Universiteit Leiden

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Research project

MS@Work study

What are the main predictors of work participation in patients with multiple sclerosis?

Contact
Karin van der Hiele
Funding
Nationaal MS fonds
 
Teva Pharma Nederland Teva Pharma Nederland
 
ZonMw TopZorg ZonMw TopZorg
Partners

National Multiple Sclerosis Foundation
St. Elisabeth Hospital Tilburg
University of Humanistic studies
MS4 Research Institute
Van Lieshout Arbo Advies

Multiple Sclerosis (MS) is a chronic, inflammatory, demyelinating disease affecting the Central Nervous System. MS is the most common cause of neurological disability in young and middle-aged adults. At this stage in life most people are at the beginning or in the midst of their working career. Work participation is very important for a person’s sense of self-respect, leading to financial security, social contacts and providing a feeling of usefulness and satisfaction. Despite a recent work history, many people with MS are unable to retain employment following diagnosis. The high prevalence of unemployment among people with MS and the large personal and societal costs involved underline the need to study factors associated with work participation and work functioning in MS. 

The MS@Work study aims to examine predictors of (changes in) employment status and work functioning in patients with relapsing-remitting MS and healthy controls over a period of three years. By taking into account a wide variety of physical, cognitive and psychological factors this study aims to reveal typical patterns leading to, or protecting against job loss. Identifying these patterns provides useful information about preventative factors for physicians, psychologists and vocational rehabilitation therapists.

As a follow-up project, our research group aims to use eHealth solutions to enable job retention in workers with multiple sclerosis.

Literature references

Clougherty, J.E., Souza, K., & Cullen, M.R. (2010). Work and its role in shaping the social gradient in health. Annals of the New York Academy of Sciences, 1186, 102-124. doi:10.1111/j.1749-6632.2009.05338.x

Gommer, A.M., & Poos, M.J.J.C. (2010). Cijfers multiple sclerose (prevalentie, incidentie en sterfte). Volksgezondheid Toekomst Verkenning, Nationaal Kompas Volksgezondheid, 3.22.

Krokavcova, M., Nagyova, I., Van Dijk, J.P., Rosenberger, J., Gavelova, M., Middel, B., . . . Groothoff, J.W. (2010). Self-rated health and employment status in patients with multiple sclerosis. Disabil Rehabil, 32(21), 1742-1748. doi:10.3109/09638281003734334

Roessler, R.T., & Rumrill, P.D., Jr. (2003). Multiple sclerosis and employment barriers: a systemic perspective on diagnosis and intervention. Work, 21(1), 17-23.

Sweetland, J., Howse, E., & Playford, E.D. (2012). A systematic review of research undertaken in vocational rehabilitation for people with multiple sclerosis. Disability and rehabilitation. doi:10.3109/09638288.2012.669019

Publications MS@Work study

•    van Der Hiele, K., Van Egmond, E., van Gorp, D.A.M. (2020). Werken met multiple sclerose. Quintesse, 1, 14-20. https://www.quintesse-online.nl/tijdschrift/editie/artikel/t/werken-met-multiple-sclerose

•    van Der Hiele, K., Van Egmond, E., Jongen, P., Van Der Klink, J., Beenakker, E., Van Eijk, J., . . . Visser, L. (2020). Empathy in multiple sclerosis––Correlates with cognitive, psychological and occupational functioning. Multiple Sclerosis and Related Disorders, 41, 102036. doi: 10.1016/j.msard.2020.102036

•    van Egmond, E.E.A., van Gorp, D.A., Jongen, P. J., Reneman, M.F., van der Klink, J.J.L., … van der Hiele, K. (2019). A Dutch validation study of the Multiple Sclerosis Work Difficulties Questionnaire in relapsing remitting multiple sclerosis. Disability and Rehabilitation, 1-10. doi: 10.1080/09638288.2019.1686072.

