Universiteit Leiden

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Annette van der Helm-van Mil

Name
Prof.dr. A.H.M. van der Helm-van Mil
Telephone
+31 71 526 1290
E-mail
a.h.m.van_der_helm@lumc.nl

Annette van der Helm is professor in Rheumatology, in particular early arthritis. She works as internist, rheumatologist at the department of rheumatology of the Leiden University Medical Center, the Netherlands. She is also appointed as professor to the department of rheumatology of the Erasmus Medical Center, Rotterdam, the Netherlands. She received several prizes and personal grants on the national (NWO Vidi and ‘Klinisch Fellow’ grant) en international level (ERC Starting Grant).

More information about Annette van der Helm-van Mil

Annette van der Helm is professor in Rheumatology, in particular early arthritis. She works as internist, rheumatologist at the department of rheumatology of the Leiden University Medical Center, the Netherlands. She is also appointed as professor to the department of rheumatology of the Erasmus Medical Center, Rotterdam, the Netherlands. She received several prizes and personal grants on the national (NWO Vidi and ‘Klinisch Fellow’ grant) en international level (ERC Starting Grant).

Rheumatology

Rheumatoid Arthritis (RA) is a chronic inflammatory disease that results in joint pain, disability and limitations at work. Currently, severe joint destruction can be prevented by early and powerful medications. However RA is still a chronic disease that patients suffer from for life. The work of Van der Helm is aimed at preventing the chronic disease phase of RA or shortening the disease duration.

The earliest phases of disease development, in particular the phase preceding the occurrence of clinically evident arthritis, is crucial to achieve this aim, as the biologic processes in the very early phases are crucial for the subsequent disease course. In team work, using laboratory as well as advanced imaging studies, the development of RA is being studied. Ultimately this results in the identification of targets for very early targeted intervention, aiming at prevention. Allowing early access to rheumatologic care is crucial. Another core of research is developing accurate methods to predict which persons with recent onset joint pain (arthralgia) will develop RA. Van der Helm also supervises a region-wide proof-of-concept trial that studies whether chronic arthritis and RA can be prevented by very early treatment in initiated in the disease phase of arthralgia. In sum the research is aimed at early access to medical care, timely diagnosis and very early personalized intervention

Academic career

Annette van der Helm-van Mil started studying Medicine at the University of Leiden in 1993 and obtained her medical degree in 1998 (cum laude). In 2005 she got her qualification as internist and in 2006 she was ratified as rheumatologist.

She obtained her Ph.D. degree in 2006 (cum laude) on the thesis "Genetics, Autoantibodies and Clinical Features in Understanding and Predicting Rheumatoid Arthritis“ at the Leiden University .

Since 2006 she is appointed at the department of Rheumatology of the LUMC. She was head of the outpatient clinic from 2006 till 2015. In November 2015 she was appointed as professor at the department of Rheumatology at the LUMC and also the EMC. The title of her inaugural lecture, held at Oct 14, 2016, was  ‘the changing phenotype of RA’.

Currently she is supervising the Leiden Early Arthritis Cohort, the Clinically Suspect Arthralgia cohort and the TREAT EARLIER trial, the latter two projects are being rolled across the south-west part of the Netherlands, from the LUMC and EMC.

She is associate editor of RMD Open, published >200 peer reviewed articles, and authored >10 textbook chapters. Van der Helm is active in several European consortia and supervised the development of the EULAR definition of arthralgia suspicious for progression to RA. 

Prizes and honourable appointments

Van der Helm received the EULAR Young Investigator award, the Prof.dr Goslingsprize (prize for best scientific research of the Dutch society of rheumatology), and  the Marie-Parijs prize (research prize from the Leiden University). In addition she received several personal grants, among which a Klinisch Fellow grant of NWO (2007), a Vidi grant of NOW (2012), and ERC Starting Grant (2016).

  • Faculteit Geneeskunde
  • Divisie 2
  • Reumatologie

Work address

LUMC Main Building
Albinusdreef 2
2333 ZA Leiden
Room number C-1-R

Contact

  • E-wise Medical hoofdredacteur
  • Netwerk Natuurgerichte Gezondheid lid NNG standaard artritis

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