Gerard Mulder
Professor emeritus of Toxicology
- Name
- Prof.dr. G.J. Mulder
- Telephone
- +31 71 527 4406
- g.mulder@lacdr.leidenuniv.nl
Prof. Dr. Gerard J. Mulder is former Head of the Departement of Toxicology.
Professor emeritus of Toxicology
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Algemeen
- Burg D., Riepsaame J., Pont C., Mulder G. & Water B. van de (2006), Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling, Biochemical Pharmacology 71(3): 268-277.
- Burg D., Riepsaame J., Mulder G.J. & Water B. van de (2006), Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling, Biochemical Pharmacology 71(3): 268-277.
- Lekkerkerker J.F., Schobben A.F., Dissel J.T. van, Hekster Y.A., Hoes A.W., Mulder G.J., Neef C., Peeters M.F., Ree J.M. van, Rosmalen C.F.H., Schellekens H. & Silberbusch J. (2005), Geen plaats voor selectieve serotonineheropnameremmers (SSR's) bij depressieve kinderen en adolescenten, Nederlands Tijdschrift voor Geneeskunde 149: 1870-1872.
- Lekkerkerker J.F., Schobben A.F., Dissel J.T. van, Hekster Y.A., Hoes A.W., Mulder G.J., Neef C. & Peeters M.F. (2005), Selective serotonin reuptake inhibitors (SSRI¿s) are not indicated for children and adolescents with depression, Nederlands Tijdschrift voor Geneeskunde 149(33): 1870-1871.
- Huber W.W., Teitel C.H., Coles B.F., King R.S., Wiese F.W., Kaderlik K.R., Casciano D.A., Shaddock J.G., Mulder G.J., Iett K.F. & Kadlubar F.F. (2004), Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities, Environmental and Molecular Mutagenesis 44: 265-276.
- Rothbarth J., Koevoets C., Tollenaar R.A.E.M., Tilby M.J., Velde C.J.H. van de, Mulder G.J. & Kuppen P.J.K. (2004), Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo, Biochemical Pharmacology 67: 1771-1778.
- Rothbarth J., Koevoets C., Tollenaar R.A.E.M., Tilby M.J., Velde C.J.H. van de, Mulder G.J. & Kuppen P.J.K. (2004), Immunochemical detection of melphalan-DNA adducts in colon cancer tissue in vitro and human colorectal liver tumour tissue in vivo, Biochemical Pharmacology 67: 1771-1778.
- Rothbarth J., Tollenaar R.A.E.M., Schellens J.H., Nortier J.W.R., Schultze Kool L.J., Kuppen P.J.K., Mulder G.J. & Velde C.J.H. van de (2004), Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives, European Journal of Cancer 40: 1812-1824.
- Velthuis J.H., Bont H.J.G.M. de, Medema J.P., Kuppen P.J.K., Mulder G.J. & Nagelkerke J.F. (2003), Interleukin-2 activated NK-cells do not use the CD96-L and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells, Immunobiology 207: 115-127.
- Sparidans R.W., Silvertand L., Dost F., Rothbarth J., Mulder G.J., Schellens J.H. & Beijnen J.H. (2003), Simple high-performance liquid chromatographic assay for melphalan in perfusate, rate liver and tumour tissue, Biomed. Chromatogr. 17: 458-464.
- Velthuis J.H., Stitzinger M., Aalbers R.I.J.M., Bont H.J.G.M. de, Mulder G.J., Kuppen P.J.K. & Nagelkerke J.F. (2003), Rat colon carcinoma cells that survived systemic immune surveillance are less sensitive to NK-cell mediated apoptosis, Clinical Experimental Metastasis 20: 713-721.
- Rothbarth J., Woutersen R.A., Sparidans R.W., Velde C.J.H. van de & Mulder G.J. (2003), Melphalan antitumor efficacy and hepatotoxicity: the effect of variable infusion duration in the hepatic artery, Journal of Pharmacology and Experimental Therapeutics 305: 1098-1103.
