Universiteit Leiden

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Research project

Microfluidics for high-throughput liposome formulation for personalized cancer vaccination

Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very short vaccine development times. Besides, intradermal vaccination with conventional needles is painful and difficult to perform. A more sophisticated manner to vaccinate intradermally is by using microneedles, which are needle-like structures with dimensions in the micrometer range that are used to deliver drugs in a pain-free manner into the skin. Therefore, his current research is focused on (1) microfluidics for high-throughput liposome formulation to encapsulate peptides for personalized cancer vaccination and (2) microneedle-based intradermal delivery of peptide-based vaccines.

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