Thijs Aartsma
Professor emeritus of Biophysics
- Name
- Prof.dr. T.J. Aartsma
- Telephone
- +31 71 527 5967
- aartsma@physics.leidenuniv.nl
- ORCID iD
- 0000-0001-5496-0240
PhD Candidate
Professor emeritus of Biophysics
- Science
- Leiden Instituut Onderzoek Natuurkunde
- LION - Biological & Soft Matter
- Apetri M.M., Harkes R., Subramanian V., Canters G.W., Schmidt T. & Aartsma T.J. (2016), Direct observation of α-synuclein amyloid aggregates in endocytic vesicles of neuroblastoma cells, PLOS ONE 11(4): e0153020.
- Pradhan B., Khatua S.K., Gupta A., Aartsma T.J., Canters G.W. & Orrit M.A.G.J. (2016), Gold-nanorod-enhanced fluorescence correlation spectroscopy of fluorophores with high quantum yield in lipid bilayers, Journal of Physical Chemistry C 120(45): 25996-26003.
- Mucibabic M., Apetri M.M., Canters G.W. & Aartsma T.J. (2016), The effect of fluorescent labeling on a-synuclein fibril morphology, Biochimica et Biophysica Acta 1864(10): 1419-1427.
- Kamran M., Friebe V.M., Delgado J.D., Aartsma T.J., Frese R.N. & Jones M.R. (2015), Demonstration of asymmetric electron conduction in pseudosymmetrical photosynthetic reaction centre proteins in an electrical circuit, Nature Communications 6: 6530.
- Jendrny M., Aartsma T.J. & Koehler R.C.T. (2014), Insights into the Excitonic States of Individual Chlorosomes from Chlorobaculum tepidum, Biophysical Journal 106: 1921-1927.
- Mathwig K., Aartsma T.J., Canters G.W. & Lemay S.G. (2014), Nanoscale Methods for Single-Molecule Electrochemistry, Annual Review of Analytical Chemistry 7: 383-404.
- Kamran M., Friebe V.M., Delgado J.D., Aartsma T.J., Frese R.N. & Jones M.R. (2014), Nature knows best: demonstration of asymmetric electron tunnelling in pseudosymmetrical reaction centres in an electrical circuit, Nature Communications 6: 6530.
- Gupta A., Aartsma T.J. & Canters G.W. (2014), One at a Time: Intramolecular Electron-Transfer Kinetics in Small Laccase Observed during Turnover, Journal of the American Chemical Society 136(7): 2707-2710.
- Kamran M., Delgado J.D., Friebe V., Aartsma T.J. & Frese R.N. (2014), Photosynthetic Protein Complexes as Bio-photovoltaic Building Blocks Retaining a High Internal Quantum Efficiency, Biomacromolecules 15(8): 2833-2838.
- Gupta A., Aartsma T.J. & Canters G.W. (2014), Single molecule studies of electron transfer between copper centers of small laccase from S. coelicolor, Journal of Biological Inorganic Chemistry 19(Supplement 1): S282.
- Tabares L.C., Gupta A., Aartsma T.J. & Canters G.W. (2014), Tracking Electrons in Biological Macromolecules: From Ensemble to Single Molecule, Molecules 19(8): 11660-11678.
- Strianese M., Zauner G., Tabares L.C., Tepper A.W.J.W., Martino F. de, Pellecchia C., Aartsma T.J. & Canters G.W. (2013), Bi-enzyme sensor for phenolic compounds with fluorescent read-out, Chemistry-a European Journal 19(44): 14977-14982.
- Jendrny M., Aartsma T.J. & Kohler J. (2013), Fluorescence excitation spectra from individual chlorosomes of the green sulfur bacterium Chlorobaculum tepidum, Journal of Physical Chemistry Letters 3: 3745-3750.
- Elmalk A.T., Salverda J.M., Tabares L.C., Canters G.W. & Aartsma T.J. (2012), Probing redox proteins on a gold surface by single molecule fluorescence spectroscopy, Journal of Chemical Physics 136: 235101.
