John van Noort
Professor Biofysica
- Name
- Prof.dr.ir. S.J.T. van Noort
- Telephone
- +31 71 527 5980
- noort@physics.leidenuniv.nl
- ORCID iD
- 0000-0002-9094-5598
More information about John van Noort
PhD Candidates
News
-
Can we live longer? Leiden physicist makes discovery in protective layer in genes -
LION in lockdown -
Two-photon microscope captures plant cells -
Bending DNA costs less energy than assumed -
Our genome captured in numbers -
NWO ECHO grant for research on fickle RNA production -
Biophysicists unravel exact folding of a single gene -
John van Noort appointed Professor in Biophysics -
New funding for advanced microscopy using gold nanorods
-
Folded DNA unravelled -
DNA folded in compliant helix
In the media
Former PhD candidates
Professor Biofysica
- Science
- Leiden Instituut Onderzoek Natuurkunde
- LION - Biological & Soft Matter
- Egorova E.A., Arias Alpizar G., Vlieg R.C., Gooris G.S., Bouwstra J.A., Noort S.J.T. van, Kros A. & Boyle A.L. (2022), Coating gold nanorods with self-assembling peptide amphiphiles promotes stability and facilitates in vivo two-photon imaging, Journal of Materials Chemistry. B 10: 1612-1622.
- Vlieg R.C. & Noort S.J.T. van (2022), Multiplexed two-photon excitation spectroscopy of single gold nanorods, The Journal of Chemical Physics 156: 094201.
- Radoslaw J., Jong B. de, Hage P. van, Rhiemus M., Steenis F. van, Noort S.J.T. van, Schmidt T. & Schaaf M.J.M (2022), Analysis of the H-Ras mobility pattern in vivo shows cellular heterogeneity inside epidermal tissue, Disease Models and Mechanisms 15(2): dmm049099.
- Brouwer T.B., Pham L., Kaczmarczyk A.P., Voogd W. de, Botto M., Vizjak P., Mueller-Planitz F. & Noort S.J.T. van (2021), A critical role for linker DNA in higher-order folding of chromatin fibers, Nucleic Acids Research 49(5): 2537-2551.
- Erkelens A.M., Henneman B., Brouwer T.B., Kuijntjes G.A.J.T., Emmerik C.L. van, Valk R.A. van der, Timmer M., Kirolos N.C.S., Ingen H. van & Noort S.J.T. van (2021), (A)Specific DNA binding of archaeal histones, the formation and positioning of hypernucleosomes, Biophysical Journal 120(3): 317a.
- Brinkmann B.W., Beijk W.F., Vlieg R.C., Noort S.J.T. van, Mejia J., Colaux J.L., Lucas S., Lamers G.E.M., Peijnenburg W.J.G.M. & Vijver M.G. (2021), Adsorption of titanium dioxide nanoparticles onto zebrafish eggs affects colonizing microbiota, Aquatic Toxicology 232: 105744.
- Henneman B., Brouwer T.B., Erkelens A.M., Kuijntjes G.A.J.T., Emmerik C. van, Valk R.A. van der, Timmer M., Kirolos N., Ingen H. van, Noort S.J.T. van & Dame R.T. (2021), Mechanical and structural properties of archaeal hypernucleosomes, Nucleic Acids Research 49(8): 4338-4394.
- Arias-Alpizar G., Kong L., Vlieg R.C., Rabe A., Papadopoulou P., Meijer M.S., Bonnet S., Vogel S., Noort J. van, Kros A. & Campbell F. (2020), Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo, Nature Communications 11: 3638.
- Brouwer T.B., Hermans N. & Noort S.J.T. van (2020), Multiplexed nanometric 3D tracking of microbeads using an FFT-phasor algorithm, Biophysical Journal 118(9): 2245-2257.
- Kaczmarczyk A., Meng H., Ordu O., Noort S.J.T. van & Dekker N.H. (2020), Chromatin fibers stabilize nucleosomes under torsional stress, Nature Communications 11(1): 126.
- Jong B.E. de & Noort S.J.T. van (2019), Overcoming chromatin barriers, eLife 8: e50761.
- Brouwer T.B., Hermans N. & Noort S.J.T. van (2019), Multiplexed nanometric 3D tracking of microbeads using a FFT-phasor algorithm, Biophysical Journal 118(9): 2245-2257.
- Nordenskiold L., Soman A., Korolev N., Wahyu S., Wong S.Y., Liew C.W., Lattmann S., Teo H.L., Noort S.J.T. van & Rhodes D. (2019), Structure and Dynamics of the Telomeric Nucleosome and Chromatin, Biophysical Journal 116(3): 71A-71A.
