Postdoc / guest
Suruchi Bakshi (Dr.) is a postdoctoral at the Division of Systems Biomedicine and Pharmacology.
Suruchi Bakshi has a dual background in Biology and Mathematics. She completed her Bachelors and Masters in Biological sciences from India. She then pursued a PhD in Mathematical modelling of biological systems at the University of Oxford. During her PhD she learned the art of translating a biological system into a mathematical model and then applying the techniques of dynamical systems analysis to understand the behavior of such models.
As a postdoctoral researcher at Leiden Suruchi is trying to apply mathematical analysis technique to pharmacological models. Currently she is working on a systems pharmacology model of the alternate pathway of complement activation. She aims to analyse this model using mathematical techniques, data fitting and hypothesis testing in collaboration with experimental biologists. The goal of this analysis is to understand the positive feedback in the system and assess the key processes which determine the outcome. This is expected to suggest druggable targets in the pathway.
She has also worked on a nonlinear pharmacodynamic model of Prolactin response to D2 receptor antagonists. Suruchi analysed the model using phase-planes and bifurcation analysis to show that the model has two steady states and identified conditions of stability for either of the steady states.
Suruchi is also in charge of data management for Top Institute Pharma – PKPD Platform 2.0. She handles data uploading, secure storage and anonymization, along with storage and sharing of resulting PKPD models with appropriate partners.
No relevant ancillary activities