Universiteit Leiden

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Dissertation

Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial mechanism of action (MoA) identification.

Author
Ouyang, X.
Date
23 November 2021
Links
Thesis in Leiden Repository

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial mechanism of action (MoA) identification. With this strategy, we have discovered several interesting antimicrobial agents and have demonstrated the detailed antimicrobial property of two of them, berkchaetoazaphilone B (BAB) and harzianic acid (HA).

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