Sophie Wintermans
Postdoc
- Name
- Ir. S.E.L. Wintermans
- Telephone
- 071 5272727
- s.e.l.wintermans@lic.leidenuniv.nl

Sophie Wintermans obtained her BSc and MSc in Molecular Life Sciences from Wageningen University & Research (Wageningen, the Netherlands). There, she specialized in both organic chemistry and biochemistry, with a focus on early drug development. During an internship with Symeres (Nijmegen, the Netherlands), she synthesized cyclin dependent kinase inhibitors for developing new anti-cancer drugs. During her MSc thesis with Dr. Bauke Albada, she worked with DNA catalysts called nucleoapzymes to selectively modify tyrosine residues in an enzyme-like fashion, which can be used as a tool for e.g., bioconjugation of drugs to antibodies. She then joined the Medical Biochemistry lab (Leiden University, the Netherlands) as a PhD candidate under the supervision of Dr. Marta Artola and Dr. René Olsthoorn to develop new small-molecule drugs targeting RNA pseudoknots. For this, she developed a novel high throughput assay to screen for potential RNA-binding molecules, which can now be applied to different RNA structures in hopes of finding new antimicrobial compounds.
Postdoc
- Faculty of Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
- Wintermans S.E.L., Hoffmann J.S., Kuijk V. van, Durmus Y., Tacoma M.D., Broekhuizen I., Janssen A.P.A., Elst H. van den, Doodewaerd B.R. van, Geurink P.P., Artola M. & Olsthoorn R.C.L. (2025), High-throughput competitive binding assay for targeting RNA tertiary structures with small molecules: application to pseudoknots and G-quadruplexes, Nucleic Acids Research 53(16): gkaf819.
- Wintermans S.E.L., Keijzer J.F., Dros M., Zuilhof H. & Albada B. (2021), Aptamer-assisted bioconjugation of tyrosine derivatives with hemin/G-quadruplex (hGQ) DNAzyme nucleoapzyme nanostructures, ChemCatChem 13(21): 4618-4624.