Chao Du
Education and research technician
- Name
- Dr. C. Du
- Telephone
- +31 71 527 4947
- c.du@biology.leidenuniv.nl
- ORCID iD
- 0000-0003-3447-5293
I am interested in system-biology study of Streptomyces development. The developmental process of multicellular bacteria contains a high level of complexity, and it is related to various bio-activities. My study focuses on three aspects of this process, morphological differentiation, antibiotic production, and Streptomyces’ response to plant hormone.
Supervisor(s)
Education and research technician
- Science
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Zhong X., Nicolardi S., Ouyang R., Wuhrer M., Du C., Wezel G. van, Vijgenboom E., Briegel A. & Claessen D. (2024), CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex, Applied and Environmental Microbiology 90(4): e02087.
- Hulst M.B., Zhang L., Heul H.U. van der, Du C., Elsayed S.S.M.A., Koroleva A., Grocholski T., Wander D.P.A., Metsä-Ketelä M., Neefjes J.J.C. & Wezel G.P. (2024), Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines, Frontiers in Bioengineering and Biotechnology 12: 1363803.
- Bergeijk D.A. van, Augustijn H.E., Elsayed S.S.M.A., Willemse J.J., Carrion Bavo V.J., Du C., Urem M., Grigoreva L.V., Cheprasov M.Y., Grigoriev S., Jansen H., Wintermans B., Budding A.E., Spaink H.P., Medema M.H. & Wezel G.P. van (2024), Taxonomic and metabolic diversity of Actinomycetota isolated from faeces of a 28,000‐year‐old mammoth, Environmental Microbiology 26(2): e16589.
- Terlouw B.R., Blin K., Navarr-Munoz J.C., Avalon N.E., Chevrette M.G., Egbert S., Lee S., Meijer D., Recchia M.J.J., Reitz Z.L., Santen J.A. van, Selem-Mojica N., Torring T., Zaroubi L., Alaniary M., Aleti G., Aguilar C., Al-Salihi S.A.A., Augustijn H.E., Avalar-Rivas J.A., Avitia Dominguez L.A., Barona Gomez F., Bernaldo-Agüero J., Bielinski V.A., Biermann F., Booth T.J., Carrion Bravo V.J., Castelo-Branco R., Chagas F.O., Cruz-Moreles P., Du C., Duncan K.R., Gavriilidou A., Gayrard D., Gutiérez-Garcia K., Haslinger K., Helfrich E.J.N., Hooft J.J.J. van der, Jati A.P., Kalkreuter E., Kalyvas N., Kang K.B., Kautsar S., Kim. W., Kunjapur A.M., Li Y.X., Lin G., Loureiro C., Louwen J.J.R., Louwen N.L.L., Lung G., Parra J., Philmus B., Purmohsenin B., Prong L.J.U., Rego A., Rex D.A.B., Robinson S., Rosas Becerra L.R., Roxborough E.T., Schorn M.A., Scobie D.J., Singh K.S., Sokolova N., Tang X., Udwary D., Vigneshwari A., Vind K., Vromans S.P.J.M., Waschulin V., Williams S.E., Winter J.M., Witte T.E., Xie H., Yang D., Yu J., Zdouc M., Zhong Z., Collemare J., Linington R.G., Weber T. & Medema M.H. (2023), MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters, Nucleic Acids Research 51(D1): D603-D610.
- Meij A. van der, Elsayed S.S.M.A., Willemse J.J., Du C., Wood T.M., Martin N.I., Raaijmakers J.M. & Wezel G.P. van (2023), The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes, 89(11): e01239-23.
- Li C, Urem M., Du C., Zhang L. & Wezel G.P. van (2023), Systems-wide analysis of the ROK-family regulatory gene rokL6 and its role in the control of glucosamine toxicity in Streptomyces coelicolor, 89(12): e01674-23.
- Bergeijk D.A. van, Elsayed S.S.M.A., Du C., Nuñez Santiago I., Roseboom A.M., Zhang L., Carrion Bravo V.J., Spaink H.P. & Wezel G.P. van (2022), The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces, Communications Chemistry 5: 14.
- Machushynets N.V., Elsayed S.S.M.A., Du C., Siegler M.A., Cruz M. de la, Genillou O., Hankemeier T. & Wezel G.P. van (2022), Discovery of actinomycin L, a new member of the actinomycin family of antibiotics, Scientific Reports 12: 2813.
- Du C., Willemse J.J., Erkelens A.M., Carrion Bravo V.J., Dame R.T. & Wezel G.P. van (2022), System-wide analysis of the GATC-binding nucleoid-associated protein Gbn and its impact on Streptomyces development, mSystems 7(3): e00061-22.
- Zhang Z., Du C., De Barsy F., Liem M., Liakopoulos A., Wezel G.P. van, Choi Y.H., Claessen D. & Rozen D.E. (2020), Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation, Science Advances 6(3): eaay5781.
- Du C. (9 December 2020), Multi-omics studies of the control of growth and antibiotic production of streptomyces (Dissertatie. Institute of Biology (IBL), Faculty of Science, Leiden University). Supervisor(s): Wezel G.P. van & Raaijmakers J.M.
- Xiao X., Elsayed S.S.M.A., Wu C., Heul H.U. van der, Metsä-Ketelä M., Du C., Prota A.E., Chen C.C., Liu W., Guo R.T., Abrahams J.P. & Wezel G.P. van (2020), Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway, ACS Chemical Biology 15(9): 2529-2538.
- Kloosterman A.M., Cimermancic P., Elsayed S.S.M.A., Du C., Hadjithomas M., Donia M.S., Fischbach M.A., Wezel G.P. van & Medema M.H. (2020), Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides, PLoS Biology 18(12): e3001026.
- Sulheim S., Kumelj T., Dissel D. van, Salehzadeh-Yazdi A., Du C., Wezel G.P. van, Nieselt K., Almaas E., Wentzel A. & Kerkhoven E.J. (2020), Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production, iScience 23(9): 101525.
- Chao D. & Wezel G.P. van (2018), Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline, Proteomics 18(18): 1700332.
- Wu C., Du C., Ichinose K., Choi Y.H. & Wezel G.P. van (2017), Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow, Journal of Natural Products 80(2): 269-277.