NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
- D.M. Shah
- 17 June 2014
- Thesis in Leiden Repository
The research presented in the thesis describes the development and implementation of solution based NMR methods that provide 3D structural information on the protein-small molecule complexes. These methods can be critical for structure based drug design and can be readily applied in the early stages of preclinical drug discovery and fragment based drug discovery.