- Hoetelmans R.M.W., Vahrmeijer A.L., Vlierberghe R.L.P. van, Keijzer R., Velde C.J.H. van de, Mulder G.J. & Dierendonck J.H. van (2003), The role of various Bcl-2 domains in the anti-proliferative effect and modulation of cellular glutathione levels: a prominent role for the BH4 domain, Cell Proliferation 36: 35-44.
- Rothbarth J., Pijl M.E.J., Tollenaar R.A.E.M., Tijl F., Ivancev G., Mulder G.J., Kuppen P.J.K., Velde C.J.H. van de & Schultze Kool L.J. (2003), An experimental minimally invasive perfusion technique for the treatment of liver metastases, European Journal of Surgical Oncology 29: 757-763.
- Velthuis J.H., Bont H.J., Medema J.P., Kuppen P.J.K., Mulder G.J. & Nagelkerke J.F. (2003), Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells, Immunobiology 207(2): 115-127.
- Hoetelmans R.M.W., Vahrmeijer A.L., Mulder G.J., Velde C.J.H. van de, Nagelkerke J.F. & Dierendonck J.H. van (2003), Bcl-2 overexpression does not prevent but retards adriamycin toxicity in CC531 coloncarcinoma cells, Chemotherapy 49: 309-315.
- Rothbarth J., Vahrmeijer A.L. & Mulder G.J. (2002), Modulation of cytostatic efficacy of melphalan by glutathione: mechanisms and efficacy, Chemico-Biological Interactions 140: 93-107.
- Burg D., Filippov D.V., Hermanns R.C.A., Marel G.A. van der, Boom J.H. van & Mulder G.J. (2002), Peptidomimetic glutathione analogues as novel γGT stable GST inhibitors, Bioorganic & Medicinal Chemistry 10: 195-205.
- Huigsloot M., Tijdens R.B., Mulder G.J. & Water B. van de (2002), Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary (MTLn3) cells, Journal of Biological Chemistry 277(39): 35869-35879.
- Velthuis J.H., Rouschop K.M., Bont H.J.G.M. de, Mulder G.J. & Nagelkerke J.F. (2002), Distinct intracellular signaling in Tumor Necrosis Factor-related Apoptosis-inducing Ligand- and CD95 Ligand-mediated apoptosis, Journal of Biological Chemistry 277(27): 24631-24637.
- Schrier S.M., Florea B.I., Mulder G.J., Nagelkerke J.F. & IJzerman A.P. (2002), Apoptosis induced by extracellular ATP in the mouse neuroblastoma cell line N1E-115:studies on involvement of P2 receptors and adenosine, Biochemical Pharmacology 63: 1119-1126.
- Schrier S.M., Florea B.I., Mulder G.J., Nagelkerke J.F. & IJzerman A.P. (2002), Apoptosis induced by extracellular ATP in the neuroblastoma cell line NIE-115: studies on involvement of P2 receptors and adenosine, Biochemical Pharmacology 63: 1119-1126.
- Blom W.M., Bont H.J.G.M. de, Mulder G.J. & Nagelkerke J.F. (2002), The role of calpains in apoptopic changes in isolated hepatocytes after attack by Natural Killer cells, Environm. Toxicol. Pharmacol. 11: 159-165.
- Burg D., Filippov D.V., Hermanns R.C.A., Marel G.A. van der, Boom J.H. van & Mulder G.J. (2002), Peptidomimetic glutathione analogues as novel gamma GT stable GST inhibitors, Bioorganic & Medicinal Chemistry 10: 195-205.
- Burg D., Hameetman L., Filippov D.V., Marel G.A. van der & Mulder G.J. (2002), Inhibition of glutathione S-transferase in rat hepatocytes by a glycine-tetrazole modified S-alkyl-GSH analogue, Bioorganic and Medicinal Chemistry Letters 12: 1579-1582.
