Key publications of the Cardiovascular Pharmacology group

• Delfos L, Depuydt MAC, Chemaly M, Coyle S, Schaftenaar FH, van Santbrink PJ, Lindenbergh PP, Bernabé Kleijn MNA, Costello C, Power CA, Coll R, Peace A, Gregory-Ksander M, Foks AC, Kuiper J, McGilligan V, Bot I,  NLRP3 Inflammasome Inhibition by the Novel Bispecific Antibody InflamAb Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice.  JACC Basic Transl Sci. 2025 Jun;10(6):826-840. 
• Hemme E, Depuydt MAC, van Santbrink PJ, Wezel A, Smeets HJ, Foks AC, Kuiper J, Bot I,  Leukemia inhibitory factor receptor inhibition by EC359 reduces atherosclerotic stenosis grade in Ldlr-/- mice.  Eur J Pharmacol. 2024 Dec 15;985:177121. 
• Bot I, Delfos L, Hemme E, Bernabé Kleijn MNA, van Santbrink PJ, Foks AC, Kovanen PT, Jouppila A, Lassila R, Treatment with APAC, a dual antiplatelet anticoagulant heparin proteoglycan mimetic, limits early collar-induced carotid atherosclerotic plaque development in Apoe-/- mice. Atherosclerosis. 2024 Oct;397:118567 

• Hemme E., Biskop D., Depuydt M.A.C., Smit V., Delfos L., Bernabé Kleijn M.N.A., Foks A.C., Kuiper J. & Bot I. (2023), Bruton's Tyrosine Kinase inhibition by Acalabrutinib does not affect early or advanced atherosclerotic plaque size and morphology in Ldlr-/- mice, Vascul Pharmacol. 2023 Jun;150:107172

• Depuydt M.A.C., Schaftenaar F.H., Prange K.H.M. Boltjes A., Hemme E., Delfos L., de Mol J., de Jong M.J.M., Bernabé Kleijn M.N.A., Peeters J.A.H.M., Goncalves L., Wezel A., Smeets H.J., de Borst G.J., Foks A.C., Pasterkamp G., de Winther M.P.J., Kuiper J., Slütter B., & Bot I. (2023), Single-cell T cell Receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells, Nature Cardiovascular Research. 2023;2:112-125

• Depuydt M.A.C., Prange K.H.M., Slenders L., Örd T., Elbersen D., Boltjes A., de Jager S.C.A., Asselbergs F.W., de Borst G.J., Aavik E., Lönnberg T., Lutgens E., Glass C.K., den Ruijter H.M., Kaikkonen M.U., Slütter B., van der Laan S.W., Yla-Herttuala S., Mokry M., Kuiper J., de Winther M.P.J., Pasterkamp G. & Bot I. (2020), Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics, Circ Res. 2020 Nov 6;127(11):1437-1455
• Kritikou E., Depuydt M.A.C., Vries M.R. de, Mulder K.E., Govaert A.M., Smit M.D., Duijn J. van, Foks A.C., Wezel A., Smeets H.J., Slütter B., Quax P.H.A., Kuiper J. & Bot I. (2019), Flow Cytometry-Based Characterization of Mast Cells in Human Atherosclerosis, Cells 8(4): 334.
• Indhirajanti S., Daele P.L.A. van, Bos S., Mulder M.T., Bot I. & Lennep J.E.R. van (2018), Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels, Atherosclerosis 268: 152-156.
• Tsiantoulas D., Bot I., Ozsvar-Kozma M., Goederle L., Perkmann T., Hartvigsen K., Conrad D.H., Kuiper J., Mallat Z. & Binder C.J. (2017), Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency, CIRCULATION RESEARCH 120(1): 78-84.
• Shi G.P., Bot I. & Kovanen P.T. (2015), Mast cells in human and experimental cardiometabolic diseases, Nature reviews. Cardiology 12: 643-658.