Dissertation

mRNA and drug delivery with lipid-based nanoparticles

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Author

Zeng, Y.

Date

06 December 2022

Links

Thesis in Leiden Repository

We have modified liposomes and LNPs with fusogenic coiled-coil peptides to enhance the drug/mRNA delivery efficiency (Chapter 2-4), and also investigated how the lipid composition of LNPs influences the immune response (Chapter 5).