Peter Kuppen
- Name
- Dr. P.J.K. Kuppen
- Telephone
- +31 71 526 4569
- p.j.k.kuppen@lumc.nl
- Faculteit Geneeskunde
- LUMC - Medische Faculteit Leiden
- Divisie 1
- Heelkunde
- Meijer, R.P.J.; Neijenhuis, L.K.A.; Zeilstra, A.P.; Roerink, S.F.; Bhairosingh, S.S.; Hilling, D.E.; Mieog, J.S.D.; Kuppen, P.J.K.; Sier, C.F.M.; Braun, J.; Burggraaf, J.; Vahrmeijer, A.L.; Cohen, D. & Hutteman, M. (2022), Data-driven identification of targets for fluorescence-guided surgery in non-small cell lung cancer, Molecular Imaging and Biology 25.
- Unlu, B.; Kocaturk, B.; Rondon, A.M.R.; Lewis, C.S.; Swier, N.; Akker, R.F.P. van den; Krijgsman, D.; Noordhoek, I.; Blok, E.J.; Bogdanov, V.Y.; Ruf, W.; Kuppen, P.J.K. & Versteeg, H.H. (2022), Integrin regulation by tissue factor promotes cancer stemness and metastatic dissemination in breast cancer, Oncogene 41(48): 5176-5185.
- Weerd, S. van de; Smit, M.A.; Roelands, J.; Mesker, W.E.; Bedognetti, D.; Kuppen, P.J.K.; Putter, H.; Tollenaar, R.A.E.M.; Roodhart, J.M.L.; Hendrickx, W.; Medema, J.P. & Krieken, J.H.J.M. van (2022), Correlation of immunological and histopathological features with gene expression-based classifiers in colon cancer patients, International Journal of Molecular Sciences 23(20).
- Linders, D.G.J.; Bijlstra, O.D.; Fallert, L.C.; Hilling, D.E.; Walker, E.; Straight, B.; March, T.L.; Valentijn, A.R.P.M.; Pool, M.; Burggraaf, J.; Basilion, J.P.; Vahrmeijer, A.L. & Kuppen, P.J.K. (2022), Cysteine cathepsins in breast cancer, Molecular Imaging and Biology 25.
- Anijs, R.J.S.; Laghmani, E.; Unlu, B.; Kielbasa, S.M.; Mei, H.L.; Cannegieter, S.C.; Klok, F.A.; Kuppen, P.J.K.; Versteeg, H.H. & Buijs, J.T. (2022), Tumor-expressed microRNAs associated with venous thromboembolism in colorectal cancer, Research and Practice in Thrombosis and Haemostasis 6(5).
- Michelakos, T.; Kontos, F.; Kurokawa, T.; Cai, L.; Sadagopan, A.; Krijgsman, D.; Weichert, W.; Durrant, L.G.; Kuppen, P.J.K.; Ferrone, C.R. & Ferrone, S. (2022), Differential role of HLA-A and HLA-B, C expression levels as prognostic markers in colon and rectal cancer, Journal for ImmunoTherapy of Cancer 10(3).
- Neijenhuis, L.K.A.; Myunck, L.D.A.N. de; Bijlstra, O.D.; Kuppen, P.J.K.; Hilling, D.E.; Borm, F.J.; Cohen, D.; Mieog, J.S.D.; Steup, W.H.; Braun, J.; Burggraaf, J.; Vahrmeijer, A.L. & Hutteman, M. (2022), Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review, Life 12(3).
- Rademaker, E.; Bastiaannet, E.; Oosting, J.; Dekker-Ensink, N.G.; Kuppen, P.J.K.; Miranda, N.F.C.C. de & Liefers, G.J. (2022), Revising the role of integrin subunit beta 4 expression in colon cancer progression and survival, Journal of Gastrointestinal Cancer.
- Dam, M.A. van; Vuijk, F.A.; Stibbe, J.A.; Houvast, R.D.; Luelmo, S.A.C.; Crobach, S.; Feshtali, S.S.; Geus-Oei, L.F. de; Bonsing, B.A.; Sier, C.F.M.; Kuppen, P.J.K.; Swijnenburg, R.J.; Windhorst, A.D.; Burggraaf, J.; Vahrmeijer, A.L. & Mieog, J.S.D. (2021), Overview and future perspectives on tumor-targeted positron emission tomography and fluorescence imaging of pancreatic cancer in the era of neoadjuvant therapy, Cancers 13(23).
- Houvast, R.D.; Thijse, K.; Groen, J.V.; Chua, J.X.; Vankemmelbeke, M.; Durrant, L.G.; Mieog, J.S.D.; Bonsing, B.A.; Vahrmeijer, A.L.; Kuppen, P.J.K.; Crobach, A.S.L.P. & Sier, C.F.M. (2021), An immunohistochemical evaluation of tumor-associated glycans and mucins as targets for molecular imaging of Pancreatic Ductal Adenocarcinoma, Cancers 13(22).
- Baart, V.M.; Manen, L. van; Bhairosingh, S.S.; Vuijk, F.A.; Iamele, L.; Jonge, H. de; Scotti, C.; Resnati, M.; Cordfunke, R.A.; Kuppen, P.J.K.; Mazar, A.P.; Burggraaf, J.; Vahrmeijer, A.L. & Sier, C.F.M. (2021), Side-by-side comparison of uPAR-targeting optical imaging antibodies and antibody fragments for fluorescence-guided surgery of solid tumors, Molecular Imaging and Biology.
- Water, R.B. van de; Krijgsman, D.; Houvast, R.D.; Vahrmeijer, A.L. & Kuppen, P.J.K. (2021), A critical assessment of the association between HLA-G expression by carcinomas and clinical outcome, International Journal of Molecular Sciences 22(15).
- Baart, V.M.; Horst, G. van der; Deken, M.M.; Bhairosingh, S.S.; Schomann, T.; Sier, V.Q.; Mark, M.H. van der; Iamele, L.; Jonge, H. de; Resnati, M.; Mazar, A.P.; Pelger, R.C.M.; Pluijm, G. van der; Kuppen, P.J.K.; Vahrmeijer, A.L. & Sier, C.F.M. (2021), A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma, European Journal of Cancer 146: 11-20.
- Linders, D.; Deken, M.; Valk, M. van der; Tummers, W.; Bhairosingh, S.; Schaap, D.; Lijnschoten, G. van; Zonoobi, E.; Kuppen, P.; Velde, C. van de; Vahrmeijer, A.; Sarasqueta, A.F.; Sier, C. & Hilling, D. (2021), CEA, EpCAM, alpha v beta 6 and uPAR expression in rectal cancer patients with a pathological complete response after neoadjuvant therapy, Diagnostics 11(3).
- Rijs, Z.; Shifai, A.N.; Bosma, S.E.; Kuppen, P.J.K.; Vahrmeijer, A.L.; Keereweer, S.; Bovee, J.V.M.G.; Sande, M.A.J. van de; Sier, C.E.M. & Driel, P.B.A.A. van (2021), Candidate biomarkers for specific intraoperative near-infrared imaging of soft tissue sarcomas: a systematic review, Cancers 13(3).
- Roelands, J.; Mall, R.; Almeer, H.; Thomas, R.; Mohamed, M.G.; Bedri, S.; Al-Bader, S.B.; Junejo, K.; Ziv, E.; Sayaman, R.W.; Kuppen, P.J.K.; Bedognetti, D.; Hendrickx, W. & Decock, J. (2021), Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry, npj Breast Cancer 7.
- Baart, V.M.; Deken, M.M.; Bordo, M.W.; Bhairosingh, S.S.; Salvatori, D.C.F.; Hyun, H.; Henary, M.; Choi, H.S.; Sier, C.F.M.; Kuppen, P.J.K.; Scheltinga, A.G.T.T. van; March, T.L.; Valentijn, A.R.P.M.; Frangioni, J.V. & Vahrmeijer, A.L. (2020), Small molecules for multi-wavelength near-infrared fluorescent mapping of regional and sentinel lymph nodes in colorectal cancer staging, Frontiers in Oncology 10.
- Nazemalhosseini-Mojarad, E.; Asadzadeh-Aghdaei, H.; Mohammadpour, S.; Esfahani, A.T.; Porhoseingholi, M.A.; Molaei, M.; Jalali, A.; Kuppen, P.J.K. & Zali, M.R. (2020), Downregulation of human leukocyte antigen Class I expression, Journal of Cancer Research and Therapeutics 16: S165-S171.
- Krijgsman, D.; Roelands, J.; Andersen, M.N.; Wieringa, C.H.L.A.; Tollenaar, R.A.E.M.; Hendrickx, W.; Bedognetti, D.; Hokland, M. & Kuppen, P.J.K. (2020), Expression of NK cell receptor ligands in primary colorectal cancer tissue in relation to the phenotype of circulating NK- and NKT cells, and clinical outcome, Molecular Immunology 128: 205-218.
