Monika Timmer
Analyst
- Name
- Dr. M. Timmer
- Telephone
- 071 5274636
- m.timmer.3@chem.leidenuniv.nl
Analyst
- Faculty of Science
- LIC
- Chemistry for Human Health
- Macromolecular Biochemistry
- Radojković M., Chikunova A., Koene S.F., Timmer M., Natarajan Sivanandam V., Boyle A.L. & Ubbink M. (2025), A glycine at position 105 leads to clavulanic acid and avibactam resistance in class A β-lactamases, The Journal of Biological Chemistry 301(7): 110347.
- Radojković M., Bruggeling van Ingen A., Timmer M. & Ubbink M. (2025), Stabilizing mutations enhance evolvability of BlaC β-lactamase by widening the mutational landscape, Journal of Molecular Biology 437(9): 168999.
- Saberi M., Chikunova A., Ben Bdira F., Cramer‐Blok A., Timmer M., Voskamp P. & Ubbink M. (2024), Bimodal substrate binding in the active site of the glycosidase BcX, FEBS Journal 291(19): 4222-4239.
- Sun J., Chikunova A., Boyle A.L., Voskamp P., Timmer M. & Ubbink M. (2023), Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase, International Journal of Biological Macromolecules 250: 126160.
- Alen I. van, Chikunova A., Zanten D.B. van, Block A.A. de, Timmer M., Brünle S. & Ubbink M. (2023), Asp179 in the class A β‐lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis, FEBS Journal 290: 4933-4949.
- Henneman B., Brouwer T.B., Erkelens A.M., Kuijntjes G.A.J.T., Emmerik C. van, Valk R.A. van der, Timmer M., Kirolos N., Ingen H. van, Noort S.J.T. van & Dame R.T. (2021), Mechanical and structural properties of archaeal hypernucleosomes, Nucleic Acids Research 49(8): 4338-4394.
- Chatterjee S.D. Zhou J. Dasgupta R. Cramer-Blok A.J. Timmer M. Stelt M. van der Ubbink M. (2021), Protein dynamics influence the enzymatic activity of phospholipase a/acyltransferases 3 and 4, Biochemistry 60(15): 1178-1190.
- Elings W., Chikunova A., Zanten D.B. van, Drenth R., Ahmad M.U.D., Blok A.J., Timmer M., Perrakis A. & Ubbink M. (2021), Two β-lactamase variants with reduced clavulanic acid inhibition display different millisecond dynamics, Antimicrobial Agents and Chemotherapy 65(8): e02628-20.
- Erkelens A.M., Henneman B., Brouwer T.B., Kuijntjes G.A.J.T., Emmerik C.L. van, Valk R.A. van der, Timmer M., Kirolos N.C.S., Ingen H. van & Noort S.J.T. van (2021), (A)Specific DNA binding of archaeal histones, the formation and positioning of hypernucleosomes, Biophysical Journal 120(3): 317a.
- Miao Q., Zurlo E., Bruin D. de, Wondergem J.A.J., Skinner S.P., Timmer M., Cramer A.J., Heinrich D.M., Overhand M. & Huber M.I. (2021), Corrigendum: a two-armed probe for in-cell DEER measurements on proteins (vol 26, pg 17128, 2020), Chemistry: a European Journal 27(23): 6994-6994.
- ElingsW., Gaur A., Blok A.J., Timmer M., Ingen H. van & Ubbink M. (2020), β-Lactamase of mycobacterium tuberculosis shows dynamics in the active site that increase upon inhibitor binding, Antimicrobial Agents and Chemotherapy 64(3): e02025-19.
- Miao Q., Zurlo E., Bruin D. de, Wondergem A.J., Timmer M., Blok A.J., Heinrich D.M., Overhand M., Huber M.I. & Ubbink M. (2020), A two‐armed probe for in‐cell DEER measurements on proteins, Chemistry: a European Journal 26(71): 17128-17133.
- Miao Q., Liu W.-M., Kock T., Blok A.J., Timmer M., Overhand M. & Ubbink M. (2019), A double-armed, hydrophilic transition metal complex as paramagnetic NMR probe, Angewandte Chemie (International Edition) 58(37): 13093-13100.
- Lescanne M., Ahuja P., Blok A., Timmer M., Akerud T. & Ubbink M. (2018), Methyl group reorientation under ligand binding probed by pseudocontact shift, Journal of Biomolecular NMR 71: 275-285.
- Elings W., Tassoni R., Schoot S.A. van der, Luu W., Kynast J.P., Dai L., Blok A.J., Timmer M., Florea B.I., Pannu N.S. & Ubbink M. (2017), Phosphate Promotes the Recovery of Mycobacterium tuberculosis beta-Lactamase from Clavulanic Acid Inhibition, Biochemistry 56(47): 6257-6267.
- Lescanne M., Skinner S.P., Blok A., Timmer M., Cerofolini L., Fragai M., Luchinat C. & Ubbink M. (2017), Methyl group assignment using pseudocontact shifts with PARAssign, Journal of Biomolecular NMR 69(4): 183-195.
- Skinner S.P., Liu W.M., Hiruma Y., Timmer M., Blok A., Hass M.A.S. & Ubbink M. (2015), Delicate conformational balance of the redox enzyme cytochrome P450cam, Proceedings of the National Academy of Sciences 112(29): 9022-9027.
- Liu W.M., Skinner S.P., Timmer M., Blok A., Hass M.A.S., Filippov D.V., Overhand M. & Ubbink M. (2014), A Two-Armed Lanthanoid-Chelating Paramagnetic NMR Probe Linked to Proteins via Thioether Linkages, Chemistry: a European Journal 20(21): 6256-6258.
- Guan Jia-Ying, Foerster Johannes M., Drijfhout Jan W., Timmer Monika, Blok Anneloes, Ullmann G. Matthias & Ubbink Marcellus (2014), An Ensemble of Rapidly Interconverting Orientations in Electrostatic Protein-Peptide Complexes Characterized by NMR Spectroscopy, ChemBioChem 15(4): 556-566.
- Scanu S., Foerster J.M., Timmer M., Ullmann G.M. & Ubbink M. (2013), Loss of electrostatic interactions causes increase of dynamics within the plastocyanin-cytochrome f complex, Biochemistry 52: 6615-6626.
- Liu W.M., Keizers P.H.J., Hass M.A.S., Blok A.J., Timmer M., Sarris A.J.C., Overhand M. & Ubbink M. (2012), A pH-Sensitive, Colorful, Lanthanide-Chelating Paramagnetic NMR Probe, Journal of the American Chemical Society 134(41): 17306-17313.