Universiteit Leiden

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Dissertation

Novel Protecting Group Strategies in the Synthesis of Oligosaccharides

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Author
Volbeda, A.G.
Date
31 May 2018
Links
Thesis in Leiden Repository

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups. New protecting group deprotection methods and protecting groups are developed. These novelties are applied in the synthesis of oligosaccharides which represent interesting biological targets. A solid phase approach is used to construct a library of oligorhamnans, employing a protecting group developed in this thesis. A fast deprotection method is employed to selectively remove fucntionalized benzyl ethers, which allows for the introduction of functional groups on a mannuronic acid molecule. Future synthesis campaigns are drafted combining the methods used in the previous chapters.

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