Universiteit Leiden

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Research project

GRASP: AI-enabled Gene Regulatory Analysis for Crop Stress Resilience

How can artificial intelligence help reveal the gene regulatory mechanisms that enable crops to respond to environmental stress and disease, ultimately supporting the development of more resilient agriculture?

Duration
2027 - 2028
Contact
Pingtao Ding
Funding
European Research Council (ERC) European Research Council (ERC)

Description

Climate change and emerging plant diseases are placing increasing pressure on global food production. Improving crop resilience requires a better understanding of how plants regulate their responses to environmental stress.

The GRASP project develops computational approaches that combine artificial intelligence with plant genomics to identify gene regulatory networks involved in stress responses. Rather than focusing on individual genes, the project aims to understand how groups of genes work together over time to coordinate plant defence and adaptation.

By integrating biological knowledge with advanced computational analysis, GRASP seeks to generate interpretable predictions that can support hypothesis generation and future crop research. The project will establish computational resources that facilitate the analysis of complex plant genomic datasets and contribute to the broader field of systems biology.

Plant responses to environmental stress
Plant responses to environmental stress are controlled by complex gene regulatory networks.

In the longer term, this research may support the development of innovative strategies for improving crop resilience and promoting more sustainable agriculture.

Gene regulatory network analysis
Artificial intelligence can help uncover dynamic gene regulatory networks that support future crop resilience research.

The Ding Lab investigates plant immunity and systems biology using experimental and computational approaches.

The current Ding Lab team
The current Ding Lab team members (2026)
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