- Rothbarth J., Sparidans R.W., Beijnen J.H., Schultze Kool L.J., Putter H., Velde C.J.H. van de & Mulder G.J. (2002), Reduced liver uptake of arterially infused melphalan during retrograde rat liver perfusion with unaffected liver tumor uptake, Journal of Pharmacology and Experimental Therapeutics 303: 736-740.
- Rothbarth J., Sparidans R.W., Beijnen J.H., Kool L.J.S., Putter H., Velde C.J.H. van de & Mulder G.J. (2002), Reduced liver uptake of arterially infused melphalan during retrograde rat liver perfusion with unaffected liver tumor uptake, Journal of Pharmacology and Experimental Therapeutics 303(2): 736-740.
- Burg D. & Mulder G.J. (2002), Glutathione conjugates and their synthetic derivatives as inhibitiors of glutathione-dependent enzymes involved in cancer and drug resistance, Drug Metabolism Reviews 34: 821-863.
- Burg D., Wielinga P.R., Zelcer N., Saeki T., Mulder G.J. & Borst P. (2002), Inhibition of the multidrug reistance protein 1 (MRPI) by peptidomimetic glutatione-conjugate analogues, Molecular Pharmacology 62: 1160-1166.
- Rothbarth J., Vahrmeijer A.L. & Mulder G.J. (2002), Modulation of cytostatic efficacy of mephalan by glutathione: mechanisms and efficacy, Chem. Biol. Interact. 140: 93-107.
- Blom W.M., Bont H.J., Meijerman I., Kuppen P.J.K., Meulen M.C. van der, Mulder G.J. & Nagelkerke J.F. (2001), Remodeling of the actin cytoskeleton of target hepatocytes and NK cells during induction of apoptosis, Cell Motel Cytoskeleton 49: 78-92.
- Huigsloot M., Tijdens R.B., Mulder G.J. & Water B. van de (2001), Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells, Biochemical Pharmacology 62(8): 1087-1097.
- Water B. van de, Tijdens R.B., Verbrugge A., Huigsloot M., Dihal A.A., Stevens J.L., Jaken S. & Mulder G.J. (2000), Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells, Journal of Biological Chemistry 275(33): 25805-25813.
- Vahrmeyer A.L., Dierendonck J.H. van, Keizer H.J., Beijnen J.H., Tollenaar R.A.E.M., Pijl M.E.J., Marinelli A.W.K.S., Kuppen P.J.K., Bockel J.H. van, Mulder G.J. & Velde C.J.H. van de (2000), Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacological evaluation of treatment with high dose melphalan in patients with high dose melphalan in patients with colorectal cancer confined to the liver, British Journal of Cancer 82(9): 1539-1546.
- Vahrmeijer A.L., Hoetelmans R.W.M., Mulder G.J., Schutrups J., Vlierberghe R.L.P. van, Velde C.J.H. van de & Dierendonck J.H. van (2000), Development of resistance to glutathione depletion-induced cell death in CC531 colon carcinoma cells: association with increased expression of bcl-2, Biochemical Pharmacology 59: 1557-1562.
- Vahrmeyer A.L., Dierendonck J.H. van, Schutrups J., Velde C.J.H. van de & Mulder G.J. (1999), Effect of glutathione depletion on inhibition of cell cycle progression and induction of apoptosis by melphalan in human colorectal cancer cells, Biochemical Pharmacology 58: 655-664.
- Vahrmeyer A.L., Dierendonck J.H. van, Schutrups J., Velde C.J.H. van de & Mulder G.J. (1999), Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat; enhanced tumor glutathione depletion by infusion of BSO in the hepatic artery, Cancer Chemotherapy and Pharmacology 44: 111-116.
- Blom W.M., Bont H.J.G.M. de, Meijerman I., Kuppen P.J.K., Mulder G.J. & Nagelkerke J.F. (1999), Interleukin-2-activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes, Hepatology 29: 785-792.