- Gustiananda M., Andreoni A., Tabares L.C., Tepper W.J.W., Fortunato L., Aartsma T.J. & Canters G.W. (2012), Sensitive detection of histamine using fluorescently labeled oxido-reductases, Biosensors and Bioelectronics 31(1): 419-425.
- Tepper W.J.W., Aartsma T.J. & Canters G.W. (2011), Channeling of electrons within SLAC, the small laccase Streptomyces coelicolor, Faraday Discussions 148: 161-171.
- Hollander M.J., Magis J.G., Fuchsenberger P., Aartsma T.J., Jones M.R. & Frese R.N. (2011), Enhanced Photocurrent Generation by Photosynthetic Bacterial Reaction Centers through Molecular Relays, Light-Harvesting Complexes, and Direct Protein-Gold Interactions, LANGMUIR 27(16): 10282-10294.
- Tabares L.C., Kostrz D, Elmalk A.T., Andreoni A., Dennison C., Aartsma T.J. & Canters G.W. (2011), Fluorescence life time analyses of nitrite reductasefrom A.xylosoxidans at the single molecule level reveals enzyme mechanism, Chemistry-a European Journal 17(43): 12015-12019.
- Krzeminski L., Cronin S., Ndamba L.A., Canters G.W., Aartsma T.J., Evans S.D. & Jeuken L.J.C. (2011), Orientational Control over Nitrite Reductase on Modified Gold Electrode and its Effects on the Interfacial Electron Transfer, Journal of Physical Chemistry B 115(43): 12607-12614.
- Goldsmith R.H., Tabares L.C., Kostrz D., Dennison C., Aartsma T.J., Canters G.W. & Moerner W.E. (2011), Redox cycling and kinetic analyses of single molecules of solution-phase nitrite reductase, Proceedings of the National Academy of Sciences of the United States of America 108(42): 17269-17274.
- Gustiananda M., Andreoni A., Tabares L.C., Tepper W.J.W., Fortunato L., Aartsma T.J. & Canters G.W. (2011), Sensitive detection of histamine using fluorescently labeled oxido-reductases, Biosensors and Bioelectronics 31(1): 419-425.
- Krzeminski L., Ndamba L. A., Canters G.W., Aartsma T.J., Evans S.D. & Jeuken L.J.C. (2011), Spectroelectrochemical Investigation of Intramolecular and Interfacial Electron-Transfer Rates Reveals Differences Between Nitrite Reductase at Rest and During Turnover, Journal of the American Chemical Society 133(38): 15085-15093.
- Magis J.G., Olsen J.D., Reynolds N.P., Legget G.J., Hunter C.N., Aartsma T.J. & Frese R.N. (2011), Use of Engineered Unique Cysteine Residues to Facilitate Oriented Coupling of Proteins Directly to a Gold Substrate, Photochemistry and Photobiology 87(5): 1050-1057.
- Salverda J.M., Patil A.V., Kuznetsova S., Zauner G., Akkilic N., Canters G.W., Davis J.J., Heering H.A. & Aartsma T.J. (2010), Fluorescent voltammetry of immobilized azurin: a direct observation of thermodynamic and kinetic heterogeneity, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH 49(33): 5776-5779.
- Davis J.J., Peters B., Xi W., Appel J., Kros A., Aartsma T.J., Stan R.C. & Canters G.W. (2010), Large amplitude conductance gating in a wired redox molecule, Journal of Physical Chemistry Letters 1(10): 1541-1546.
- Magis J.G., Hollander M.J., Onderwaater W.G., Olsen J.D., Hunter C.N., Aartsma T.J. & Frese R.N. (2010), Light harvesting, energy transfer and electron cycling of a native photosynthetic membrane adsorbed onto a gold surface, BBA - Biomembranes 1798(3): 637-645.
- Strianese M., Zauner G., Tepper A., Bubacco L., Breukink E., Aartsma T.J., Canters G.W. & Tabares L.C. (2009), A protein-based oxygen biosensor for high-throughput monitoring of cell growth and cell viability, Analytical Biochemistry 385(2): 242-248.
