Universiteit Leiden

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PhD defence

Exploration of the endocannabinoid system using metabolomics

  • X. Di
Date
Tuesday 7 February 2023
Time
Location
Academy Building
Rapenburg 73
2311 GJ Leiden

Summary

To increases clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

In this thesis, we focus on the endocannabinoid system (ECS) and profiling its related metabolic pathways using liquid chromatography - mass spectrometry (LC-MS) based metabolomics techniques. The endocannabinoid system (ECS) is a signaling system involved in multiple physiological and pathological processes. Due to its wide distribution and complex network of metabolic interactions, the development of drugs targeting the ECS has seen high failure rates. To get a better understanding of the behavior of the ECS and related pathways, LC-MS platforms with wide coverage of the major ECS-related metabolites, or with high sensitivity that reaches low levels of metabolites, were developed and optimized. Furthermore, these metabolomics platforms were applied in clinical studies looking into cardiometabolic health, and revealed correlations between endogenous metabolite signaling, cardiometabolic health and the benefits of exercise.  

Supervisor(s)

  • Prof. T. Hankemeier

PhD dissertations

PhD dissertations by Leiden PhD students are available digitally after the defence through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.

Press enquiries (journalists only)

Marieke Epping
Scientific communication adviser
m.epping@bb.leidenuniv.nl
071 527 1521

General information

Beadle's Office
pedel@bb.leidenuniv.nl
+31 71 527 7211

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