- Houvast, R.D.; Vankemmelbeke, M.; Durrant, L.G.; Wuhrer, M.; Baart, V.M.; Kuppen, P.J.K.; Geus-Oei, L.F. de; Vahrmeijer, A.L. & Sier, C.E.M. (2020), Targeting glycans and heavily glycosylated proteins for tumor imaging, Cancers 12(12).
- Attia, J.V.D.; Dessens, C.E.; Water, R. van de; Houvast, R.D.; Kuppen, P.J.K. & Krijgsman, D. (2020), The molecular and functional characteristics of HLA-G and the interaction with its receptors: where to intervene for cancer immunotherapy?, International Journal of Molecular Sciences 21(22).
- Vuijk, F.A.; Muynck, L.D.A.N. de; Ranken, L.C.F.; Busch, O.R.; Wilmink, J.W.; Besselink, M.G.; Bonsing, B.A.; Bhairosingh, S.S.; Kuppen, P.J.K.; Mieog, J.S.D.; Sier, C.F.M.; Vahrmeijer, A.L.; Verheij, J.; Farina-Sarasqueta, A. & Swijnenburg, R.J. (2020), Molecular targets for diagnostic and intraoperative imaging of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX treatment, Scientific Reports 10(1).
- Houvast, R.D.; Baart, V.M.; Bhairosingh, S.S.; Cordfunke, R.A.; Chua, J.X.; Vankemmelbeke, M.; Parsons, T.; Kuppen, P.J.K.; Durrant, L.G.; Vahrmeijer, A.L. & Sier, C.F.M. (2020), Glycan-based near-infrared fluorescent (NIRF) imaging of gastrointestinal tumors, Molecular Imaging and Biology 22.
- Krijgsman, D.; Vries, N.L. de; Andersen, M.N.; Skovbo, A.; Tollenaar, R.A.E.M.; Moller, H.J.; Hokland, M. & Kuppen, P.J.K. (2020), CD163 as a biomarker in colorectal cancer, International Journal of Molecular Sciences 21(16).
- Muijnck, C. de; Gorkom, Y. van; Duijvenvoorde, M. van; Eghtesadi, M.; Dekker-Ensink, G.; Bhairosingh, S.S.; Affinito, A.; Kuppen, P.J.K.; Vahrmeijer, A.L. & Sier, C.F.M. (2020), Evaluation of EphB4 as target for image-guided surgery of breast cancer, Pharmaceuticals 13(8).
- Baart, V.M.; Houvast, R.D.; Geus-Oei, L.F. de; Quax, P.H.A.; Kuppen, P.J.K.; Vahrmeijer, A.L. & Sier, C.F.M. (2020), Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer, EJNMMI Research 10(1).
- Krijgsman, D.; Vries, N.L. de; Andersen, M.N.; Skovbo, A.; Tollenaar, R.A.E.M.; Bastiaannet, E.; Kuppen, P.J.K. & Hokland, M. (2020), The effects of tumor resection and adjuvant therapy on the peripheral blood immune cell profile in patients with colon carcinoma, Cancer Immunology, Immunotherapy 69.
- Inda, M.A.; Blok, E.J.; Kuppen, P.J.K.; Charehbili, A.; Biezen-Timmermans, E.C. den; Brussel, A. van; Fruytier, S.E.; Kranenbarg, E.M.K.; Kloet, S.; Burg, B. van der; Martens, J.W.M.; Sims, A.H.; Turnbull, A.K.; Dixon, J.M.; Verhaegh, W.; Kroep, J.R.; Velde, C.J.H. van de & Stolpe, A. van de (2020), Estrogen receptor pathway activity score to predict clinical response or resistance to neoadjuvant endocrine therapy in primary breast cancer, Molecular Cancer Therapeutics 19(2): 680-689.
- Roelands, J.; Hendrickx, W.; Zoppoli, G.; Mall, R.; Saad, M.; Halliwill, K.; Curigliano, G.; Rinchai, D.; Decock, J.; Delogu, L.G.; Turan, T.; Samayoa, J.; Chouchane, L.; Ballestrero, A.; Wang, E.; Finetti, P.; Bertucci, F.; Miller, L.D.; Galon, J.; Marincola, F.M.; Kuppen, P.J.K.; Ceccarelli, M. & Bedognetti, D. (2020), Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response, Journal for ImmunoTherapy of Cancer 8(1).
- Krijgsman, D.; Vlierberghe, R.L.P. van; Evangelou, V.; Vahrmeijer, A.L.; Velde, C.J.H. van de; Sier, C.F.M. & Kuppen, P.J.K. (2019), A method for semi-automated image analysis of HLA class I tumour epithelium expression in rectal cancer, European Journal of Histochemistry 63(2): 88-95.
- Kuninty, P.R.; Bansal, R.; Geus, S.W.L. de; Mardhian, D.F.; Schnittert, J.; Baarlen, J. van; Storm, G.; Bijlsma, M.F.; Laarhoven, H.W. van; Metselaar, J.M.; Kuppen, P.J.K.; Vahrmeijer, A.L.; Ostman, A.; Sier, C.F.M. & Prakash, J. (2019), ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer, Science Advances 5(9).
- Sobral-Leite, M.; Salomon, I.; Opdam, M.; Kruger, D.T.; Beelen, K.J.; Noort, V. van der; Vlierberghe, R.L.P. van; Blok, E.J.; Giardiello, D.; Sanders, J.; Vijver, K. van de; Horlings, H.M.; Kuppen, P.J.K.; Linn, S.C.; Schmidt, M.K. & Kok, M. (2019), Cancer-immune interactions in ER-positive breast cancers, Breast Cancer Research 21(1).
- Krijgsman, D.; Vries, N.L. de; Skovbo, A.; Andersen, M.N.; Swets, M.; Bastiaannet, E.; Vahrmeijer, A.L.; Velde, C.J.H. van de; Heemskerk, M.H.M.; Hokland, M. & Kuppen, P.J.K. (2019), Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile, Cancer Immunology, Immunotherapy 68(6): 1011-1024.
- Groot, A.F. de; Blok, E.J.; Charehbili, A.; Engels, C.C.; Smit, V.T.H.B.M.; Dekker-Ensink, N.G.; Putter, H.; Kranenbarg, E.M.K.; Velde, C.J.H. van de; Liefers, G.J.; Nortier, J.W.R.; Kuppen, P.J.K.; Burg, S.H. van der & Kroep, J.R. (2019), Strong CD8+lymphocyte infiltration in combination with expression of HLA class I is associated with better tumor control in breast cancer patients treated with neoadjuvant chemotherapy, Breast Cancer Research and Treatment 175(3): 605-615.
- Nazemalhosseini-Mojarad, E.; Mohammadpour, S.; Esafahani, A.T.; Gharib, E.; Larki, P.; Moradi, A.; Porhoseingholi, M.A.; Aghdaei, H.A.; Kuppen, P.J.K. & Zali, M.R. (2019), Intratumoral infiltrating lymphocytes correlate with improved survival in colorectal cancer patients: Independent of oncogenetic features, Journal of Cellular Physiology 234(4): 4768-4777.
- Boogerd, L.S.F.; Boonstra, M.C.; Prevoo, H.A.J.M.; Handgraaf, H.J.M.; Kuppen, P.J.K.; Velde, C.J.H. van de; Fish, A.; Cordfunke, R.A.; Valentijn, A.R.P.M.; Scheltinga, A.G.T. van; MacDonald, G.C.; Cizeau, J.; Premsukh, A.; Slooten, M.L.V. van; Burggraaf, J.; Sier, C.F.M. & Vahrmeijer, A.L. (2019), Fluorescence-guided tumor detection with a novel anti-EpCAM targeted antibody fragment: Preclinical validation, Surgical Oncology 28: 1-8.
- Vangangelt, K.M.H.; Tollenaar, L.S.A.; Pelt, G.W. van; Kruijf, E.M. de; Dekker, T.J.A.; Kuppen, P.J.K.; Tollenaar, R.A.E.M. & Mesker, W.E. (2018), The prognostic value of tumor-stroma ratio in tumor-positive axillary lymph nodes of breast cancer patients, International Journal of Cancer 143(12): 3194-3200.
- Trinh, A.; Ladrach, C.; Dawson, H.E.; Hoorn, S. ten; Kuppen, P.J.K.; Reimers, M.S.; Koopman, M.; Punt, C.J.A.; Lugli, A.; Vermeulen, L. & Zlobec, I. (2018), Tumour budding is associated with the mesenchymal colon cancer subtype and RAS/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data, British Journal of Cancer 119(10): 1244-1251.
- Swets, M.; Wouters, A.; Krijgsman, D.; Vlierberghe, R.L.P. van; Boot, A.; Eendenburg, J.D. van; Wezel, T. van; Gelderblom, H.; Velde, C.J.H. van de; Elsen, P.J. van den & Kuppen, P.J.K. (2018), HLA-G protein expression in colorectal cancer evaluated by immunohistochemistry and western blot analysis: Its expression characteristics remain enigmatic, Clinical Immunology 194: 80-86.
