Meindert Lamers
Co-director NeCEN & Associate professor (LUMC)
- Name
- Prof.dr. M.H. Lamers
- Telephone
- 071 5272727
- m.h.lamers@biology.leidenuniv.nl
- ORCID iD
- null
Meindert H. Lamers is co-director of the Netherlands Center for Electron Nanoscopy (NeCEN) at the Faculty of Science and head of the section Light and Electron Microscopy at the Leiden University Medical Center (LUMC). His research group at the LUMC studies molecular mechanisms of DNA replication and DNA repair.
More information
For details on Meindert Lamers' research, please visit the webpage of Lamer's lab.
Co-director NeCEN & Associate professor (LUMC)
- Faculty of Science
- Institute of Biology Leiden
- IBL general
Professor Cell and Chemical Biology, in specific Structural Biology
- Faculteit Geneeskunde
- Divisie 4
- Cel en Chemische biologie
Contact
- Ren M.R., Li D., Addison H., Noteborn W.E.M., Andeweg E.H., Glatter T., Winde J.H. de, Rebelein J.G., Lamers M.H. & Schada von Borzyskowski L. (2025), NAD-dependent dehydrogenases enable efficient growth of Paracoccus denitrificans on the PET monomer ethylene glycol, Nature Communications 16: 5845.
- Fernow, J.; Olliver, M.; Couet, W.; Lagrange, S.; Lamers, M.H.; Olesen, O.F.; Orrling, K.; Pieren, M.; Sloan, D.J.; Vaquero, J.J.; Miles, T.J. & Karlen, A. (2025), The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships, Nature Reviews Drug Discovery 24(1): 1-2.
- Santos, J.A.; Timinskas, K.; Ramudzuli, A.A.; Lamers, M.H.; Venclovas, C.; Warner, D.F. & Gessner, S.J. (2025), The RecA-NT homology motif in ImuB mediates the interaction with ImuA0, which is essential for DNA damage-induced mutagenesis, Journal of Biological Chemistry 301(2).
- Lippai, Z.; Péterfia, B.; Papp, G.; Dezso, K.; Bedics, G.; Pápai, Z.; Lamers, M.H.; Kuin, R.C.M.; Szuhai, K. & Sápi, Z. (2024), A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas, European Journal of Cancer 202.
- Kemps, P.G.; Baelde, H.J.; Vorderman, R.H.P.; Stelloo, E.; Swennenhuis, J.F.; Szuhai, K.; Lamers, M.H.; Kenkhuis, B.; Al-Hussaini, M.; Briaire-de Bruijn, I.H.; Lam, S.W.; Bovée, J.V.M.G.; Cleven, A.H.G.; Verdijk, R.M.; Noesel, C.J.M.; Dijk, M.R.; Scheijde-Vermeulen, M.A.; Bruggink, A.H.; Laar, J.A.M.; Vries, A.C.H.; Tissing, W.J.E.; Bos, C. van den; Deimling, A. von; Wezel, T. van; Halteren, A.G.S. & Hogendoorn, P.C.W. (2024), Recurrent CLTC::SYK fusions and CSF1R mutations in juvenile xanthogranuloma of soft tissue, Blood 144(23): 2439-2455.
- Botto, M.M.; Borsellini, A. & Lamers, M.H. (2023), A four-point molecular handover during Okazaki maturation, Nature Structural and Molecular Biology 30(10): 1505-+.
- Gessner, S.; Martin, Z.A.M.; Reiche, M.A.; Santos, J.A.; Dinkele, R.; Ramudzuli, A.; Dhar, N.; Wet, T.J. de; Anoosheh, S.; Lang, D.M.; Aaron, J.; Chew, T.L.; Herrmann, J.; Müller, R.; McKinney, J.D.; Woodgate, R.; Mizrahi, V.; Venclovas, C.; Lamers, M.H. & Warner, D.F. (2023), Investigating the composition and recruitment of the mycobacterial ImuA'-ImuB-DnaE2 mutasome, eLife 12.
- Botto, M.M.; Murthy, S. & Lamers, M.H. (2023), High-throughput exonuclease assay based on the fluorescent base Analogue 2-aminopurine, ACS Omega 8(9).
- Chengalroyen, M.D.; Mason, M.K.; Borsellini, A.; Tassoni, R.; Abrahams, G.L.; Lynch, S.; Ahn, Y.M.; Ambler, J.; Young, K.; Crowley, B.M.; Olsen, D.B.; Warner, D.F.; Barry, C.E.; Boshoff, H.I.M.; Lamers, M.H. & Mizrahi, V. (2022), DNA-dependent binding of nargenicin to DnaE1 inhibits replication in Mycobacterium tuberculosis, ACS Infectious Diseases 8(3): 612-625.
- Borsellini, A.; Kunetsky, V.; Friedhoff, P. & Lamers, M.H. (2022), Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair, Nature Structural and Molecular Biology 29(1): 59-+.
- Borsellini, A.; Lebbink, J.H.G. & Lamers, M.H. (2022), MutL binds to 3 ' resected DNA ends and blocks DNA polymerase access, Nucleic Acids Research 50(11): 6224-6234.
- Xiao, X.S.; Willemse, J.; Voskamp, P.; Li, X.M.; Prota, A.E.; Lamers, M.; Pannu, N.; Abrahams, J.P. & Wezel, G.P. van (2021), Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces, Open Biology 11(2).
- Fernandez-Leiro, R.; Bhairosing-Kok, D.; Kunetsky, V.; Laffeber, C.; Winterwerp, H.H.; Groothuizen, F.; Fish, A.; Lebbink, J.H.G.; Friedhoff, P.; Sixma, T.K. & Lamers, M.H. (2021), The selection process of licensing a DNA mismatch for repair, Nature Structural and Molecular Biology 28(4): 373-+.
- Singh, J.K.; Smith, R.; Rother, M.B.; Groot, A.J.L. de; Wiegant, W.W.; Vreeken, K.; D'Augustin, O.; Kim, R.Q.; Qian, H.B.; Krawczyk, P.M.; Gonzalez-Prieto, R.; Vertegaal, A.C.O.; Lamers, M.; Huet, S. & Attikum, H. van (2021), Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining, Nature Communications 12(1).
- Dodd, T.; Botto, M.; Paul, F.; Fernandez-Leiro, R.; Lamers, M.H. & Ivanov, I. (2020), Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path, Nature Communications 11(1).
- Santos, J.A. & Lamers, M.H. (2020), Novel antibiotics targeting bacterial replicative DNA polymerases, Antibiotics 9(11).
- Gahlon, H.L.; Walker, A.R.; Cisneros, G.A.; Lamers, M.H. & Rueda, D.S. (2018), Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant, Physical Chemistry Chemical Physics 20(42): 26892-26902.
- Lamers, M.; Berlin, I. & Neefjes, J. (2018), Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck, Current Biology 28(2): R83-R86.
- Lamers, M.H.; Gerogijevic, D.; Lebbink, J.H.; Winterwerp, H.H.K.; Agianian, B.; Wind, N. de & Sixma, T.K. (2004), ATP increases the affinity between MutS ATPase domains - Implications for atp hydrolysis and conformational changes, Journal of Biological Chemistry 279(42).
- Lamers, M.H.; Perrakis, A.; Enzlin, J.H.; Winterwerp, H.H.K.; Wind, N. de & Sixma, T.K. (2000), The crystal structure of DNA mismatch repair protein MutS binding to a G center dot T mismatch, Nature 407(6805).