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Composition and function of integrin adhesions

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

Zuidema, A.C.
20 October 2022
Thesis in Leiden Repository

This thesis provides an overview of the distinct types of integrin-containing cell adhesion complexes present in epithelial cells. By employing BioID we succesfully characterized the composition of focal adhesions, flat clathrin lattices, and hemidesmosomes. In addition, we investigated the role of different adhesion complexes in (cancer) cell adhesion, migration, polarity, and proliferation and in mechanotransduction.

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