Jurriaan Heming
PhD candidate
- Name
- Ing. J.J.A. Heming MSc
- Telephone
- 071 5272727
- j.j.a.heming@lic.leidenuniv.nl
- ORCID iD
- 0000-0002-9217-3616
PhD candidate
- Faculty of Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
- Heming J.J.A. (16 January 2026), Substrates and inhibitors to study and modulate ER-I α-glucosidase activity [Substrates and inhibitors to study and modulate ER-I α-glucosidase activity] (Dissertatie. Leiden Institute of Chemistry, Wiskunde en Natuurwetenschappen, Leiden University). Supervisor(s) and Co-supervisor(s): Overkleeft H., Artola Perez de Azanza M.E.
- Vieira Da Cruz A., Perraudin V., Minopoli N., Iacono R., Roig-Zamboni V., Bossio A., Tangara S., Fayolle M., Kanazawa A., Philouze C., Tarallo A., Heming J.J.A., Artola Perez de Azanza M.E., Behr J.-B., Overkleeft H.S., Moracci M., Sulzenbacher G., Parenti G. & Py S. (2025), C-branched iminosugars as selective pharmacological chaperones of lysosomal α-glucosidase for the treatment of pompe disease, Journal of Medicinal Chemistry 68(18): 19269-19286.
- Ofman T.P., Heming J.J.A., Nin-Hill A., Küllmer F., Moran E., Bennett M., Steneker R., Klein A.M., Ruijgrok G., Kok K., Armstrong Z.W.B., Aerts J.M.F.G., Marel G.A. van der, Rovira C., Davies G.J., Artola M.E., Codée J.D.C. & Overkleeft H.S. (2024), Conformational and electronic variations in 1,2‐ and 1,5a‐Cyclophellitols and their impact on retaining α‐glucosidase inhibition, Chemistry: a European Journal 30(31): e202400723.
- Thaler M., Ofman T.P., Kok K., Heming J.J.A., Moran E., Pickles I., Leijs A.A., Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruijgrok G., Armstrong Z.W.B., Salgado-Benvindo C., Ninaber D.K., Snijder E.J., Boeckel C.A.A. van, Artola Perez de Azanza M.E., Davies G.J., Overkleeft H.S. & Hemert M.J. van (2024), Epi-Cyclophellitol cyclosulfate, a mechanism-based endoplasmic reticulum α-Glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses, ACS Central Science 10(8): 1594-1608.