- Blok, E.J.; Engels, C.C.; Dekker-Ensink, G.; Kranenbarg, E.M.K.; Putter, H.; Smit, V.T.H.B.M.; Liefers, G.J.; Morden, J.P.; Bliss, J.M.; Coombes, R.C.; Bartlett, J.M.S.; Kroep, J.R.; Velde, C.J.H. van de & Kuppen, P.J.K. (2018), Exploration of tumour-infiltrating lymphocytes as a predictive biomarker for adjuvant endocrine therapy in early breast cancer, Breast Cancer Research and Treatment 171(1): 65-74.
- Vangangelt, K.M.H.; Tollenaar, L.S.A.; Pelt, G.W. van; Kruijf, E.M. de; Dekker, T.J.A.; Kuppen, P.J.K.; Tollenaar, R.A.E.M. & Mesker, W.E. (2018), The prognostic value of tumor-stroma ratio in tumor-positive axillary lymph nodes of breast cancer patients, International Journal of Cancer.
- Vangangelt, K.M.H.; Pelt, G.W. van; Engels, C.C.; Putter, H.; Liefers, G.J.; Smit, V.T.H.B.M.; Tollenaar, R.A.E.M.; Kuppen, P.J.K. & Mesker, W.E. (2018), Prognostic value of tumor-stroma ratio combined with the immune status of tumors in invasive breast carcinoma, Breast Cancer Research and Treatment 168(3): 601-612.
- Unlu, B.; Es, N. van; Arindrarto, W.; Kielbasa, S.M.; Mei, H.; Westerga, J.; Middeldorp, S.; Kuppen, P.J.K.; Otten, J.M.M.B.; Cannegieter, S. & Versteeg, H.H. (2018), Genes associated with venous thromboembolism in colorectal cancer patients, Journal of Thrombosis and Haemostasis 16(2): 293-302.
- Krijgsman, D.; Hokland, M. & Kuppen, P.J.K. (2018), The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach, Frontiers in Immunology 9.
- Swets, M.; Kuppen, P.J.K.; Blok, E.J.; Gelderblom, H.; Velde, C.J.H. van de & Nagtegaal, I.D. (2018), Are pathological high-risk features in locally advanced rectal cancer a useful selection tool for adjuvant chemotherapy?, European Journal of Cancer 89: 1-8.
- Guo, J.M.; Fung, B.C.M.; Iqbal, F.; Kuppen, P.J.K.; Tollenaar, R.A.E.M.; Mesker, W.E. & Lebrun, J.J. (2017), Revealing determinant factors for early breast cancer recurrence by decision tree, Information Systems Frontiers 19(6): 1233-1241.
- Groot, A.F. de; Blok, E.J.; Charehbili, A.; Engels, C.C.; Smit, V.T.H.B.M.; Dekker-Ensink, N.G.; Putter, H.; Velde, C.J.H.V. de; Liefers, G.J.; Nortier, J.W.R.; Kuppen, P.J.K.; Burg, S.H. van der & Kroep, J.R. (2017), Tumor-infiltrating lymphocytes, tumor-associated macrophages and HLA class 1 expression in breast cancer patients treated with neoadjuvant chemotherapy with or without zoledronic acid: A sub study of the NEOZOTAC trial, Annals of Oncology 28.
- Vangangelt, K.M.H.; Pelt, G.W. van; Engels, C.C.; Putter, H.; Liefers, G.J.; Smit, V.T.H.B.M.; Tollenaar, R.A.E.M.; Kuppen, P.J.K. & Mesker, W.E. (2017), Prognostic value of tumor-stroma ratio combined with the immune status of tumors in invasive breast carcinoma., Breast Cancer Research and Treatment.
- Roelands, J.; Kuppen, P.J.K.; Vermeulen, L.; Maccalli, C.; Decock, J.; Wang, E.; Marincola, F.M.; Bedognetti, D. & Hendrickx, W. (2017), Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications, International Journal of Molecular Sciences 18(10).
- Boot, A.; Oosting, J.; Eendenburg, J.D.H. van; Kuppen, P.J.K.; Morreau, H. & Wezel, T. van (2017), Methylation associated transcriptional repression of ELOVL5 in novel colorectal cancer cell lines, PLoS ONE 12(9).
- Voorneveld, P.W.; Reimers, M.S.; Bastiaannet, E.; Jacobs, R.J.; Eijk, R. van; Zanders, M.M.J.; Herings, R.M.C.; Herk-Sukel, M.P.P. van; Kodach, L.L.; Wezel, T. van; Kuppen, P.J.K.; Morreau, H.; Velde, C.J.H.V. de; Hardwick, J.C.H. & Liefers, G.J. (2017), Statin Use After Diagnosis of Colon Cancer and Patient Survival, Gastroenterology 153(2): 470-+.
- Tummers, W.S.; Farina-Sarasqueta, A.; Boonstra, M.C.; Prevoo, H.A.; Sier, C.F.; Mieog, J.S.; Morreau, J.; Eijck, C.H. van; Kuppen, P.J.; Velde, C.J. van de; Bonsing, B.A.; Vahrmeijer, A.L. & Swijnenburg, R.J. (2017), Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma, Oncotarget 8(34): 56816-56828.
- Geus, S.W.L. de; Baart, V.M.; Boonstra, M.C.; Kuppen, P.J.K.; Prevoo, H.A.J.M.; Mazar, A.P.; Bonsing, B.A.; Morreau, H.; Velde, C.J.H. van de; Vahrmeijer, A.L. & Sier, C.F.M. (2017), Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells, Biomarker Insights 12: 1-9.
- Geus, S.W.L. de; Baart, V.M.; Boonstra, M.C.; Kuppen, P.J.K.; Prevoo, H.A.J.M.; Mazar, A.P.; Bonsing, B.A.; Morreau, H.; Velde, C.J.H. van de; Vahrmeijer, A.L. & Sier, C.F.M. (2017), Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells, Biomarker Insights 12: 1-9.
- Peters, I.T.A.; Steen, M.A. van der; Huisman, B.W.; Hilders, C.G.J.M.; Smit, V.T.H.B.M.; Vahrmeijer, A.L.; Sier, C.F.M.; Trimbos, J.B. & Kuppen, P.J.K. (2017), Morphological and phenotypical features of ovarian metastases in breast cancer patients, BMC Cancer 17.
- Blok, E.J.; Derks, M.G.M.; Kuppen, P.J.K.; Kranenbarg, E.M.M.K.; Engels, C.C.; Liefers, G.J.; Putter, H.; Seynaeve, C.M.; Kroep, J.R.; Nortier, J.W.R.; Rea, D.W.; Hasenburg, A.; Markopoulos, C.J.; Paridaens, R.; Bartlett, J.M.S. & Velde, C.J.H. van de (2017), 10-year follow-up and biomarker discovery for adjuvant endocrine therapy; results of the TEAM trial, Cancer Research 77.
- Blok, E.J.; Bulk, J. van den; Dekker-Ensink, N.G.; Derr, R.; Kanters, C.; Bastiaannet, E.; Kroep, J.R.; Velde, C.J.H. van de & Kuppen, P.J.K. (2017), Combined evaluation of the FAS cell surface death receptor and CD8+tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer, Oncotarget 8(9): 15610-15620.
- Stammes, M.A.; Prevoo, H.A.J.M.; Horst, M.C. ter; Groot, S.A.; Velde, C.J.H. van de; Chan, A.B.; Geus-Oei, L.F. de; Kuppen, P.J.K.; Vahrmeijer, A.L.; Pasquale, E.B. & Sier, C.F.M. (2017), Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery, International Journal of Molecular Sciences 18(2).
- Trinh, A.; Trumpi, K.; Melo, F.D.S.E.; Wang, X.; Jong, J.H. de; Fessler, E.; Kuppen, P.J.K.; Reimers, M.S.; Swets, M.; Koopman, M.; Nagtegaal, I.D.; Jansen, M.; Hooijer, G.K.J.; Offerhaus, G.J.A.; Kranenburg, O.; Punt, C.J.; Medema, J.P.; Markowetz, F. & Vermeulen, L. (2017), Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry, Clinical Cancer Research 23(2): 387-398.
- Swets, M.; Zaalberg, A.; Boot, A.; Wezel, T. van; Frouws, M.A.; Bastiaannet, E.; Gelderblom, H.; Velde, C.J.H. van de & Kuppen, P.J.K. (2017), Tumor LINE-1 Methylation Level in Association with Survival of Patients with Stage II Colon Cancer, International Journal of Molecular Sciences 18(1).
- Peters, I.T.A.; Zwet, E.W. van; Smit, V.T.H.B.M.; Liefers, G.J.; Kuppen, P.J.K.; Hilders, C.G.J.M. & Trimbos, J.B. (2017), Prevalence and Risk Factors of Ovarian Metastases in Breast Cancer Patients < 41 Years of Age in the Netherlands: A Nationwide Retrospective Cohort Study, PLoS ONE 12(1).
