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Frits Rosendaal

Professor Clinical Epidemiology

Name
Prof.dr. F.R. Rosendaal
Telephone
+31 71 526 4037
E-mail
f.r.rosendaal@lumc.nl

Frits Rosendaal is professor of Clinical Epidemiology and chairman of the department of Clinical Epidemiology in the LUMC. His research is into causes of cardiovascular disease. In 2003 he received the Spinoza prize, the highest scientific award in the Netherlands. He is elected fellow of the Royal Academy of Science and Arts, as well as of the German Academy Leopoldina. In 2011 he was awarded a honorary doctorate of the University of Paris Descartes. He is Editor in Chief of the prestigious Journal of Thrombosis and Haemostasis, member of Council of the International Society on Thrombosis and Haemostasis, member of the Central Committee of Research on Humans (CCMO), member of the Committee on publication ethics (COPE), member of the Integrity Working party of the LERU universities, and co-chairman of the Scientific Integrity Committee of the University Leiden and the LUMC. He is visiting professor at the Universita degli Studi di Milano in Milan, Italy, and the Norges Arktiske Universitet in Tromsø, Norway.

More information about Frits Rosendaal

Frits Rosendaal is professor of Clinical Epidemiology and chairman of the department of Clinical Epidemiology in the LUMC. His research is into causes of cardiovascular disease. In 2003 he received the Spinoza prize, the highest scientific award in the Netherlands. He is elected fellow of the Royal Academy of Science and Arts, as well as of the German Academy Leopoldina. In 2011 he was awarded a honorary doctorate of the University of Paris Descartes. He is Editor in Chief of the prestigious Journal of Thrombosis and Haemostasis, member of Council of the International Society on Thrombosis and Haemostasis, member of the Central Committee of Research on Humans (CCMO), member of the Committee on publication ethics (COPE), member of the Integrity Working party of the LERU universities, and co-chairman of the Scientific Integrity Committee of the University Leiden and the LUMC. He is visiting professor at the Universita degli Studi di Milano in Milan, Italy, and the Norges Arktiske Universitet  in Tromsø, Norway.

Cardiovascular disease

The department of Clinical Epidemiology studies causes of diseases, optimal treatment strategies and complications of treatment in humans. This includes research into causes, prevention and treatment of thrombosis (blood clots, as in deep vein thrombosis, pulmonary embolism and myocardial infarction), the optimal treatment of haemophilia, and into diseases associated with overweight and obesity. The programme encompasses studies into genetic causes of disease, to studies of side effects of drugs such as oral contraceptives, to randomised studies of treatment effects.

Definitive conclusions on causes of disease or effects of treatment in humans can only be reached by studies in people. However, people are all different, have different genes, different habits and a different life style. This has to be taken into account in the research by choosing the optimal study design, and using the appropriate statistical techniques. The research of the department of Clinical Epidemiology, usually performed in collaboration with clinical departments, therefore usually includes hundreds or thousands of individuals. The department has strong methodological expertise and advises others on methodology.

Academic career

Frits Rosendaal studied medicine at the Erasmus University in Rotterdam and obtained his medical degree with honours in 1985. In 1989 he obtained his PhD at Leiden University, with Prof.  Ernest Briët as promotor. He was appointed as professor of Clinical Epidemiology in 1997, and became head of the department in 1999. From 2007 to 2010 he also chaired the department of Thrombosis and Haemostasis.

His research is mainly focused on causes of cardiovascular disorders. He initiated and led several epidemiological studies, such as LETS and MEGA, that led to the discovery of a large numbers of causes of thrombosis, such as Factor V Leiden.  An important finding was that some oral contraconceptive drugs, notably those from the 3rd generation, were associated with an excess risk of venous thrombosis. He takes part in several large international consortia that search for genetic causes of several frequent disorders. He leads the national Hemophilia in the Netherlands projects, and is mainly involved in studies into the occurrence of neutralising antibodies in haemophilia (inhibitors), that severely complicate treatment. Recently he showed that this complications occurs more often with coagulation factors produced by recombinant techniques than from donated human blood. He is principal investigator of the NEO-study (Netherlands Epidemiology of Obesity) in which 6700 individuals with overweight have been extensively examined and are followed through time.

Prizes and honourable appointments

Frits Rosendaal received several prestigious awards, such as the C.J. Kokprijs from Leiden University (1993), the Millennium Prize from the Universiteit of Trondheim, Norway (1999), de CARIM prize of the University of Maastricht (2002), de Spinozaprijs (2002), the Sol Sherry Award of the International Society on Thrombosis and Haemostasis (2003), the Distinguished Career Award of the International Society on Thrombosis and Haemostasis (2005), the Ham-Wasseman lecture of the American Society of Hematology, and an honorary doctorate from the University of Paris Descartes. He is elected fellow of the Royal Academy of Science and Arts (2008) and of the German Academy Leopoldina (2011).

More information:

NEO-website
Video Why me (Short version)
Video Why me (Extended version)

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Professor Clinical Epidemiology

  • Faculteit Geneeskunde
  • Divisie 2
  • Klinische Epidemiologie

Work address

LUMC Main Building
Albinusdreef 2
2333 ZA Leiden
Room number C07088

Contact

  • Centrale Commssie Mensgebonden Onderzoek (CCMO) Lid
  • Committee on Publication Ethics COPE Council Member
  • journal of thrombosis and haemostasis hoofdredacteur
  • Universiteit van Tromsø Affiliate Professor
  • Università degli Studi di Milano Visiting professor, IRRCS Ca Grande Ospedale

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