Karol Al Ayed
PhD candidate / Guest
- Name
- Dr. U.K. Al Ayed
- Telephone
- +31 71 527 2727
- u.k.al.ayed@biology.leidenuniv.nl
- ORCID iD
- 0000-0003-1383-762X
PhD candidate / Guest
- Faculty of Science
- Institute of Biology Leiden
- IBL Biotechnology & Health
- Al Ayed U.K. (23 January 2024), Next generation lipopeptide antibiotics (Dissertatie. Institute of Biology Leiden (IBL), Faculty of Science, Leiden University). Supervisor(s) and Co-supervisor(s): Martin N.I., Innocenti P.
- Ballantine R.D., Al Ayed U.K., Bann S.J., Hoekstra M., Martin N.I. & Cochrane S.A. (2023), Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity, Journal of Medicinal Chemistry 66(8): 6002-6009.
- Al Ayed U.K., Zamarbide Losada S.D., Machushynets N.V., Terlouw B., Elsayed S.S.M.A., Shill J., Trebos V., Pieren M., Medema M.H., Wezel G.P. van & Martin N.I. (2023), Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability, ACS infectious diseases 9(4): 739-748.
- Al Ayed U.K., Ballantine R.D., Hoekstra M., Bann S.J., Wesseling C.M.J., Bakker A.T., Zhong Z., Li Y.X., Brüchle N.C., Stelt M. van der, Cochrane S.A. & Martin N.I. (2022), Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and in vivo efficacy, Chemical Science 13(12): 3563-3570.
- Ballantine R.D., Al Ayed U.K., Bann S.J., Hoekstra M., Martin N.I. & Cochrane S.A. (2022), Synthesis and structure–activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine, RSC Medicinal Chemistry 13: 1640-1643.
- Zhou J., Mock E.D., Al Ayed K., Di X., Kantae V., Burggraaff L., Stevens A.F., Martella A., Mohr F., Jiang M., Wel T. van der, Wendel T.J., Ofman T.P., Tran Y., Koster N. de, Westen G.J.P. van, Hankemeier T. & Stelt M. van der (2020), Structure-Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family, Journal of Medicinal Chemistry 63(17): 9340-9359.
- Zhou J., Mock E.D., Martella A., Kantae V., Di X., Burggraaff L., Baggelaar M.P., Al-Ayed K., Bakker A., Florea B.I., Grimm S.H., Dulk H. den, Li C.T., Mulder L., Overkleeft H.S., Westen G.J.P. van, Hankemeier T. & Stelt M. van der (2019), Activity-based protein profiling identifies α-ketoamides as inhibitors for Phospholipase A2 Group XVI, ACS Chemical Biology 14(2): 164-169.
No relevant ancillary activities