- Frouws, M.A.; Reimers, M.S.; Swets, M.; Bastiaannet, E.; Prinse, B.; Eijk, R. van; Lemmens, V.E.P.P.; Herk-Sukel, M.P.P. van; Wezel, T. van; Kuppen, P.J.K.; Morreau, H.; Velde, C.J.H. van de & Liefers, G.J. (2017), The Influence of BRAF and KRAS Mutation Status on the Association between Aspirin Use and Survival after Colon Cancer Diagnosis, PLoS ONE 12(1).
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- Kruijf, E. de; Bastiaannet, E.; Ruberta, F.; Sorlie, T.; Craen, A.J.M. de; Kuppen, P.J.K.; Smit, V.; Velde, C.J.H. van de & Liefers, G.J. (2012), Comparison of Frequencies and Prognostic Effect of Molecular Subtypes Between Young and Elderly Breast Cancer Patients, European Journal of Cancer 48: S129-S130.
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- Iersel, L.B.J. van; Koopman, M.; Velde, C.J.H.V. de; Mol, L.; Meerten, E.L.V.P. van; Hartgrink, H.H.; Kuppen, P.J.K.; Vahrmeijer, A.L.; Nortier, J.W.R.; Tollenaar, R.A.E.M.; Punt, C. & Gelderblom, H. (2010), Management of isolated nonresectable liver metastases in colorectal cancer patients: a case-control study of isolated hepatic perfusion with melphalan versus systemic chemotherapy, Annals of Oncology 21(8): 1662-1667.
- Iersel, L.B.J. van; Koopman, M.; Velde, C.J.H.V. de; Mol, L.; Meerten, E.L.V.P. van; Hartgrink, H.H.; Kuppen, P.J.K.; Vahrmeijer, A.L.; Nortier, J.W.R.; Tollenaar, R.A.E.M.; Punt, C. & Gelderblom, H. (2010), Management of isolated nonresectable liver metastases in colorectal cancer patients: a case-control study of isolated hepatic perfusion with melphalan versus systemic chemotherapy, Annals of Oncology 21(8): 1662-1667.
- Mieog, J.S.D.; Vahrmeijer, A.L.; Hutteman, M.; Vorst, J.R. van der; Hooff, M.D. van; Dijkstra, J.; Kuppen, P.J.K.; Keijzer, R.; Kaijzel, E.L.; Que, I.; Velde, C.J.H. van de & Lowik, C.W.G.M. (2010), Novel Intraoperative Near-Infrared Fluorescence Camera System for Optical Image-Guided Cancer Surgery, Molecular Imaging 9(4): 223-231.
- Edsparr, K.; Speetjens, F.M.; Mulder-Stapel, A.; Goldfarb, R.H.; Basse, P.H.; Lennernas, B.; Kuppen, P.J.K. & Albertsson, P. (2010), Effects of IL-2 on MMP Expression in Freshly Isolated Human NK Cells and the IL-2-independent NK Cell Line YT, Journal of Immunotherapy 33(5): 475-481.
- Doekhie, F.S.; Mesker, W.E.; Kuppen, P.J.; Leeuwen, G.A. van; Morreau, H.; Bock, G.H. de; Putter, H.; Tanke, H.J.; Velde, C.J. van de & Tollenaar, R.A. (2010), Detailed examination of lymph nodes improves prognostication in colorectal cancer, International Journal of Cancer 126(11): 2644-2652.
- Speetjens, F.M. & Kuppen, P.J.K. (2010), Comment re: Intratumoral Immune Reaction in Human Colorectal Cancer, Cancer Research 70(4): 1741-1741.
- Kruijf, E.M. de; Nes, J.G.H. van; Sajet, A.; Tummers, Q.R.J.G.; Putter, H.; Osanto, S.; Speetjens, F.M.; Smit, V.T.H.B.M.; Liefers, G.J.; Velde, C.J.H. van de & Kuppen, P.J.K. (2010), The Predictive Value of HLA Class I Tumor Cell Expression and Presence of Intratumoral Tregs for Chemotherapy in Patients with Early Breast Cancer, Clinical Cancer Research 16(4): 1272-1280.
- Mesker WE, Liefers GJ, Junggeburt JMC, van Pelt GW, Alberici P, Kuppen PJK, Miranda NF, van Leeuwen KAM, Morreau H & Szuhai K (2009), Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients, Analytical Cellular Pathology / Cellular Oncology 31(3): 169-178.
- Edsparr K, Johansson BR, Goldfarb RH, Basse PH, Nannmark U, Speetjens FM, Kuppen PJK, Lennernas B & Albertsson P (2009), Human NK cell lines migrate differentially in vitro related to matrix interaction and MMP expression, Immunology and Cell Biology 87(6): 489-495.
- Glas AM, Roepman P, Salazar R, Capella G, Moreno V, Westerga J, Kuppen PJ, Simon I, Van't Veer LJ & Tollenaar R (2009), Development and validation of a robust prognostic and predictive signature for colorectal cancer (CRC) patients.
- van Nes JGH, Smit VTHBM, Putter H, Kuppen PJ, Kim SJ, Daito M, Ding J, Shibayama M, Numada S & Gohda K (2009), Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients, British Journal of Cancer 100(3): 494-500.
- Speetjens FM, Kuppen PK, Welters MJP, Essahsah F, van den Brink AMEGV, Lantrua MGK, Valentijn ARPM, Oostendorp J, Fathers LM, Nijman HW, Pander J, Drijfhout JW, Van de Velde CJH, Melief CJM & Van der Burg SH (2009), Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer, Clinical Cancer Research 15(3): 1086-1095.
- de Heer P, Koudijs MM, van de Velde CJH, Aalbers RIJM, Tollenaar RAEM, Putter H, Morreau J, van de Water B & Kuppen PJK (2008), Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation, EJSO - European Journal of Surgical Oncology 34(11).
- de Heer P, Sandel MH, Guertens G, de Boeck G, Koudijs MM, Nagelkerke JF, Junggeburt JMC, de Bruijn EA, van de Velde CJH & Kuppen PJK (2008), Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer, Cancer Chemotherapy and Pharmacology 62(5).
- Speetjens FM, Kuppen PJK, Morreau H & van der Burg SH (2008), Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers, Gastroenterology 135(2).
- Speetjens, F.M.; Lauwen, M.M.; Franken, K.L.; Rhijn, C.M.J.V.; Duikeren, S. van; Bres, S.A.; Velde, C.J.H. van de; Meiief, C.J.M.; Kuppen, P.J.K.; Burg, S.H. van der; Morreau, H. & Offringa, R. (2008), Prediction of the immunogenic potential of frameshift-mutated antigens in microsatellite instable cancer, International Journal of Cancer 123(4).
- van Iersel LBJ, Hoekman EJ, Gelderblom H, Vahrmeijer AL, van Meerten ELV, Tijl FGJ, Hartgrink HH, Kuppen PJK, Nortier JWR, Tollenaar RAEM & van de Velde CJH (2008), Isolated hepatic perfusion with 200 mg melphalan for advanced noncolorectal liver metastases, Annals of Surgical Oncology 15(7).
- van Iersel LBJ, Gelderblom H, Vahrmeijer AL, van Meerten ELV, Tijl FGJ, Putter H, Hartgrink HH, Kuppen PJK, Nortier JWR, Tollenaar RAEM & van de Velde CJH (2008), Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients, Annals of Oncology 19(6).
- Speetjens FM, de Bruin EC, Morreau H, Zeestraten ECM, Putter H, van Krieken JH, van Buren MM, van Velzen M, Dekker-Ensink NG, de Velde CJHV & Kuppen PJK (2008), Clinical impact of HLA class I expression in rectal cancer, Cancer Immunology, Immunotherapy 57(5).
- Speetjens FM, Kuppen PJK, Sandel MH, Menon AG, Burg D, van Velde CJH, Tollenaar RAEM, de Bont HJGM & Nagelkerke JF (2008), Disrupted expression of CXCL5 in colorectal cancer is associated with rapid tumor formation in rats and poor prognosis in patients, Clinical Cancer Research 14(8).
- de Maat MFG, de Velde CJHV, Umetani N, de Heer P, Putter H, van Hoesel AQ, Meijer GA, van Grieken NC, Kuppen PJK, Bilchik AJ, Tollenaar RAEM & Hoon DSB (2007), Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer, Journal of Clinical Oncology 25(31).
- de Heer P, de Bruin EC, Klein-Kranenbarg E, Aalbers RWM, Marijnen CAM, Putter H, de Bont HJ, Nagelkerke JF, van Krieken JHJM, Verspaget HW, van de Velde CJH & Kuppen PJK (2007), Caspase-3 activity predicts local recurrence in rectal cancer, Clinical Cancer Research 13(19).
- van Nimwegen MJ, Verkoeijen S, Kuppen PJK, Velthuis JHL & van de Water B (2007), An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis, Clinical and Experimental Metastasis 24(5).
