Ned Buijs
Projectmanager
- Name
- Dr. N.P. Buijs Ph.D.
- Telephone
- +31 71 527 4782
- n.p.buijs@lic.leidenuniv.nl
- ORCID iD
- 0000-0001-7613-4951
Brief biography
Ned graduated from The University of Glasgow with a 1st class honours MSci degree in chemistry. During his master’s Ned worked under the supervision of Andrew Sutherland on synthesising novel fluorescent benzotriazole derived α-amino acids for use in biological imaging. In 2018 Ned was awarded the prestigious Salters’ Graduate Award by the Salters’ Institute in London after being nominated by the School of Chemistry at the University of Glasgow. Further research experience includes a 12-month placement in 2017 at Procter & Gamble working in an R&D role on detergent technologies. Ned’s contributions to a new product at P&G yielded 6 patents on which he is a named co-inventor.
Projectmanager
- Faculty of Science
- Leiden Institute of Chemistry
- LIC/Diensten
- LIC/D/Management & Secretariats
- Machushynets V., Al Ayed K., Terlouw R., Du C., Buijs P., Willemse J., Elsayed S., Schill J., Trebosc V.: Pieren M., Alexander F.M., Cochrane S.A., Liles M.R., Medema M.H., Martin N.I. & Wezel G.P. van (2024), Discovery and derivatization of tridecaptin antibiotics with altered host specificity and enhanced bioactivity, ACS Chemical Biology 19(5): 1106-1115.
- Buijs N.P., Vlaming H.C., Kotsogianni A.I, Willemse J.J., Duan Y., Alexander F.M., Cochrane S.A., Schneider T. & Martin N.I. (2024), A classic antibiotic reimagined: rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens, Proceedings of the National Academy of Sciences 121(29): e2315310121.
- Buijs N.P. (20 December 2023), Next generation bacitracin: reimagining a classic antibiotic (Dissertatie. Institute of Biology Leiden (IBL), Faculty of Science, Leiden University). Supervisor(s) and Co-supervisor(s): Martin N.I., Haren M.J. van.
- Wood T.M., Zeronian M.R., Buijs N.P., Bertheussen K., Abedian H.K., Johnson A.V., Pearce N.M., Lutz M., Kemmink J., Seirsma T., Hamoen L.W., Janssen B.J.C. & Martin N.I. (2022), Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures, Chemical Science 13(10): 2985-2991.
- Buijs N., Vlaming H.C., Haren M.J. van & Martin N.I. (2022), Synthetic studies with bacitracin A and preparation of analogues containing alternative zinc binding groups, ChemBioChem 23(24): e202200547.
- Gao Y., Haren M.J., Buijs N., Innocent I., Zhang Y., Sartini D., Campagna R., Emanuelli M., Parsons R.B., Jespers W., Gutiérrez-de-Terán H., Westen G.J.P. van & Martin N.I. (2021), Potent inhibition of nicotinamide N-Methyltransferase by alkene-linked bisubstrate mimics bearing electron deficient aromatics, Journal of Medicinal Chemistry 64(17): 12938-12963.
- Haren M.J. van, Zhang Y., Thijssen V., Buijs N.P., Gao Y., Mateuszuk L., Fedak F.A., Kij A., Campagna R., Sartini D., Emanuelli M., Chlopicki S., Jongkees S.A.K. & Martin N.I. (2021), Macrocyclic peptides as allosteric inhibitors of nicotinamide n-methyltransferase (NNMT), RSC Chemical Biology 2(5): 1546-1555.
- Haren M.J. van, Gao Y., Buijs N., Campagna R., Sartini D., Emanuelli M., Mateuszuk L., Kij A., Chlopicki S., Martinez de Castilla P.E., Schiffelers R. & Martin N.I. (2021), Esterase-sensitive prodrugs of a potent bisubstrate inhibitor of Nicotinamide N-Methyltransferase (NNMT) display cellular activity, Biomolecules 11(9): 1357.