Universiteit Leiden

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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

He, Y.
11 January 2023
Thesis in Leiden Repository

A fully automated, high-throughput, and high enrichment sample-preparation method, electroextraction, was developed. The metabolomics mechanism analysis of sarcopenia by using mouse models facilitate the understanding of metabolic processes underlying sarcopenia and can help to identify treatment options in the future.

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