- Liu L.-N., Elmalk A.T., Aartsma T.J., Thomas J.-C., Lamers G.E.M., Zhou B.-C. & Zhang Y. (2008), Light-induced energetic decoupling as a mechanism for phycobilisome-related energy dissipation in red algae: A single molecule study, PLoS ONE 3(9): e3134.
- Kuznetsova S.A., Zauner G., Aartsma T.J., Engelkamp H., Hatzakis N., Rowan A., Nolter R.J.M., Christianen P.C.M. & Canters G.W. (2008), The Enzyme Mechanism of Nitrite Reductase Studied at Single-Molecule Level, Proceedings of the National Academy of Sciences of the United States of America 105(9): 3250-3255.
- Zauner G., Strianese M., Bubacco L., Aartsma T.J., Tepper W.J.W. & Canters G.W. (2008), Type-3 Copper Proteins as Biocompatible and reusable Oxygen Sensors, Inorganica Chimica Acta 361(4): 1116-1121.
- Ruijter W.P.F. de, Segura J.-M., Cogdell R., Gardiner A.T., Oellerich S. & Aartsma T.J. (2007), Fluorescence emission spectroscopy of individual LH2 and LH3 complexes, Chemical Physics 341(1-3): 320-325.
- Aartsma T.J. & Köhler J. (2007), Optical spectroscopy of individual Light-Harvesting complexes. In: Biophysical Techniques in Photosynthesis II. The Netherlands: Springer. 241-266.
- Frese R.N., Pàmies J.C., Olsen J.D., Bahatyrova S., Weij-de Wit C.D. van der, Aartsma T.J., Otto C., Hunter C.N., Frenkel D. & Grondelle R. van (2007), Protein shape and crowding drive domain formation and curvature in biological membranes, Biophysical Journal 94(2): 640-647.
- Ana A.A., Liu L.-N., Aartsma T.J., Zhang Y. & Boekema E.J. (2007), Structure and organization of phycobilisomes on membranes of the red Algra Porphyridium cruentum, Photosynthesis Research 95(2-3): 169-174.
- Zauner G., Lonardi E., Bubaco L., Aartsma T.J., Canter G.W. & Tepper W.J.W. (2007), Tryptophan-to-dye fluorescence energy transfer applied to oxygen sensing by using type-3 copper proteins, Chemistry-a European Journal 13(25): 7085-7090.
- Kuznetsova S., Zauner G., Schmauder R., Mayboroda O.A., Deelder A.M., Aartsma T.J. & Canters G.W. (2006), A Förster-resonance-energy-transfer based method for fluorescence detection of the protein redox state, Analytical Biochemistry 350(1): 52-60.
- Davis J.J., Burgess H., Zauner G., Kuznetsova S.A., Salverda J.M., Aartsma T.J. & Canters G.W. (2006), Monitoring interfacial bioelectrochemistry using a FRET Switch, Journal of Physical Chemistry B 110(41): 20649-20654.
- Ketelaars M., Segura J.-M., Oellerich S., Ruijter W.P.F. de, Magis G., Aartsma T.J., Matsushita M., Schmidt J., Cogdell R. & Köhler R.D. (2006), Probing the Electronic Structure and Conformational Flexibility of Individual Light-Harvesting 3 Complexes by Optical Single-Molecule Spectroscopy, Journal of Physical Chemistry B 110(37): 18710-18717.
- Köhler J. & Aartsma T.J. (2006), Single-molecule spectroscopy of pigment-protein complexes from purple bacteria. In: Grimm B., Porra R.J., Scheer H. (Eds.) Chlorophylls and Bacteriochlorophylls. Advances in Photosynthesis and Respiration no. 25 Dordrecht: Springer. 309-321.
- Miqyass M., Gorkom H.J. van, Yocum E.F., Aartsma T.J., Matsushita M., Schmidt J., Cogdell R. & Koehler J. (2006), The PSII calcium site revisited, Photosynthesis Research 92(3): 275-287.
- Frigaard N.-U., Li H., Martinsson P, Das S.K., Frank H.A., Aartsma T.J. & Bryant D.A. (2005), Isolation and characterization of carotenosomes from a bacteriochlorophyll c-less mutant of Chlorobium tepidum, Photosynthesis Research 86(1): 101-111.