•    van Gorp, D.A.M., van der Hiele, K., Heerings, M.A.P., Jongen, P.J., van der Klink, J.J.L., … Middelkoop, H.A.M. (2019). Cognitive functioning and employment status in relapsing remitting multiple sclerosis: a 2-year longitudinal study. Neurological Sciences, 1-10. doi: 10.1007/s10072-019-03999-w. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848242/

•    van der Hiele, K., van Gorp, D. A., Heerings, M.A., Jongen, P. J., van der Klink, J.J.L., … Visser, L.H. (2019). Caregiver strain among life partners of individuals with relapsing-remitting multiple sclerosis. Multiple Sclerosis and Related Disorders, 31:5-11. doi: 10.1016/j.msard.2019.03.005. https://www.sciencedirect.com/science/article/pii/S2211034819301105?via%3Dihub

•    van Gorp, D.A., van der Hiele, K., Middelkoop, H.A.M. & Visser, L.H. (2019). The relation between cognitive functioning and work outcomes in patients with Multiple Sclerosis: a systematic literature review. Current Research in Neurology and Neurosurgery, 2(1), 011-029. https://www.somatopublications.com/the-relation-between-cognitive-functioning-and-work-outcomes-in-patients-with-multiple-sclerosis-a-systematic-literature-review.pdf

•    van Gorp, D. A., van der Klink, J., Abma, F., Heerings, M. A., van Lieshout, I., Jongen, P. J., . . . Van der Hiele, K. The capability set for work – correlates of sustainable employability in workers with Multiple Sclerosis (2018). Health and Quality of Life Outcomes, 16(1), 113. doi: 10.1186/s12955-018-0942. https://hqlo.biomedcentral.com/articles/10.1186/s12955-018-0942-7

•    van der Meide, H., van Gorp, D. van der Hiele, K., & Visser, L. (2017). "Always looking for a new balance": toward an understanding of what it takes to continue working while being diagnosed with relapsing-remitting multiple sclerosis. Disability and Rehabilitation, 1-8. doi:10.1080/09638288.2017.1342278.

•    van der Hiele, K., van Gorp, D., Benedict, R., Jongen, P. J., Arnoldus, E., Beenakker, E., . . . Visser, L. H. (2016). Coping strategies in relation to negative work events and accommodations in employed multiple sclerosis patients. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, 2055217316680638. doi:10.1177/2055217316680638. 

•    van der Hiele, K., van Gorp, D. A., Heerings, M. A., van Lieshout, I., Jongen, P. J., Reneman, M. F., . . . Visser, L.H. (2016). Factoren van invloed op arbeidsprestatie bij patiënten met multiple sclerose. Tijdschrift voor Neurologie & Neurochirurgie, 1 (117).

•    van der Hiele, K., van Gorp, D. A., Heerings, M. A., van Lieshout, I., Jongen, P. J., Reneman, M. F., . . . Group, M. S. W. S. (2015). The MS@Work study: a 3-year prospective observational study on factors involved with work participation in patients with relapsing-remitting Multiple Sclerosis. BMC Neurology, 15 (134). doi:10.1186/s12883-015-0375-4. 

•    van der Hiele, K., van Gorp, D., Ruimschotel, R., Kamminga, N., Visser, L., Middelkoop, H. (2015). Work participation and executive abilities in patients with relapsing-remitting multiple sclerosis. PLoS ONE; 10(6): e0129228. https://doi.org/10.1371/journal.pone.0129228

•    van der Hiele, K., Middelkoop, H.A., Ruimschotel, R.P., Kamminga, N.G.A., Visser, L.H. (2014). A pilot study on factors involved with work participation in the early stages of Multiple Sclerosis. PLoS ONE; 9(8): e105673. https://doi.org/10.1371/journal.pone.0105673

Handreikingen MS en werk
•    Alfrink, F., van Bakel, V., Bijleveld–Coene, T., Bol, Y., van Gorp, D., Hallie, G., … Wisgerhof-van Dijk, R.  (2017, October 25). Handreikingen MS en werk [Practical guidance MS and work]. Fit for work. https://www.fitforworknederland.nl/wp-content/uploads/2017/10/handreikingen_MS_en_werk_def_25okt2017.pdf

Blogs and interviews
•    Welke factoren zorgen ervoor dat mensen met MS kunnen blijven werken? Care4Contact, januari 2014 (Interview with K. van der Hiele)

•    van der Hiele, K. (2016) https://www.leidenpsychologyblog.nl/articles/having-a-chronic-disease-and-a-job-is-that-even-possible, maart 2016.

•    van der Meide, H. & Visser, L.H. Chronisch zieke krijgt van zijn baas weinig begrip. https://www.socialevraagstukken.nl/chronisch-zieke-krijgt-van-zijn-baas-weinig-begrip/, april 2016.

•    Misverstanden over werken met MS. https://www.etz.nl/Over-ETZ/Nieuws/2018/02/Misverstanden-over-werken-met-MS. Persbericht Roche, februari 2018 (Interview with L.H. Visser)

•    Werk als belangrijke waarde in je leven. MultipleS, oktober 2019 (Interview with K. van der Hiele)

Connection with other research

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