Olivier Béquignon
Assistant professor
- Name
- Dr. O.J.M. Béquignon
- Telephone
- 071 5272727
- o.j.m.bequignon@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-7554-9220
Olivier is a fourth year PhD student under the lead of Pr. dr. Bob van de Water and Pr. dr. Gerard J. P. van Westen. His research focuses on cheminformatics and on the improvement of translational efficacy and safety assessment of compounds by integrating both in vitro High Content Imaging derived data and multispecies proteochemometrics modelling. This project, part of the eTRANSAFE European project (etransafe.eu), focuses the reliability of predictions of machine learning models from the perspective of translational toxicity and efficacy of new drugs.
More information about Olivier Béquignon
Assistant professor
- Faculty of Science
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal chemistry
- Béquignon O.J.M. (11 June 2025), Lost in chemical space, found in data: machines learning from patterns in medicinal chemistry and toxicology (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Supervisor(s): Westen G.J.P. van & Water B. van de.
- Maagdenberg H.W. van den, Šícho Martin A.D.A., Luukkonen S., Schoenmaker L., Jespers M., Béquignon O.J.M., Gorostiola González M.G., Broek R.L. van den, Bernatavicius R., Hasselt J.G.C. van, Graaf P.H. van der & Westen G.J.P. van (2024), QSPRpred: a flexible open-source quantitative structure-property relationship modelling tool, Journal of Cheminformatics 16: 128.
- den Hollander Lisa S. Zweemer Annelien J.M. Béquignon Olivier J.M. Hammerl Dora M. Bleijs Bente T.M. Veenhuizen Margo Lantsheer Wernard J.F. Chau Bobby van Westen Gerard J.P. IJzerman Adriaan P. Heitman Laura H. (2024), CC chemokine receptor 2 is allosterically modulated by sodium ions and amiloride derivatives through a distinct sodium ion binding site, Biochemical Pharmacology 229: 116464.
- Béquignon O.J.M., Gómez-Tamayo J.C., Lenselink E.B., Wink S., Hiemstra S.W., Lam C.C., Gadaleta D., Roncaglioni A., Norinder U., Water B. van de, Pastor M. & Westen G.J.P. van (2023), Collaborative SAR modeling and prospective in vitro validation of oxidative stress activation in human HepG2 cells, Journal of Chemical Information and Modeling 63(17): 5433-5445.
- Béquignon O.J.M., Bongers B.J., Jespers W., IJzerman A.P., Water B. van de & Westen G.J.P. van (2023), Papyrus: a large-scale curated dataset aimed at bioactivity predictions, Journal of Cheminformatics 15(1): 3.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J.D., Gorostiola Gonzalez M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2023), Corrigendum to "Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism" [Biochem. Pharmacol. 208 (2023) 115399], Biochemical Pharmacology 209: 115540 (115450).
- Schoenmaker L., Béquignon O.J.M., Jespers W. & Westen G.J.P. van (2023), UnCorrupt SMILES: a novel approach to de novo design, Journal of Cheminformatics 15(1): 22.
- Sicho M., Luukkonena S., Maagdenberg H.W. van den, Schoenmaker L., Bequignon O.J.M. & Westen G.J.P. van (2023), DrugEx: deep learning models and tools for exploration of drug-like chemical space. [working paper].
- Liu Q., Stel W. van der, Noord V.E. van der, Leegwater H., Coban B., Elbertse K., Pruijs J.T.M., Béquignon O.J.M., Westen G.J.P. van, Dévédec S.E. le & Danen E.H.J. (2022), Hypoxia triggers TAZ phosphorylation in basal a triple negative breast cancer cells, International Journal of Molecular Sciences 23(17): 10119.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J., Gorostiola González M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2022), Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism, Biochemical Pharmacology 208: 115399.
- Béquignon O.J.M., Pawara G., Water B. van de, Cronin M.T.D. & Westen G.J.P. van (2021), Computational approaches for drug-induced liver injury (DILI) prediction: state of the art and challenges. In: Wolkenhauer O. (Ed.), Systems Medicine no. 2: Elsevier. 308-329.
- Janssen A.P.A., Hengst J.M.A. van, Béquignon O.J.M., Deng H., Westen G.J.P. van & Stelt M. van der (2019), Structure Kinetics Relationships and Molecular Dynamics Show Crucial Role for Heterocycle Leaving Group in Irreversible Diacylglycerol Lipase Inhibitors, Journal of Medicinal Chemistry 62(17): 7910-7922.