- Schmauder R., Alagaratnam S., Chan C., Schmidt Th., Canters G.W. & Aartsma T.J. (2005), Sensitive detection of the redox state of copper proteins using fluorescence, Journal of Biological Inorganic Chemistry 10(6): 683-687.
- Schmauder R., Librizzi R., Canters G.W., Schmidt Th. & Aartsma T.J. (2005), The oxidation state of a protein observed molecule-by-molecule, CHEMPHYSCHEM 6(7): 1381-1386.
- Hofmann C., Aartsma T.J. & Köhler J. (2004), Energetic disorder and the B850-exciton states of individual light-harvesting 2 complexes from Rhodopseudomonas acidophila, Chemical Physics Letters 395(4-6): 373-378.
- Ruijter W.P.F. de, Oellerich S., Segura J.-M., Lawless A.M., Papiz M. & Aartsma T.J. (2004), Observation of the energy-level structure of the low-light adapted B800 LH4 complex by single-molecule spectroscopy, Biophysical Journal 87(5): 3413-3420.
- Gradinaru C.C., Martinson P., Aartsma T.J. & Schmidt Th. (2004), Simultaneous atomic-force and two-photon fluorescence imaging of biological specimens in vivo, Ultramicroscopy 99(4): 235-245.
- Hofmann C., Aartsma T.J., Michel H. & Köhler J. (2004), Spectral dynamics in the B800 band of LH2 from Rhodospirillum molischianum: a single molecule study, New Journal of Physics 6(8): 008.
- Stamouli A., Frenken J.W.M., Oosterkamp T.H., Cogdel T.J. & Aartsma T.J. (2004), The electron conduction of photosynthetic protein complexes embedded in a membrane, FEBS Letters 560(1-3): 109-114.
- Hofmann C., Aartsma T.J., Michel H. & Köhler J. (2003), Direct observation of tiers in the energy landscape of a chromoprotein: a single-molecule study, Proceedings of the National Academy of Sciences of the United States of America 100(26): 15534-15538.
- Hofmann C., Ketelaars M., Matsushita M., Michel E., Aartsma T.J. & Köhler J. (2003), Single-molecule study of the electronic couplings in a circular array of molecules: Light-Harvesting-2 complex from Rhodospirillum molischianum, Physical Review Letters 90(1): 013004.
- Shkuropatov A.Ya., Neerken S., Permentier H.P., Wijn R. de, Schmidt S., Shuvalov V.A., Aartsma T.J., Gast P. & Hoff A.J. (2003), The effect of exchange of bacteriopheophytin a with plant pheophytin a on charge separation in Y(M210)W mutant reaction centers of Rhodobacter sphaeroides at low temperatures, Biochimica et Biophysica Acta 1557: 1-12.
- Stamouli A., Kafi S.T., Klein D.C.G., Oosterkamp T.H., Frenken J.W.M. & Aartsma T.J. (2003), The ring structure and organization of light harvesting 2 complexes in a reconstituted lipid bilayer, resolved by atomic force microscopy, Biophysical Journal 84: 2483-2494.
- Prokhorenko V., Holzwarth A.R., Nowak F.R. & Aartsma T.J. (2002), Growing-in of optical coherence in the FMO antenna complexes, Journal of Physical Chemistry B 106(38): 9923-9933.
- Oellerich S., Ketelaars M., Segura J.-M., Margis G., Ruijter W.P.F. de, Koehler J., Schmidt J. & Aartsma T.J. (2002), Individual LH3 (B800-820) light-harvesting com plexes studied by optical single-molecule spectroscopy, Single Molecules 3(5-6): 319-320.
- Gast P., Gorkom H.J. van, Aartsma T.J. & Schmidt Th. (2002), Obituary Arnold Hoff, Spectrochimica Acta Part A : Molecular and Biomolecular Spectroscopy 58(10): 2069-2070.
- Hoff A.J. & Aartsma T.J. (2002), Obituary Jan Amesz, Photosynthesis Research 71(1-2): 1-4.