- van Iersel LBJ, Verlaan MR, Vahrmeijer AL, van Meerten ELV, Tijl FGJ, Sparidans RW, Gelderblom H, Kuppen PJK, Tollenaar RAEM & van de Velde CJH (2007), Hepatic artery infusion of high-dose melphalan at reduced flow during isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: A clinical and pharmacologic evaluation, EJSO - European Journal of Surgical Oncology 33(7).
- Verdegaal EME, Hoogstraten C, Sandel MH, Kuppen PJK, Brink AATP, Claas FHJ, Gorsira MCB, van Roggen JFG & Osanto S (2007), Functional CD8(+) T cells infiltrate into nonsmall cell lung carcinoma, Cancer Immunology, Immunotherapy 56(5).
- de Heer P, Gosens MJEM, de Bruin EC, Dekker-Ensink NG, Putter H, Marijnen CAM, van den Brule AJC, van Krieken JHJM, Rutten HJT, Kuppen PJK & van de Velde CJH (2007), Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy, Clinical Cancer Research 13(10).
- De Heer P, Sandel MH, Speetjens FM, Koudijs MM, Putter H, Ensink GN, Van de Velde CJH & Kuppen PJK (2006), Cutaneous and intra-abdominal abscess formation in rats following radio frequently ablation of liver tumors in combination with celecoxib treatment, In Vivo 20(3).
- Yang Q, Goding S, Hagenaars M, Carlos T, Albertsson P, Kuppen P, Nannmark U, Hokland ME & Basse PH (2006), Morphological appearance, content of extracellular matrix and vascular density of lung metastases predicts permissiveness to infiltration by adoptively transferred natural killer and T cells, Cancer Immunology, Immunotherapy 55(6).
- Doekhie FS, Kuppen PJK, Peeters KCMJ, Mesker WE, van Soest RA, Morreau H, de Velde CJH, Tanke HJ & Tollenaar RAEM (2006), Prognostic relevance of occult tumour cells in lymph nodes in colorectal cancer, EJSO - European Journal of Surgical Oncology 32(3).
- de Noo ME, Tollenaar RAEM, Ozalp A, Kuppen PJK, Bladergroen MR, Eilers PHC & Deelder AM (2005), Reliability of human serum protein profiles generated with C8 magnetic beads assisted MALDI-TOF mass spectrometry, Analytical Chemistry 77(22).
- Doekhie FS, Peeters KCMJ, Kuppen PJK, Mesker WE, Tanke HJ, Morreau H, van de Velde CJH & Tollenaar RAEM (2005), The feasibility and reliability of sentinel node mapping in colorectal cancer, EJSO - European Journal of Surgical Oncology 31(8).
- Doekhie TS, Mesker WE, van Krieken JHJM, Kok NFM, Hartgrink HH, Kranenbarg EK, Putter H, Kuppen PJK, Tanke HJ, Tollenaar RAEM & van de Velde CJH (2005), Clinical relevance of occult tumor cells in lymph nodes from gastric cancer patients, American Journal of Surgical Pathology 29(9).
- Van Vlierberghe RLP, Sandel MH, Prins FA, Van Iersel LBJ, Van De Velde CJH, Tollenaar RAEM & Kuppen PJK (2005), Four-color staining combining fluorescence and brightfield microscopy for simultaneous immune cell phenotyping and localization in tumor tissue sections, Microscopy Research and Technique 67(1).
- Sandel MH, Dadabayev AR, Menon AG, Morreau H, Melief CJM, Offringa R, van der Burg SH, Janssen-van Rhijn CM, Ensink NG, Tollenaar RAEM, van de Velde CJH & Kuppen PJK (2005), Prognostic value of tumor-infiltrating dendritic cells in colorectal cancer: Role of maturation status and intratumoral localization, Clinical Cancer Research 11(7).
- Ohana P, Schachter P, Ayesh B, Mizrahi A, Birman T, Schneider T, Matouk I, Ayesh S, Kuppen PJK, de Groot N, Czerniak A & Hochberg A (2005), Regulatory sequences of H-19 and IGF(2) genes in DNA-based therapy of colorectal rat liver metastases, Journal of Gene Medicine 7(3).
- Sandel MH, Speetjens FM, Menon AG, Albertsson PA, Basse PH, Hokland M, Nagelkerke JF, Tollenaar RAEM, van de Velde CJH & Kuppen PJK (2005), Natural killer cells infiltrating colorectal cancer and MHC class I expression, Molecular Immunology 42(4).
- van Duijnhoven FH, Tollenaar RAEM, Terpstra OT & Kuppen PJK (2005), Locoregional therapies of liver metastases in a rat CC531 coloncarcinoma model results in increased resistance to tumour rechallenge, Clinical and Experimental Metastasis 22(3).
- Timmers M, Vekemans K, Vermijlen D, Asosingh K, Kuppen P, Bouwens L, Wisse E & Braet F (2004), Interactions between rat colon carcinoma cells and Kupffer cells during the onset of hepatic metastasis, International Journal of Cancer 112(5).
- Dadabayev AR, Sandel MH, Menon AG, Morreau H, Melief CJM, Offringa R, van der Burg SH, Janssen-van Rhijn C, Ensink NG, Tollenaar RAEM, van de Velde CJH & Kuppen PJK (2004), Dendritic cells in colorectal cancer correlate with other tumor-infiltrating immune cells, Cancer Immunology, Immunotherapy 53(11).
- Rothbarth J, Tollenaar RAEM, Schellens JHM, Nortier JWR, Kool LJS, Kuppen PJK, Mulder GJ & van de Velde CJH (2004), Isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: recent trends and perspectives, European Journal of Cancer 40(12).
- Gelderman KA, Kuppen PJK, Okada N, Fleuren GJ & Gorter A (2004), Tumor-specific inhibition of membrane-bound complement regulatory protein crry with bispecific monoclonal antibodies prevents tumor outgrowth in a rat colorectal cancer lung metastases model, Cancer Research 64(12).
- Ohana P, Schacter P, Ayesh B, Mizrahi A, Ayesh S, Birman T, Schneider T, Maatouk I, Kuppen PJK, de Groot N, Czerniak A & Hochberg A (2004), The use of the regulatory sequences of H19 and IGF2 genes in DNA based therapy of colorectal rat liver metastases.
- Rothbarth J, Koevoets C, Tollenaar RAEM, Tilby MJ, van de Velde CJH, Mulder GJ & Kuppen PJK (2004), Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo, Biochemical Pharmacology 67(9).
- Menon AG, Janssen CM, Janssen-van Rhijn CM, Morreau H, Putter H, Tollenaar RAEM, van de Velde CJH, Fleuren GJ & Kuppen PJK (2004), Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis, Laboratory Investigation 84(4).
- Noter SL, Rothbarth J, Pijl MEJ, Keunen JEE, Hartgrink HH, Tijl FGJ, Kuppen PJK, van de Velde CJH & Tollenaar RAEM (2004), Isolated hepatic perfusion with high-dose melphalan for the treatment of uveal melanoma metastases confined to the liver, Melanoma Research 14(1).
- van Duijnhoven FH, Aalbers RIJM, Rothbarth J, Terpstra OT & Kuppen PJK (2004), A systemic antitumor immune response prevents outgrowth of lung tumors after i.v. rechallenge but is not able to prevent growth of experimental liver tumors, Clinical and Experimental Metastasis 21(1).
- Menon AG, Tollenaar RAEM, van de Velde CJH, Putter H, Janssen-van Rhijn CM, Keijzer R, Fleuren GJ & Kuppen PJK (2004), p53 and HLA class-I expression are not down-regulated in colorectal cancer liver metastases, Clinical and Experimental Metastasis 21(1).
- van der Eb MM, Geutskens SB, van Kuilenburg ABP, van Lenthe H, van Dierendonck JH, Kuppen PJK, van Ormondt H, van de Velde CJH, Wanders RJA, van Gennip AH & Hoeben RC (2003), Ganciclovir nucteotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene, Journal of Gene Medicine 5(12).
- Rothbarth J, Pijl MEJ, Tollenaar RAEM, Tijl F, Ivancev G, Mulders GJ, Kuppen PJK, van de Velde CJH & Kool LJS (2003), An experimental minimally invasive perfusion technique for the treatment of liver metastases, EJSO - European Journal of Surgical Oncology 29(9).
- Rothbarth J, Pijl MEJ, Vahrmeijer AL, Hartgrink HH, Tijl FGJ, Kuppen PJK, Tollenaar RAEM & van de Velde CJH (2003), Isolated hepatic perfusion with high-dose melphalan for the treatment of colorectal metastasis confined to the liver, British Journal of Surgery 90(11).
- Albertsson PA, Basse PH, Hokland M, Goldfarb RH, Nagelkerke JF, Nannmark U & Kuppen PJK (2003), NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity, Trends in Immunology 24(11).
- Burg, S.H. van der; Menon, A.G.; Redeker, A.; Franken, K.L.M.C.; Drijfhout, J.W.; Tollenaar, R.A.E.M.; Hartgrink, H.H.; Velde, C.J.H. van de; Kuppen, P.J.K.; Melief, C.J.M. & Offringa, R. (2003), Magnitude and polarization of p53-specific T-HELPER immunity in connection to leukocyte infiltration of colorectal tumors, International Journal of Cancer 107(3).
