellez B. (2022), Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults, Obesity 30(1): 50-61.
- Ortiz-Alvarez L., Xu H., Di X., Kohler I., Osuna-Prieto F.J., Acosta F.M., Vilchez-Vargas R., Link A., Plaza-Díaz J., Stelt M. van der, Hankemeier T., Clemente-Postigo M., Tinahones F.J., Gil A., Rensen P.C.N., Ruiz J.R. & Martinez-Tellez B. (2022), Plasma levels of endocannabinoids and their analogues are related to specific fecal bacterial genera in young adults: role in gut barrier integrity, Nutrients 14(10): 2143.
- He B.S., Di X., Gulded F., Harder A.V.E., Maagdenberg A.M.J.M. van den, Terwindt G.M., Krekels E.H.J., Kohler I., Harms A.C., Ramautar R. & Hankemeier T. (2022), Quantification of endocannabinoids in human cerebrospinal fluid using a novel micro-flow liquid chromatography-mass spectrometry method, Analytica Chimica Acta 1210: 339888.
- Osuna-Prieto F.J., Martinez-Tellez B., Ortiz-Alvarez L., Di X.Y., Jurado-Fasoli L., Xu H.W., Ceperuelo-Mallafre V., Nunez-Roa C., Kohler I., Segura-Carretero A., Garcia-Lario J.W., Gil A., Aguilera C.M., Llamas-Elvira J.M., Rensen P.C.N., Vendrell J., Ruiz J.R. & Fernández-Veledo S. (2021), Elevated plasma succinate levels are linked to higher cardiovascular disease risk factors in young adults, Cardiovascular Diabetology 20(1): 151.
- Mock E.D., Mustafa M., Gunduz-Cinar O., Cinar R., Petrie G.N., Kantae V., Di X., Ogasawara D., Varga Z.V., Paloczi J., Miliano C., Donvito G., Esbroeck A.C.M. van, Gracht A.M.F. van der, Kotsogianni I., Park J.K., Martella A., Wel T. van der, Soethoudt M., Jiang M., Wendel T.J., Janssen A.P.A., Bakker A.T., Donovan C.M., Castillo L.I., Florea B.I., Wat J., Hurk H. van den, Wittwer M., Grether U., Holmes A., Boeckel C.A.A. van, Hankemeier T., Cravatt B.F., Buczynski M.W., Hill M.N., Pacher P., Lichtman A.H. & Stelt M. van der (2020), Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice, Nature Chemical Biology 16(6): 667-675.
- Zhou J., Mock E.D., Al Ayed K., Di X., Kantae V., Burggraaff L., Stevens A.F., Martella A., Mohr F., Jiang M., Wel T. van der, Wendel T.J., Ofman T.P., Tran Y., Koster N. de, Westen G.J.P. van, Hankemeier T. & Stelt M. van der (2020), Structure-Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family, Journal of Medicinal Chemistry 63(17): 9340-9359.
- Esbroeck A.C.M. van, Varga Z.V., Di X., Rooden E.J. van, Tóth V.E., Onódi Z., Kuśmierczyk M., Leszek P., Ferdinandy P., Hankemeier T., Stelt M. van der & Pacher P. (2019), Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system, Pharmacological Research 151: 104578.
- Esbroeck A.C.M. van, Kantae V., Di X., Wel T. van der, Dulk J. den, Stevens A.F., Singh S., Bakker A.T., Florea B.I., Stella N., Overkleeft H.S., Hankemeier T. & Stelt M. van der (2019), Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells, Frontiers in Molecular Neuroscience 12: 286.
- Esbroeck A.C.M. van, Kantae V., Di X., Wel T. van der, Dulk J. den, Stevens A.F., Singh S., Bakker A.T., Florea B.I., Stella N., Overkleeft H.S., Hankemeier T. & Stelt M. van der (2019), Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells, Frontiers in Molecular Neuroscience 12: 286.