Universiteit Leiden

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Research project

Characterization of Cell-based medicinal products (CBMPs)

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using a set of complementary analytical tools, such as cell viability assays and (flow) imaging techniques with the aim to gain insight into the stability of CBMPs under different formulation, storage, handling and stress conditions. Consequently, CBMP characterization will set a path to the optimization of production, formulation, storage and handling protocols. This should lead to improvement of the safety and efficacy of CBMPs in clinical practice.

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