- van Duijnhoven FH, Aalbers RIJM, Rovers JP, Terpstra OT & Kuppen PJK (2003), Immunological aspects of photodynamic therapy of liver tumors in a rat model for colorectal cancer, Photochemistry and Photobiology 78(3).
- Gelderman KA, Hakulinen J, Hagenaars M, Kuppen PJK, Meri S & Gorter A (2003), Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model, Molecular Immunology 40(1).
- Menon AG, Kuppen PJK, van der Burg SH, Offringa R, Bonnet MC, Harinck BIJ, Tollenaar RAEM, Redeker A, Putter H, Moingeon P, Morreau H, Melief CJM & van de Velde CJH (2003), Safety of intravenous administration of a canarypox virus encoding the human wild-type p53 gene in colorectal cancer patients, Cancer Gene Therapy 10(7).
- Menon AG, Fleuren GJ, Alphenaar EA, Jonges LE, van Rhijn CMJ, Ensink NG, Putter H, Tollenaar RAEM, van de Velde CJH & Kuppen PJK (2003), A basal membrane-like structure surrounding tumour nodules may prevent intraepithelial leucocyte infiltration in colorectal cancer, Cancer Immunology, Immunotherapy 52(2).
- Velthuis JHL, de Bont HJGM, Medema JP, Kuppen PJK, Mulder GJ & Nagelkerke JF (2003), Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells, Immunobiology 207(2).
- Velthuis JHL, Stitzinger M, Aalbers RIJM, de Bont HJGM, Mulder GJ, Kuppen PJK & Nagelkerke JF (2003), Rat colon carcinoma cells that survived systemic immune surveillance are less sensitive to NK-cell mediated apoptosis, Clinical and Experimental Metastasis 20(8).
- van Duijnhoven FH, Aalbers RIJM, Rovers JP, Terpstra OT & Kuppen PJK (2003), The immunological consequences of photodynamic treatment of cancer, a literature review, Immunobiology 207(2).
- Menon AG, Morreau H, Tollenaar RAEM, Alphenaar E, van Puijenbroek M, Putter H, Rhijn CMJV, van de Velde CJH, Fleuren GJ & Kuppen PJK (2002), Down-regulation of HLA-A expression correlates with a better prognosis in colorectal cancer patients, Laboratory Investigation 82(12).
- Rohn JL, Zhang YH, Aalbers RIJM, Otto N, den Hertog J, Henriquez NV, van de Velde CJH, Kuppen PJK, Mumberg D, Donner P & Noteborn MHM (2002), A tumor-specific kinase activity regulates the viral death protein apoptin, Journal of Biological Chemistry 277(52).
- Vermijlen D, Luo DZ, Kruhoffer M, Orntoft TF, Kuppen PJK & Wisse E (2002), Is the presence of interleukin-2 receptor alpha in the serum of colorectal liver metastases patients derived from hepatic natural killer cells?, Cancer Immunology, Immunotherapy 51(5).
- van der Burg SH, Menon AG, Redeker A, Bonnet MC, Drijfhout JW, Tollenaar RAEM, van de Velde CJH, Moingeon P, Kuppen PJK, Offringa R & Melief CJM (2002), Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine, Clinical Cancer Research 8(5).
- Gelderman KA, Kuppen PJK, Bruin W, Fleuren GJ & Gorter A (2002), Enhancement of the complement activating capacity of 17-1A mAb to overcome the effect of membrane-bound complement regulatory proteins on colorectal carcinoma, European Journal of Immunology 32(1).
- van der Eb MM, Pietersen AM, Speetjens FM, Kuppen PJK, van de Velde CJH, Noteborn MHM & Hoeben RC (2002), Gene therapy with Apoptin induces regression of xenografted human hepatomas, Cancer Gene Therapy 9(1).
- Menon AG, Kuppen RJK, van der Burg SH, Bonnet MC, Offringa R, Harinck HIJ, Bremers AJA, Tollenaar RAEM, Moingeon P, Melief CJM & van de Velde CJH (2001), Results of a Phase I/II vaccination study in colorectal cancer patients using a canarypox virus encoding the human wild-type p53 gene, Cancer Gene Therapy 8: S24-S24.
- Kuppen PJK, Gorter A, Hagenaars M, Jonges LE, Giezeman-Smits KM, Nagelkerke JF, Fleuren G & van de Velde CJH (2001), Role of NK cells in adoptive immunotherapy of metastatic colorectal cancer in a syngeneic rat model, Immunological Reviews 184.
- Gelderman KA, Bruin W, Kuppen PJK, Fleuren GJ & Gorter A (2001), A syngeneic rat colorectal carcinoma model to study the effect of membrane bound complement regulatory proteins on mAb-immunotherapy, Molecular Immunology 38(2-3): 93-93.
- Blom WM, de Bont HJGM, Meijerman I, Kuppen PJK, van der Meulen H, Mulder GJ & Nagelkerke JF (2001), Remodeling of the actin cytoskeleton of target hepatocytes and NK cells during induction of apoptosis, Cell Motility and the Cytoskeleton 49(2).
- Jonges LE, Nagelkerke JF, Ensink NG, van der Velde EA, Tollenaar RAEM, Fleuren GJ, van de Velde CJH, Morreau H & Kuppen PJK (2001), Caspase-3 activity as a prognostic factor in colorectal carcinoma, Laboratory Investigation 81(5).
- Luo DZ, Vanderkerken K, Chen MC, Vermijlen D, Asosingh K, Willems E, Triantis V, Eizirik DL, Kuppen PJK & Wisse E (2001), Rat hepatic natural killer cells (Pit cells) express mRNA and protein similar to in vitro interleukin-2 activated spleen natural killer cells, Cellular Immunology 210(1).
- Koelemij R, Hagenaars M, Ensink NG, Eggermont AMM, Van De Velde CJH, Fleuren GJ & Kuppen PJK (2001), Administration of BiMAb-retargeted T cells in a rat hepatic metastases colon tumour model results in T-cell tumour infiltration independent of the route of administration, Scandinavian Journal of Immunology 53(3).
- Jonges LE, Albertsson P, Van Vlierberghe RLP, Ensink NG, Johannson BR, Van de Velde CJH, Fleuren GJ, Nannmark U & Kuppen PJK (2001), The phenotypic heterogeneity of human natural killer cells: Presence of at least 48 different subsets in the peripheral blood, Scandinavian Journal of Immunology 53(2).
- Burg, S.H. van der; Cock, K. de; Menon, A.G.; Franken, K.L.M.C.; Palmen, M.; Redeker, A.; Drijfhout, J.W.; Kuppen, P.J.K.; Velde, C.J.H. van de; Erdile, L.; Tollenaar, R.A.E.M.; Melief, C.J.M. & Offringa, R. (2001), Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer, European Journal of Immunology 31(1).
- Kuppen PJK, van der Eb MM, Jonges LE, Hagenaars M, Hokland ME, Nannmlark U, Goldfarb RH, Basse PH, Fleuren GJ, Hoeben RC & van de Velde CJH (2001), Tumor structure and extracellular matrix as a possible barrier for therapeutic approaches using immune cells or adenoviruses in colorectal cancer, Histochemistry and Cell Biology 115(1).
- Bremers AJA, Andreola S, Leo E, Gallino F, Rini F, Lombardo C, Belli F, Kuppen PJK, Parmiani G & Castelli C (2000), T cell responses in colorectal cancer patients: Evidence for class IIHLA-restricted recognition of shared tumor-associated antigens, International Journal of Cancer 88(6).
- Jonges LE, Giezeman-Smits KM, van Vlierberghe RLP, Ensink NG, Hagenaars M, Joly E, Eggermont AMM, van de Velde CJH, Fleuren GJ & Kuppen PJK (2000), NK cells modulate MHC class I expression on tumor cells and their susceptibility to lysis, Immunobiology 202(4).
- Luo DZ, Vermijlen D, Ahishali B, Triantis V, Vanderkerken K, Kuppen PJK & Wisse E (2000), Participation of CD45, NKR-P1A and ANK61 antigen in rat hepatic NK cell (pit cell)-mediated target cell cytotoxicity.
- Geutskens SB, van der Eb MM, Plomp AC, Jonges LE, Cramer SJ, Ensink NG, Kuppen PJK & Hoeben RC (2000), Recombinant adenoviral vectors have adjuvant activity and stimulate T cell responses against tumor cells.
- Bremers AJA, Kuppen PJK & Parmiani G (2000), Tumour immunotherapy: the adjuvant treatment of the 21st century?, EJSO - European Journal of Surgical Oncology 26(4): 418-424.
- Kim MH, Kitson RP, Albertsson P, Nannmark U, Basse PH, Kuppen PJK, Hokland ME & Goldfarb RH (2000), Secreted and membrane-associated matrix metalloproteinases of IL-2-activated NK cells and their inhibitors.
