Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken
- M.I. Ries
- 25 February 2014
- Thesis in Leiden Repository
This dissertation describes the development and application of new mass spectrometry based tools which were used for the identification of various secondary metabolite pathways present in the fungus Penicillium chrysogenum. Using these tools the biosynthesis of metabolites like roquefortine, meleagrin and fungisporin could be elucidated.