Nora Brüchle
PhD candidate
- Name
- N.C. Brüchle MSc
- Telephone
- +31 71 527 4363
- n.c.bruchle@biology.leidenuniv.nl
.
Supervisor(s)
PhD candidate
- Science
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Al Ayed U.K., Ballantine R.D., Hoekstra M., Bann S.J., Wesseling C.M.J., Bakker A.T., Zhong Z., Li Y.X., Brüchle N.C., Stelt M. van der, Cochrane S.A. & Martin N.I. (2022), Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy, Chemical Science 13(12): 3563-3570.
- Haren M.J. van, Tehrani K.H.M.E., Kotsogianni Teftsoglou A.I., Wade N., Brüchle N.C., Mashayekhi V. & Martin N.I. (2021), Cephalosporin prodrug inhibitors overcome metallo‐β‐lactamase driven antibiotic resistance, Chemistry: a European Journal 27(11): 3806-3811.
- Wade N., Tehrani K.H.M.E., Brüchle N.C., Haren M.J. van, Mashayekhi Vi. & Martin N.I. (2021), Mechanistic investigations of metallo‐β‐lactamase inhibitors: strong zinc binding Is not required for potent enzyme inhibition, ChemMedChem 16(10): 1651-1659.
- Tehrani K.H.M.E., Wade N., Mashayekhi V., Brüchle N.C., Jespers W., Voskuil K., Pesce D., Haren. M.J. van, Westen G.J.P. van & Martin N.I. (2021), Novel cephalosporin conjugates display potent and selective inhibition of imipenemase-type metallo-β-lactamases, Journal of Medicinal Chemistry 64(13): 9141-9151.
- Tehrani K.H.M.E., Fu H., Brüchle N.C., Mashayekhi V., Prats Luján A., Haren M.J. van, Poelarends G.J. & Martin N.I. (2020), Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N′-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1, Chemical Communications 56(20): 3047-3049.
- Tehrani K.H.M.E., Brüchle N.C., Wade N., Mashayekhi V., Pesce D., Haren M.J. van & Martin N.I. (2020), Small molecule carboxylates inhibit metallo-β-lactamases and resensitize carbapenem-resistant bacteria to meropenem, ACS Infectious Diseases 6(6): 1366-1371.