- Vahrmeijer AL, van Dierendonck JH, Keizer HJ, Beijnen JH, Tollenaar RAEM, Pijl MEJ, Marinelli A, Kuppen PJK, van Bockel JH, Mulder GJ & van de Velde CJH (2000), Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver.
- Goldfarb RH, Koelemij R, Muirhead KA, Ohlsson-Wilhelm BM, Gray BD, Kuppen PJK, Basse PH, Al-Atrash G & Kitson RP (2000), A novel drug delivery system using IL-2 activated NK cells and Zyn-linked doxorubicin.
- Albertsson P, Kim MH, Jonges LE, Kitson RP, Kuppen PJK, Johansson BR, Nannmark U & Goldfarb RH (2000), Matrix metalloproteinases of human NK cells.
- Hagenaars M, Ensink NG, Eggermont AMM, van der Velde EA, van de Velde CJH, Fleuren GJ & Kuppen PJK (2000), Endogenous natural killer cells do not play a role in antitumor effects induced by interleukin-2 in a syngeneic rat colon tumor model.
- Hagenaars M, Koelemij R, Ensink NG, van Eendenburg JDH, van Vlierberghe RLP, Eggermont AMM, van de Velde CJH, Fleuren GJ & Kuppen PJK (2000), The development of novel mouse monoclonal antibodies against the CC531 rat colon adenocarcinoma, Clinical and Experimental Metastasis 18(4).
- Hagenaars M, Ensink NG, Basse PH, Hokland M, Nannmark U, Eggermont AMM, van de Velde CJH, Fleuren GJ & Kuppen PJK (2000), The microscopic anatomy of experimental rat CC531 colon tumour metastases: Consequences for immunotherapy?, Clinical and Experimental Metastasis 18(2).
- Koelemij R, Kuppen PJK, van de Velde CJH, Fleuren GJ, Hagenaars M & Eggermont AMM (1999), Bispecific antibodies in cancer therapy, from the laboratory to the clinic, Journal of immunotherapy : official journal of the Society for Biological Therapy 22(6): 514-524.
- Adobati E, Zacchetti A, Perico ME, Cremonesi F, Rasi G, Vallebona PS, Hagenaars M, Kuppen PJK, Pastan I, Panza L, Russo G, Colnaghi MI & Canevari S (1999), Expression profile of saccharide epitope CaMBr1 in normal and neoplastic tissue from dogs, cats, and rats: Implication for the development of human-derived cancer vaccines.
- Luo DZ, Vermijlen D, Vanderkerken K, Kuppen PJK, Seynaeve C, Eddouks M, Baekeland M & Wisse E (1999), Involvement of LFA-1 in hepatic NK cell (pit cell)-mediated cytolysis and apoptosis of colon carcinoma cells, Journal of Hepatology 31(1): 110-116.
- Giezeman-Smits KM, Gorter A, van Vlierberghe RLP, Von Eendenburg JDH, Eggermont AMM, Fleuren GJ & Kuppen PJK (1999), The regulatory role of CD45 on rat NK cells in target cell lysis, Journal of Immunology 163(1): 71-76.
- De Vries MR, Rinkes IHMB, Swaak AJG, Hack CE, Van de Velde CJH, Wiggers T, Tollenaar RAEM, Kuppen PJK & Eggermont AMM (1999), Acute-phase response patterns in isolated hepatic perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan in patients with colorectal liver metastases, European Journal of Clinical Investigation 29(6): 553-560.
- Hokland M, Kjaergaard J, Kuppen PJK, Nannmark U, Agger R, Hokland P & Basse P (1999), Endogenous and adoptively transferred A-NK and T-LAK cells continuously accumulate within murine metastases up to 48h after inoculation, In Vivo 13(3): 199-204.
- Hendriks JMH, Van Schil PEY, Van Oosterom AAT, Kuppen PJK, Van Marck E & Eyskens E (1999), Isolated lung perfusion with melphalan prolongs survival in a rat model of metastatic pulmonary adenocarcinoma.
- Pietersen AM, van der Eb MM, Rademaker HJ, van den Wollenberg DJM, Rabelink MJWE, Kuppen PJK, van Dierendonck JH, van Ormondt H, Masman D, van de Velde CJH, van der Eb AJ, Hoeben RC & Noteborn MHM (1999), Specific tumor-cell killing with adenovirus vectors containing the apoptin gene, Gene Therapy 6(5): 882-892.
- Blom WM, De Bont HJGM, Meijerman I, Kuppen PJK, Mulder GJ & Nagelkerke JF (1999), Interleukin-2-activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes, Hepatology 29(3): 785-792.
- Hagenaars M, Ensink NG, Jonges LE, Chambers WH, Eggermont AMM, van de Velde CJH, Fleuren GJ & Kuppen PJK (1999), The development of a bi-specific anti-CD 161AxAnti-tumor antibody for rat NK cell targeting, Immunobiology 200(1): 31-48.
- Hagenaars M, Zwaveling S, Kuppen PJK, Ensink NG, Eggermont AMM, Hokland ME, Basse PH, van de Velde CJH, Fleuren GJ & Nannmark U (1998), Characteristics of tumor infiltration by adoptively transferred and endogenous natural-killer cells in a syngeneic rat model: Implications for the mechanism behind anti-tumor responses, International Journal of Cancer 78(6): 783-789.
- Vahrmeijer AL, Van der Eb MM, Van Dierendonck JH, Kuppen PJK & van de Velde CJH (1998), Delivery of anticancer drugs via isolated hepatic perfusion: A promising strategy in the treatment of irresectable liver metastases?, Seminars in Surgical Oncology 14(3): 262-268.
- Giezeman-Smits KM, Jonges LE, Chambers WH, Brisette-Storkus CS, Van Vlierberghe RLP, Van Eendenburg JDH, Eggermont AMM, Fleuren GJ & Kuppen PJK (1998), Novel monoclonal antibodies against membrane structures that are preferentially expressed on IL-2-activated rat NK cells, Journal of Leukocyte Biology 63(2): 209-215.
- Hagenaars M, Ensink NG, Koelemij R, Basse PH, Eggermont AMM, van de Velde CJH, Fleuren GJ & Kuppen PJK (1998), Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration, International Journal of Cancer 75(2): 233-238.
- GiezemanSmits KM, Gorter A, Nagelkerke JF, vanVlierberghe RLP, vanEendenburg J, Eggermont AMM, Fleuren GJ & Kuppen PJK (1997), Characterization of three new membrane structures on rat NK cells which are involved in activation of the lytic machinery, Immunobiology 197(5): 429-443.
- Kuppen PJK, Jonges LE, vandeVelde CJH, Vahrmeijer AL, Tollenaar RAEM, Rinkes IHMB & Eggermont AMM (1997), Liver and tumour tissue concentrations of TNF-alpha in cancer patients treated with TNF-alpha and melphalan by isolated liver perfusion, British Journal of Cancer 75(10): 1497-1500.
- Ras E, vanderBurg SH, Zegveld ST, Brandt RMP, Kuppen PJK, Offringa R, Warnarr SO, vandeVelde CJH & Melief CJM (1997), Identification of potential HLA-A*0201 restricted CTL epitopes derived from the epithelial cell adhesion molecule (Ep-CAM) and the carcinoembryonic antigen (CEA), Human Immunology 53(1): 81-89.
- Nannmark U, Basse P, Johansson BR, Kuppen P, Kjaergaard J & Hokland M (1996), Morphological studies of effector cell-microvessel interactions in adoptive immunotherapy in tumor-bearing animals, Natural Immunity 15(2-3): 78-86.
- Luo DZ, Vanderkerken K, Bouwens L, Kuppen PJK, Baekeland M, Seynaeve C & Wisse E (1996), The role of adhesion molecules in the recruitment of hepatic natural killer cells (pit cells) in rat liver, Hepatology 24(6): 1475-1480.
- GiezemanSmith KM, Kuppen PJK, Ensink NG, Eggermont AMM, Stals F, Wonigeit K & Fleuren GJ (1996), The role of MHC class I expression in rat NK cell-mediated lysis of syngeneic tumor cells and virus-infected cells, Immunobiology 195(3): 286-299.
- BREMERS AJA, VANDERBURG SH, KUPPEN PJK, KAST WM, VANDEVELDE CJH & MELIEF CJM (1995), THE USE OF EPSTEIN-BARR VIRUS-TRANSFORMED B-LYMPHOCYTE CELL-LINES IN A PEPTIDE-RECONSTITUTION ASSAY - IDENTIFICATION OF CEA-RELATED HLA-A-ASTERISK-O301-RESTRICTED POTENTIAL CYTOTOXIC T-LYMPHOCYTE EPITOPES, Journal of immunotherapy : official journal of the Society for Biological Therapy 18(2): 77-85.
- LUO DZ, VANDERKERKEN K, BOUWENS L, KUPPEN PJK, CRABBE E & WISSE E (1995), THE NUMBER AND DISTRIBUTION OF HEPATIC NATURAL-KILLER-CELLS (PIT CELLS) IN NORMAL RAT-LIVER - AN IMMUNOHISTOCHEMICAL STUDY, Hepatology 21(6): 1690-1694.
