Lecture
LCN2 seminar March 2025
- Date
- Friday 28 March 2025
- Time
- Location
- Gorlaeus
- Room
- BM. 2.26
73rd LCN2 seminar
Speaker: Koen Keijzer (Universiteit Leiden)
Title: Hybrid models of cell and extracellular matrix mechanics
Abstract: Traditional social network analysis often models homophily-the tendency of similar individuals to form connections-using a single parameter. We will show that in many important applications, such as hypergraphs or temporal contact networks, homophily occurs at several different scales. We present a model that integrates these different homophily values through a maximum entropy approach. We demonstrate that the interaction beComputational models often help to understand multiscale mechanisms in biological situations. We will discuss computational models aimed to capture the mechanical interplay between biological cells and the extracellular matrix (ECM). The ECM is a network of fibrous non-cellular objects that form the scaffold of the tissues in our bodies. Cells respond to changes in ECM structure, such as stiffness and isotropy of the fibrous network. In this talk we will first consider the model of Glazier-Graner-Hogeweg (GGH, also known as the cellular Potts model), which is a computational model for biological cells. Then, we discuss how different models of ECM can be coupled to the GGH model and how these hybrid models can give insight in biological mechanisms involving the mechanical properties of ECM such as stiffness and anisotropy.tween different levels of homophily results in complex percolation thresholds. Furthermore, we show that our model fits remarkably well on a wide range of data sets, capturing their homophily patterns accurately.
Snacks and drinks will be available after the seminar at the Fusiebar.