- Pomeren M. van, Peijnenburg W.J.G.M., Vlieg R.C., Noort S.J.T. van & Vijver M.G. (2019), The biodistribution and immuno-responses of differently shaped non-modified gold particles in zebrafish embryos, Nanotoxicology 13(4): 558-571.
- Noort S.J.T. van (23 April 2018), Ons genoom gevangen in getallen (Inaugural address. Institute of Physics, Science, Leiden). Leiden: Universiteit Leiden.
- Kaczmarczyk A., Brouwer T.B., Pham C. & Noort S.J.T. van (2018), Probing Chromatin Structure with Magnetic Tweezers. In: Yubchenko Y.L. (Ed.) Nanoscale Imaging. Methods in Molecular Biology no. 1814 New York, NY, U.S.A.: Humana Press. 297-323.
- Jong B.E. de, Brouwer T.B., Kaczmarczyk A., Visscher B. & Noort S.J.T. van (2018), Rigid Basepair Monte Carlo Simulations of One-Start and Two-Start Chromatin Fiber Unfolding by Force, Biophysical Journal 115(10): 1848-1859.
- Brouwer T.B., Kaczmarczyk A.P., Pham L. & Noort S.J.T. van (2018), Unraveling DNA Organization with Single-Molecule Force Spectroscopy Using Magnetic Tweezers. In: Dame R.T. (Ed.) Bacterial Chromatin. Methods in Molecular Biology no. 1837 New York: Humana Press. 317-349.
- Cortijo S., Charoensawan V., Brestovitsky A., Buning R., Ravarani C., Rhodes D., Noort S.J.T. van, Jaeger K.E. & Wigge P.A. (2017), Transcriptional regulation of the ambient temperature response by h2a.z nucleosomes and hsf1 transcription factors in arabidopsis, Molecular Plant 10(10): 1258-1273.
- Carozza S., Culkin J. & Noort S.J.T. van (2017), Accuracy of the detection of binding events using 3d single particle tracking, BMC Biophysics 10: 3.
- Kaczmarczyk A.P., Allahverdi A., Brouwer T.B., Nordenskiold L., Dekker N.H. & Noort S.J.T. van (2017), Single-molecule force spectroscopy on histone h4 tail cross-linked chromatin reveals fiber folding, Journal of Biological Chemistry 292: 17506-17513.
- Hermans N., Huisman J.J., Brouwer T.B., Schachner C., Heusden G.P.H., Griesenbeck J. & Noort S.J.T. van (2017), Toehold-enchanced lna probes for selective pull down and single-molecule analysis of native chromatin, Scientific Reports 7: 16721.
- Eslami-Mossallam B., Schram R.D., Tompitak M., Noort S.J.T. van & Schiessel H. (2016), Multiplexing genetic and nucleosome positioning codes: A computational approach, PloS one 11(6): 0156905.
- Eslami Mossallam B., Schiessel H. & Noort S.J.T. van (2016), Nucleosome dynamics: Sequence matters, Advances in Colloid and Interface Science 232: 101-113.
- Noort J. van (2015), Editor BMC Biophysics Member of editorial staff BMC Biophysics .
- Noort J. van (2015), Editor Nature Scientific Reports Member of editorial staff Nature Scientific Reports .
- Meng H., Andresen K. & Noort J. van (2015), Quantitative analysis of single-molecule force spectroscopy on folded chromatin fibers, Nucleic Acids Research 43: 3578-3590.
- Buning R., Kropff W., Martens K. & Noort J. van (2015), spFRET reveals changes in nucleosome breathing by neighboring nucleosomes, Journal of Physics : Condensed Matter 27 (6)(064103).
- Noort S.J.T. van (2014), BMC Biophysics Member of editorial staff BMC Biophysics .
- Meng H., Bosman J., Heijden T. van der & Noort S.J.T. van (2014), Coexistence of Twisted, Plectonemic, and Melted DNA in Small Topological Domains, Biophysical Journal 106(5): 1174-1181.
- North J.A., Simon M., Ferdinand M.B., Shoffner M.A., Picking J.W., Howard C.J., Mooney A.M., Noort S.J.T. van, Poirier M.G. & Ottesen J.J. (2014), Histone H3 phosphorylation near the nucleosome dyad alters chromatin structure, Nucleic Acids Research 42(8): 4922-4933.
- Noort S.J.T. van (2014), Nature Scientific Reports Member of editorial staff Nature Scientific Reports .
- Buning R., Kropff W., Martens C.L.G. & Noort S.J.T. van (2014), spFRET reveals changes in nucleosome breathing by neighboring nucleosomes, Journal of Physics : Condensed Matter .
