Mirjam Huizenga
Postdoc
- Name
- Dr. M.C.W. Huizenga
- Telephone
- +31 71 527 3539
- m.c.w.huizenga@lic.leidenuniv.nl
- ORCID iD
- 0000-0001-8313-0019
Postdoc
- Faculty of Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- Hassen A.K., Sicho M., Aalst Y.J. van, Huizenga M.C.W., Reynolds D.N.R., Luukkonen S.I.M., Bernatavicius A., Clevert D.-A., Janssen A.P.A., Westen G.J.P. van & Preuss M. (2025), Generate what you can make: achieving in-house synthesizability with readily available resources in de novo drug design, Journal of Cheminformatics 17: 41.
- Jesus C.H.A., Wirt J.L., Ferreira L.A., Hainline J., Huizenga M.C.W., Rems L., Makriyannis A., Stelt M. van der & Hohmann A.G. (2025), Acetaminophen attenuates pathological pain through a mechanism that requires CB1 cannabinoid receptors and the enzyme diacylglycerol lipase in mice, bioRxiv : the preprint server for biology : .
- Hentsch A., Guberman M., Radetzki S., Kaushik S., Huizenga M.C.W., Paul J., Schippers M., Benz J., Kuhn B., Heer D., Topp A., Esteves Gloria L., Walter A., Hochstrasser R., Wittwer M.B., Kries J.P. von, Collin L., Blaising J., Stelt M. van der, Lipstein N., Grether U. & Nazaré M. (2025), A highly selective and versatile probe platform for visualization of monoacylglycerol lipase, Angewandte Chemie (International Edition) 64(10): e202413405.
- Hentsch A., Guberman M., Radetzki S., Kaushik S., Huizenga M.C.W., He Y., Contzen J., Kuhn B., Benz J., Schippers M., Paul J., Leibrock L., Collin L., Wittwer M., Topp A., O'Hara F., Heer D., Hochstrasser R., Blaising J., Kries J.P. von, Mu L., Stelt M. van der, Mergenthaler P., Lipstein N., Grether U. & Nazaré M. (2025), Highly specific miniaturized fluorescent monoacylglycerol lipase probes enable translational research, Journal of the American Chemical Society 147(12): 10188-10202.
- Vliet D. van der, Klinkenberg A.X.Y., Platte R., Higgins K., Prokop S., Huizenga M.C.W., Kraaijevanger L., Egmond N. van, Straub V.M., Kole M.H.P., Pacher P., Katona I., Huitinga I. & Stelt M. van der (2025), Spatially resolved mapping of monoacylglycerol lipase activity in the brain, bioRxiv : the preprint server for biology : .
- Huizenga M.C.W. (10 September 2024), MAGL modulators: structure-guided optimisation and characterisation (Dissertatie. Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University). Supervisor(s) and Co-supervisor(s): Stelt M. van der, Janssen A.P.A. & Berg R.J.B.H.N. van den.
- Jiang M., Huizenga M.C.W., Mohr F.D., Amedi A., Bakker R., Berg R.J.B.H.N. van den, Deng H., Wel T. van der, Boeckel C.A.A. van & Stelt M. van der (2024), Structure-activity relationship studies of aryl sulfoxides as reversible monoacylglycerol lipase inhibitors, Journal of Medicinal Chemistry 67(14): 12331-12348.
- Jiang M., Huizenga M.C.W., Wirth J.L., Paloczi J., Amedi A., Berg R.J.B.H.N. van den, Benz J., Collin L., Deng H., Di X., Driver W.F., Florea B.I., Grether U., Janssen A.P.A., Hankemeier T., Heitman L.H., Lam T.W., Mohr F., Pavlovic A., Ruf I., Hurk H. van den, Stevens A.F., Vliet D. van der, Wel T. van der, Wittwer M.B., Boeckel C.A.A. van, Pacher P., Hohmann A.G. & Stelt M. van der (2023), A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence, Nature Communications 14(1): 8039.