Jaap Brouwer
Professor emeritus Molecular genetics
- Name
- Prof.dr. J. Brouwer
- Telephone
- +31 71 527 4755
- brouwer@chem.leidenuniv.nl
Professor emeritus Molecular genetics
- Science
- Leiden Institute of Chemistry
- Lanz H.L., Zimmerman R.M., Brouwer J., Noteborn M.H.M. & Backendorf C.M.P. (2013), Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin, Cell Death and Disease 4: .
- Baggelaar M.P., Janssen F.J., Esbroeck A.C.M. van, Dulk J. den, Allara M., Hoogendoorn S., McGuire R., Florea B.I., Meeuwenoord N.J., Elst H. van den, Marel G.A. van der, Brouwer J., Marzo V. di, Overkleeft H.S. & Stelt M. van der (2013), Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-alpha in Brain, Angewandte Chemie (International Edition) 52(46): 12081-12085.
- Vermeij W.P., Florea B.I., Isenia S., Alia A., Brouwer J. & Backendorf C.M.P. (2012), Proteomic Identification of in Vivo Interactors Reveals Novel Function of Skin Cornification Proteins, Journal of Proteome Research 11(6): 3068-3076.
- Marques-Gallego P., Den Dulk H., Backendorf C., Brouwer J., Reedijk J. & Burke J.F. (2010), Accurate non-invasive image-based cytotoxicity assays for cultured cells, BMC Biotechnology 10: 43.
- Marques-Gallego P., Kalayda G.V., Jaehde U., Den Dulk H., Brouwer J. & Reedijk J. (2009), Cellular accumulation and DNA platination of two new platinum(II) anticancer compounds based on anthracene derivatives as carrier ligands, Journal of Inorganic Biochemistry 103(5): 791-796.
- Marques-Gallego P., Contaldi S., Den Dulk H., Monari M., Brouwer J., Jaehde U., Kalayda G.V. & Reedijk J. (2009), Relevance of the leaving group for antitumor activity of new platinum(II) compounds containing anthracene derivatives as a carrier ligand, Journal of Inorganic Biochemistry 103(12): 1602-1608.
- Marques-Gallego P., Dulk H. den, Brouwer J., Kooijman H., Spek A.L., Roubeau O., Teat S.J. & Reedijk J. (2008), Synthesis, Crystal Structure, Studies in Solution and Cytotoxicity of Two New Fluorescent Platinum(II) Compounds Containing Anthracene Derivatives as a Carrier Ligand, Inorganic Chemistry 47(23): 11171-11179.
- Garza-Ortiz A., Dulk H. den, Brouwer J., Kooijman H., Spek A.L. & Reedijk J. (2007), The synthesis, chemical and biological properties of dichlorido(azpy)gold(III) chloride (azpy=2-(phenylazo)pyridine) and the gold-induced conversion of the azpy ligand to the chloride of the novel tricyclic pyrido[2,1-c][1,2,4]benzotriazin-11-ium cation, Journal of Inorganic Biochemistry 101(11-12): 1922-1930.
- Zutphen S.M. van, Pantoja E., Soriano R., Soro C., Tooke D.M., Spek A.L., Dulk H. den, Brouwer J. & Reedijk J. (2006), New antitumour active platinum compounds containing carboxylate ligands in trans geometry: synthesis, crystal structure and biological activity, Dalton Transactions 2006(8): 1020-1023.
- Rijt S. van, Zutphen S.M. van, Dulk H. den, Brouwer J. & Reedijk J. (2006), Structure-activity relationship studies for three new asymmetric cis-platinum(II) aminoethanol-based complexes, Inorganica Chimica Acta 359(12): 4125-4129.
- Jansen B.A.J., Wielaard P., Kalayda G.V., Ferrari M., Molenaar C., Tanke H.J., Brouwer J. & Reedijk J. (2004), Dinuclear platinum complexes with N,N '-bis(aminoalkyl)-1,4-diaminoanthraquinones as linking ligands. Part I. Synthesis, cytotoxicity, and cellular studies in A2780 human ovarian carcinoma cells, Journal of Biological Inorganic Chemistry 9: 403-413.
- Zutphen S.M. van, Robillard M.S., Marel G.A. van der, Overkleeft H.S., Dulk H. den, Brouwer J. & Reedijk J. (2003), Extending solid phase methods in inorganic synthesis: the first dinuclear platinum complex synthesized via the solid phase, Chemical Communications 2003(5): 634-635.
- Jansen B.A.J., Brouwer J. & Reedijk J. (2002), Glutathione induces cellular resistance against cationic dinuclear platinum anticancer drugs, Journal of Inorganic Biochemistry 89(3-4): 197-202.
- Jansen B.A.J., Wielaard P., Dulk H. den, Brouwer J. & Reedijk J. (2002), Oxa-aza crown ethers as ligands for mixed-ligand cisplatin derivatives and dinuclear platinum anticancer drugs, European Journal of Inorganic Chemistry 2002(9): 2375-2379.
- Robillard M.S., Jansen B.A.J., Lochner M., Geneste M., Brouwer J., Hesse M. & Reedijk J. (2001), Mononuclear tetraamineplatinum(II) complexes: Synthesis, anticancer activity, DNA binding, and cellular uptake, Helvetica Chimica Acta 84(10): 3023-3030.
- Jansen B.A.J., Zwan J. van der, Dulk H. den, Brouwer J. & Reedijk J. (2001), Dinuclear alkyldiamine platinum antitumor compounds: A structure-activity relationship study, Journal of Medicinal Chemistry 44(2): 245-249.
- Jansen B.A.J., Zwan J. van der, Reedijk J., Dulk H. den & Brouwer J. (1999), A tetranuclear platinum compound designed to overcome cisplatin resistance, European Journal of Inorganic Chemistry 1999(9): 1429-1433.
- Jansen B.A.J., Zwam J. van der, Reedijk J., Dulk H. den & Brouwer J. (1999), A tetranuclear platinum compound designed to overcome cisplatin resistance, Genomics 55(9): 88-99.
- Tijsterman M., Pril R. de, Tasseron-de Jong J.G. & Brouwer J. (1998), RNA polymerase II transcription suppresses nucleosomal modulation of UV-induced (6-4) photoproduct and cyclobutane pyrimidine dimer repair in yeast, Molecular and Cellular Biology 19: 934-940.
- Brouwer J., Fichtinger-Schepman A.M.J., Putte P. van de & Reedijk J. (1982), Influence of temperature on platinum binding to DNA, cell killing, and mutation induction in escherichia-coli K-12 cells treated with cis-diamminedichloroplatinum(II), Cancer Research 42(6): 2416-2419.
- Brouwer J., Putte P. van de, Fichtinger-Schepman A.M.J. & Reedijk J. (1981), Base pair substitution hotspots in GAG and GCG nucleotide-sequences in Escherichia coli K-12 induced by cis-diamminedichloroplatinum-(II), Proceedings of the National Academy of Sciences 78(11): 7010-7014.