- Miller M., Aartsma T.J. & Blankenship R.E. (2002), Special issue in honour of Jan Amesz: Green and heliobacteria - Introduction, Photosynthesis Research 71(1-2): VII-VII.
- Wendling M., Przyalgowski M.A., Gülen D., Vulto S.I.E., Aartsma T.J., Grondelle R. van & Amerongen H. van (2002), The quantitative relationship between structure and polarized spectroscopy in the FMO complex of Prosthecochloris aestuarii: refining experiments and simulations, Photosynthesis Research 71(1-2): 99-123.
- Steensgaard D.B., Walree C.A. van, Permentier H.P., Baneras L., Borrego C.M., Garcia-Gil J., Aartsma T.J., Amesz J. & Holzwarth A.R. (2000), Fast energy transfer between BChl {it d} and BChl c in chlorosomes of the green sulfur bacterium Chlorobium limicola, Biochimica et Biophysica Acta 1457(1-2): 71-80.
- Neerken S., Aartsma T.J. & Amesz J. (2000), Pathways of energy transformation in antenna reaction center complexes of Heliobacillus mobilis, Biochemistry 39(12): 3297-3303.
- Oijen A.M. van, Ketelaars M., Kohler J., Aartsma T.J. & Schmidt J. (2000), Spectroscopy of individual light-harvesting 2 complexes of Rhodopseudomonas acidophila: Diagonal disorder, intercomplex heterogeneity, spectral diffusion, and energy transfer in the B800 band, Biophysical Journal 78: 1570-1577.
- Neerken S., Schmidt K.A., Aartsma T.J. & Amesz J. (1999), Dynamics of energy conversion in reaction center core complexes of the green sulfur bacterium Prosthecochloris aestuarii at low temperature, Biochemistry 38(40): 13216-13222.
- Vulto S.I.E., Kennis J.T.M., Streltsov A.M., Amesz J. & Aartsma T.J. (1999), Energy relaxation within the B850 absorption band of the isolated light-harvesting complex LH2 from Rhodopseudomonas acidophila at low temperature, Journal of Physical Chemistry B 103(5): 878-883.
- Vulto S.I.E., Kennis J.T.M., Streltsov A.M., Amesz J. & Aartsma T.J. (1999), Energy relaxation within the B850 absorption band of the LH2 complex from Rhodopseudomonas acidophila at 7 K. In: Garab G. (Ed.) Photosynthesis: Mechanisms and Effects. Dordrecht, The Netherlands: Kluwer Academic Publishers. 53-60.
- Oijen A.M. van, Ketelaars M., Kohler J., Aartsma T.J. & Schmidt J. (1999), Spectroscopy of individual LH2 complexes of Rhodopseudomonas acidophila: localized excitations in the B800 band, Chemical Physics 247(1): 53-60.
- Oijen A.M. van, Ketelaars M., Köhler J., Aartsma T.J. & Schmidt J. (1999), Unraveling the electronic structure of individual photosynthetic pigment-protein complexes, SCIENCE 285: 400-402.
- Nowak F.R., Louwe R.J.W., Schmidt K.A., Permentier H.P. & Aartsma T.J. (1998), Accumulated photon echo studies on 3FMO-RCC and RCC from Prosthecochloris aestuarii. In: Garab G. (Ed.) Photosynthesis: Mechanisms and Effects, Vol. I. Dordrecht, The Netherlands: Kluwer Academic Publishers. 185-188.
- Streltsov A.M., Vulto S.I.E., Shkuropatov A.Ya., Hoff A.J., Aartsma T.J. & Shuvalov V.A. (1998), BA and BB absorbance perturbations induced by coherent nuclear motions in reaction centers from Rhodobacter sphaeroides upon 30-fs excitation of the primary donor, Journal of Physical Chemistry B 102(37): 7293-7298.