- FLEUREN GJ, GORTER A, KUPPEN PJK, LITVINOV S & WARNAAR SO (1995), TUMOR HETEROGENEITY AND IMMUNOTHERAPY OF CANCER, Immunological Reviews 145: 91-122.
- VANDERKERKEN K, BOUWENS L, KUPPEN P, DENEVE W, VANDENBERG K, BAEKELAND M & WISSE E (1994), EFFECT OF IRRADIATION ON HEPATIC NATURAL-KILLER-CELLS, Hepatology 19(6): 1453-1458.
- KUPPEN PJK, BASSE PH, GOLDFARB RH, VANDEVELDE CJH, FLEUREN GJ & EGGERMONT AMM (1994), THE INFILTRATION OF EXPERIMENTALLY-INDUCED LUNG METASTASES OF COLON-CARCINOMA CC531 BY ADOPTIVELY TRANSFERRED INTERLEUKIN-2-ACTIVATED NATURAL-KILLER-CELLS IN WAG RATS, International Journal of Cancer 56(4): 574-579.
- SMITS KM, KUPPEN PJK, EGGERMONT AMM, TAMATANI T, MIYASAKA M & FLEUREN CJ (1994), RAT INTERLEUKIN-2-ACTIVATED NATURAL-KILLER (A-NK) CELL-MEDIATED LYSIS IS DETERMINED BY THE PRESENCE OF CD18 ON A-NK CELLS AND THE ABSENCE OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ON TARGET-CELLS, European Journal of Immunology 24(1): 171-175.
- KUPPEN PJK, EGGERMONT AMM, QUAK RBWM, MARINELLI A, VANDEVELDE CJH & FLEUREN GJ (1994), SOLUBLE FACTORS PRODUCED BY MACROPHAGES MONOCYTES INHIBIT LYMPHOKINE-ACTIVATED KILLER ACTIVITY IN RAT SPLENOCYTE CULTURES, Cancer Immunology, Immunotherapy 38(1): 61-67.
- SMITS KM, KUPPEN PJK, LAZEROMS SPG, EGGERMONT AMM & FLEUREN GJ (1993), MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I EXPRESSION AND SENSITIVITY TO INTERLEUKIN-2 ACTIVATED NK CELL-MEDIATED LYSIS OF ADENOVIRUS-TRANSFORMED BABY RAT-KIDNEY CELLS, Transplantation Proceedings 25(5): 2804-2805.
- SMITS KM, KUPPEN PJK, EGGERMONT AMM & FLEUREN GJ (1993), PREINCUBATION OF TUMOR-CELLS WITH THE ANTI-(MHC) CLASS-I ANTIBODY OX18 ENHANCES TUMOR-CELL LYSIS BY INTERLEUKIN-2-ACTIVATED NK CELLS, Transplantation Proceedings 25(5): 2806-2807.
- KUPPEN PJK, EGGERMONT AMM, SMITS KM, VANEENDENBURG JDH, LAZEROMS SPG, VANDEVELDE CJH & FLEUREN GJ (1993), THE DEVELOPMENT AND PURIFICATION OF A BISPECIFIC ANTIBODY FOR LYMPHOKINE-ACTIVATED KILLER-CELL TARGETING AGAINST THE RAT COLON-CARCINOMA CC531, Cancer Immunology, Immunotherapy 36(6): 403-408.
- THOMAS C, NIJENHUIS AM, TIMENS W, KUPPEN PJK, DAEMEN T & SCHERPHOF GL (1993), LIVER METASTASIS MODEL OF COLON-CANCER IN THE RAT - IMMUNOHISTOCHEMICAL CHARACTERIZATION, Invasion and Metastasis 13(2): 102-112.
- VANDENBERGBAKKER CAM, HAGEMEIJER A, FRANKENPOSTMA EM, SMIT VTHBM, KUPPEN PJK, CLAASEN HHV, CORNELISSE CJ & SCHRIER PI (1993), ESTABLISHMENT AND CHARACTERIZATION OF 7 OVARIAN-CARCINOMA CELL-LINES AND ONE GRANULOSA TUMOR-CELL LINE - GROWTH FEATURES AND CYTOGENETICS, International Journal of Cancer 53(4): 613-620.
- KUPPEN PJK, MARINELLI A, CAMPS JAJ, PAUWELS EKJ, VANDEVELDE CJH, FLEUREN GJ & EGGERMONT AMM (1992), BIODISTRIBUTION OF LYMPHOKINE-ACTIVATED KILLER (LAK) CELLS IN WAG RATS AFTER HEPATIC-ARTERY OR JUGULAR-VEIN INFUSION, International Journal of Cancer 52(2): 266-270.
- MARINELLI A, PONS DHA, VREEKEN JAC, NAGESSER SK, KUPPEN PJK, TJADEN UR & VANDEVELDE CJH (1991), HIGH MITOMYCIN-C CONCENTRATION IN TUMOR-TISSUE CAN BE ACHIEVED BY ISOLATED LIVER PERFUSION IN RATS, Cancer Chemotherapy and Pharmacology 28(2): 109-114.
- MARINELLI A, VANDIERENDONCK JH, VANBRAKEL GM, IRTH H, KUPPEN PJK, TJADEN UR & VANDEVELDE CJH (1991), INCREASING THE EFFECTIVE CONCENTRATION OF MELPHALAN IN EXPERIMENTAL RAT-LIVER TUMORS - COMPARISON OF ISOLATED LIVER PERFUSION AND HEPATIC-ARTERY INFUSION, British Journal of Cancer 64(6): 1069-1075.
- MARINELLI A, DIJKSTRA FR, VANDIERENDONCK JH, KUPPEN PJK, CORNELISSE CJ & VANDEVELDE CJH (1991), EFFECTIVENESS OF ISOLATED LIVER PERFUSION WITH MITOMYCIN-C IN THE TREATMENT OF LIVER-TUMORS OF RAT COLORECTAL-CANCER, British Journal of Cancer 64(1): 74-78.
- KUPPEN PJK, EGGERMONT AMM, MARINELLI A, DEHEER E, VANDEVELDE CJH & FLEUREN GJ (1991), INDUCTION OF LYMPHOKINE-ACTIVATED KILLER ACTIVITY IN RAT SPLENOCYTE CULTURES - THE IMPORTANCE OF 2-MERCAPTOETHANOL AND INDOMETHACIN, Cancer Immunology, Immunotherapy 33(1): 28-32.
- MARINELLI A, VANDEVELDE CJH, KUPPEN PJK, FRANKEN HCM, SOUVERIJN JHM & EGGERMONT AMM (1990), A COMPARATIVE-STUDY OF ISOLATED LIVER PERFUSION VERSUS HEPATIC-ARTERY INFUSION WITH MITOMYCIN-C IN RATS, British Journal of Cancer 62(6): 891-896.
- BOUWENS L, MARINELLI A, KUPPEN PJK, EGGERMONT AMM, VANDEVELDE CJH & WISSE E (1990), ELECTRON-MICROSCOPIC OBSERVATIONS ON THE ACCUMULATION OF LARGE ANTIGRANULOCYTES LYMPHOCYTES (PIT CELLS) AND KUPFFER CELLS IN THE LIVER OF RATS TREATED WITH CONTINUOUS INFUSION OF INTERLEUKIN-2, Hepatology 12(6): 1365-1370.
- KUPPEN PJK, SCHUITEMAKER H, VANTVEER LJ, VANOOSTEROM AT, SCHRIER PI & DEBRUIJN EA (1988), CIS-DIAMMINEDICHLOROPLATINUM(II)-RESISTANT SUBLINES DERIVED FROM 2 HUMAN OVARIAN TUMOR-CELL LINES, Pharmaceutisch weekblad. Scientific edition 10(6): 296-296.
- KUPPEN PJK, SCHUITEMAKER H, VANTVEER LJ, DEBRUIJN EA, VANOOSTEROM AT & SCHRIER PI (1988), CIS-DIAMMINEDICHLOROPLATINUM(II)-RESISTANT SUBLINES DERIVED FROM 2 HUMAN OVARIAN TUMOR-CELL LINES, Cancer Research 48(12): 3355-3359.
- SLEE PHTJ, DEBRUIJN EA, LEEFLANG P, KUPPEN PJK, VANDENBERG L & VANOOSTEROM AT (1986), VARIATIONS IN EXPOSURE TO MITOMYCIN-C IN AN INVITRO COLONY-FORMING ASSAY, British Journal of Cancer 54(6): 951-955.
- DEBRUIJN EA, VANOOSTEROM AT, KUPPEN PJK, JOL C, TJADEN UR, TRIMBOS JB, RUNHAAR EA & NOOIJ MA (1986), THE TREATMENT OF RESISTANT OVARIAN-CANCER BY INTRACAVITARY CHEMOTHERAPY, Pharmaceutisch weekblad. Scientific edition 8(2): 160-160.