- Ouwerkerk-Mahadevan S. & Mulder G.J. (1998), Inhibition of glutathione conjugation in the rat in vivo analogues of glutathione conjugates, Chemico-Biological Interactions 111/112: 163-176.
- Vahrmeijer A.L., Dierendonck J.H. van, Schutrups J., Velde C.J.H. van de & Mulder G.J. (1998), Effect of Glutathione Depletion on Inhibition of Cell Cycle Progression and Induction of Apoptosis by Melphalan in Human Colorectal Cancer Cells, Biochemical Pharmacology : .
- Mulder G.J. (1998), The Netherlands. In: Wexler P. (Ed.), Information Resources in Toxicology, 3rd Edition. Amsterdam: IOS Press.
- Gijssel H.E. van, Gijlswijk R.P.M. van, Haas R.R., Stark C., Mulder G.J. & Meerman J.H.N. (1998), Immunohistochemical visualisation of wildtype p53 protein in paraffin-embedded rat liver using tyramine amplification: zonal distribution of p53 protein after N-hydroxy-2-acetylaminofluorene administration, Carcinogenesis 19: 219-222.
- Vahrmeijer A.L., Dierendonck J.H. van, Schutrups J., Velde C.J.H. van de & Mulder G.J. (1998), Potentiation of the cytostatic effect of melphalan on colorectal cancer hepatic metastases by infusion of buthionine sulfoximine (BSO) in the rat, Cancer Chemotherapy and Pharmacology : .
- Kruidering M., Water B. van de, Zhan Y., Baelde J.J., Heer E., Mulder G.J., Stevens J.L. & Nagelkerke J.F. (1998), Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro, Cell Death & Differentiation 5(7): 601-614.
- Meijerman I., Blom W.M., Bont H.J.G.M. de, Mulder G.J. & Nagelkerke J.F. (1998), Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways, Toxicology and Applied Pharmacology : .
- Mulder G.J. (1998), Glucuronidation and Aneasthesia. Baillière's Clinical Anesthesiology. In: Bovill J. (Ed.), Drug Interactions. London, UK: Bailliëre & Tindall. 229-246.
- Kruidering M., Water B. van de, Heer E. de, Mulder G.J. & Nagelkerke J.F. (1997), Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain, Journal of Pharmacology and Experimental Therapeutics 280(2): 638-649.
- Mulder G.J., Dreef-van der Meulen H.C., Feron V.J., Mohn G.R., Noordam P.C., Roelfzema H., Swaen G.M.H., Verbeek A.L.M., Verschuuren H.G., Vogel E.W., Zorge J.A. van & Vliet P.W. van (1997), Health Council of the Netherlands Committee 246 - Benzene, Health Council of the Netherlands 29: 1-46.
- Water B. van de, Zoeteweij J.P., Bont H.J.G.M. de, Mulder G.J. & Nagelkerke J.F. (1994), Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine, Journal of Biological Chemistry 269(20): 14546-14552.
- Water B. van de, Zoetewey J.P., Bont H.J. de, Mulder G.J. & Nagelkerke J.F. (1993), The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine, Biochemical Pharmacology 45(11): 2259-2267.
- Zoeteweij J.P., Water B. van de, Bont H.J.G.M. de, Mulder G.J. & Nagelkerke J.F. (1993), Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium, Journal of Biological Chemistry 268(5): 3384-3388.
- Zoeteweij J.P., Water B. van de, Bont H.J. de, Mulder G.J. & Nagelkerke J.F. (1992), Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes, Biochemical Journal 288(1): 207-213.
- Nagelkerke J.F., Water B. van de, Twiss I.M., Zoetewey J.P., Bont H.J. de, Dogterom P. & Mulder G.J. (1991), Role of microtubuli in secretion of very-low-density lipoprotein in isolated rat hepatocytes: early effects of thiol reagents, Hepatology 14(6): 1259-1268.