- Streltsov A.M., Vulto S.I.E., Shkuropatov A.Ya., Hoff A.J., Aartsma T.J. & Shuvalov V.A. (1998), Coherent nuclear motions in reaction centers from Rhodobacter Sphaeroides upon 30-femtosecond excitation. In: Garab G. (Ed.) Photosynthesis: Mechanisms and Effects, Vol. II. Dordrecht, The Netherlands: Kluwer Academic Publishers. 679-682.
- Schmidt K.A., Permentier H.P., de Wijn R., Neerken S., Franken E.M., Francke C., Hager-Braun C., Aartsma T.J. & Amesz J. (1998), Electron transfer in reaction centers from green sulfur bacteria. In: Garab G. (Ed.) Photosynthesis: Machanisms and Effects, Vol. I. Dordrecht, The Netherlands: Kluwer Academic Publishers. 543-546.
- Neerken S., Permentier H.P., Francke C., Aartsma T.J. & Amesz J. (1998), Excited states and trapping in reaction center complexes of the green sulfur bacterium Prosthecochloris aestuarii, Biochemistry 37: 10792-10797.
- Vulto S.I.E., Neerken S., Louwe R.J.W., Baat M.A. de, Amesz J. & Aartsma T.J. (1998), Excited-state structure and dynamics in FMO antenna complexes from photosynthetic green sulfur bacteria, Journal of Physical Chemistry B 102(51): 10630-10635.
- Vulto S.I.E., Baat M.A. de, Louwe R.J.W., Permentier H.P., Neef T., Miller M., Amerongen H. van & Aartsma T.J. (1998), Exciton simulations of optical spectra of the FMO complex from the green sulfur bacterium Chlorobium tepidum at 6 K, Journal of Physical Chemistry B 102(47): 9577-9582.
- Neerken S., Permentier H.P., Aschenbrucker J., Ma Y.Z., Francke C., Schmidt K.A., Gillbro T., Aartsma T.J. & Amesz J. (1998), Relaxation and trapping in reaction centers of the green sulfur bacterium Prosthecochloris aestuarii. In: Garab G. (Ed.) Photosynthesis: Mechanisms and Effects, Vol. I. Dordrecht, The Netherlands: Kluwer Academic Publishers. 539-542.
- Boer A.L. de, Neerken S., Permentier H.P., Vijgenboom E., Gast P., Aartsma T.J. & Hoff A.J. (1998), Spectroscopic characterization of two new reaction center mutants of the photosynthetic bacterium Rhodobacter sphaeroides. In: Garab G. (Ed.) Photosynthesis: Mechanisms and Effects, Vol. II. Dordrecht, The Netherlands: Kluwer Academic Publishers. 747-750.
- Oijen A.M. van, Ketelaars M., Kohler J., Aartsma T.J. & Schmidt J. (1998), Spectroscopy of single light-harvesting complexes from purple photosynthetic bacteria at 1.2 K, Journal of Physical Chemistry B 102: 9363-9366.
- Nowak F.R., Kennis J.T.M., Franken E.M., Shkuropatov A.Ya., Yakovlev A., Gast P., Hoff A.J., Aartsma T.J. & Shuvalov V.A. (1998), The energy level of P^+BA- in plant pheophytin-exchanged bacterial reaction centers probed by the temperature dependence of delayed fluorescence. In: Garab G. (Ed.) Photosynthesis: Mechanisms and Effects, Vol. II. Dordrecht, The Netherlands: Kluwer Academic Publishers. 783-786.
- Louwe R.J.W., Aartsma T.J., Gast P., Hulsebosch R.J., Nan H.M., Vrieze J. & Hoff A.J. (1998), The triplet state of the FMO complex of the green sulfur bacterium Prosthecochloris aestuarii studied with single-crystal EPR, Biochimica et Biophysica Acta (BBA) - Bioenergetics 1365(3): 373-384.
- Vulto S.I.E., Neerken S., Baat M.A. de, Louwe R.J.W., Miller M., Amesz J. & Aartsma T.J. (1998), Time-resolved spectra of the FMO-complex of green sulfur bacateria: simulations and experiments. In: Garab G. (Ed.) Photosynthesis: Mechanisms and Effects, Vol. I. Dordrecht: Kluwer Academic Publishers. 189-192.
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