- Noort S.J.T. van (2013), Member of editorial staff TheScientificWorldJournal .
- Noort S.J.T. van (2013), Member of editorial staff BMC Biophysics .
- Noort S.J.T. van (2013), Member of editorial staff Nature Scientific Reports .
- Broek B. van den, Ashcroft B.A., Oosterkamp T.H. & Noort S.J.T. van (2013), Parallel nanometric 3D tracking of intracellular gold nanorods using multifocal two-photon microscopy, Nano Letters 13(3): 980-986.
- Driessen R.P.C., Meng H., Suresh G., Shahapure R., Lanzani G., Priyakumar U.D., White M.F., Schiessel H., Noort S.J.T. van & Dame R.T. (2013), Crenarchaeal chromatin proteins Cren7 and Sul7 compact DNA by inducing rigid bends, Nucleic Acids Research 41(1): 196-205.
- Heijden T. van der, Vugt J.F.A. van, Logie C. & Noort S.J.T. van (2012), Sequence-based prediction of single nucleosome positioning and genome-wide nucleosome occupancy, Proceedings of the National Academy of Sciences of the United States of America 109(38): E2514-E2522.
- Buning R. & Noort S.J.T. van (2010), Single-pair FRET experiments on nucleosome conformational dynamics, BIOCHIMIE 92(12): 1-13.
- Chien F.-T. & Noort S.J.T. van (2009), 10 years of tension on chromatin: results fromsingle-molecule spectroscopy, Curr. Pharm. Biotechnology 10: 474-485.
- Neumann H., Hancock S.M., Buning R., Routh A., Chapman L., Somers J., Owen-Hughes T., Noort S.J.T. van, Rhodes D. & Chin J.W. (2009), A method for genetically installing site-specific acetylation in recombinant histones defines the effect of h3 k56 acetylation, MOLECULAR CELL 36: 153-163.
- Noort S.J.T. van & Jager M. de (2009), Botsende eiwitkralen leggen DNA bloot, Universitaire Nieuwsbrief 2.
- Kruithof M.C. & Noort S.J.T. van (2009), Hidden Markov analysis of nucleosome unwrapping under force, Biophysical Journal 96: 3708-3715.
- Vugt J.F.A. van, Jager M. de, Murawska M., Brehm A., Noort S.J.T. van & Logie C. (2009), Multiple aspects of atp-dependent nucleosome translocation by rsc and mi-2 are directed by the underlying dna sequence, PLoS ONE 4(7): e6345.
- Engeholm M., Jager M. de, Flaus A., Brenk R., Noort S.J.T. van & Owen-Hughes T. (2009), Nucleosomes can invade DNA territories occupied by their neighbors, Natural Structural & Molecular Biology 16: 151-158.
- Kruithof M.C., Chien F.-T., Routh A., Logie C., Rhodes D. & Noort S.J.T. van (2009), Single-molecule force spectroscopy reveals a highly compliant helical folding for the 30-nm chromatin fiber, Nature Structural & Molecular Biology 16: 534-540.
- Schaaf M., Koopmans W., Meckel T.M., Noort S.J.T. van, Snaar-Jagalska B.E., Schmidt T. & Spaink H.P. (2009), Single-molecule microscopy reveals membrane microdomain organization of cells in a living vertebrate, Biophysical Journal 97: 1206-1214.
- Koopmans W.J.A., Buning R., Schmidt T. & Noort S.J.T. van (2009), spFRET using alternating excitation and FCS reveals progressive DNA unvwrapping in nucleosomes, Biophysical Journal 97: 195-204.
- Koopmans W., Schmidt T. & Noort S.J.T. van (2008), Nucleosome immobilization strategies for single-pair FRET microscopy, CHEMPHYSCHEM 9: 2002-2009.
- Kruithof M.C., Chien F.-T., Jager M. de & Noort S.J.T. van (2008), Sub-piconeutron dynamic force spectroscopy using magnetic tweezers, Biophysical Journal 94: 2343-2348.
- Jager M. de & Noort S.J.T. van (2007), Atomic force microscopy. In: Encyclopedia of Life Sciences.: John Wiley & Sons, Ltd.. 1-10.
- Koopmans W., Brehm A., Logie C., Schmidt T. & Noort S.J.T. van (2007), Single-pair FRET microscopy reveals mononucleosome dynamics, Journal of Fluoresc. .
- Noort J. van, Verbrugge S., Goosen N., Dekker C. & Dame R.T. (2004), Dual architectural roles of HU: Formation of flexible hinges and rigid filaments, Proceedings of the National Academy of Sciences of the United States of America 101(18): 6969-6974.
- shareholder/consultant
- Visiting associate professor