Mirko Signorelli
Assistant Professor
- Name
- Dr. M. Signorelli
- Telephone
- +31 71 527 7131
- m.signorelli@math.leidenuniv.nl
See also
Assistant Professor
- Science
- Mathematisch Instituut
- Mathematisch Instituut
- Gomon D., Sijmons J., Putter H., Dekker J.W., Tollenaar R., Wouters M., Tanis P., Fiocco M. & Signorelli M. (2024), Inspecting the quality of care: a comparison of CUSUM methods for inter hospital performance, Health Services and Outcomes Research Methodology : .
- Gomon D., Putter H., Fiocco M. & Signorelli M. (2024), Dynamic prediction of survival using multivariate functional principal component analysis: a strict landmarking approach, Statistical Methods in Medical Research 33(2): 256-272.
- Signorelli M., Tsonka R., Aartsma-Rus A. & Spitali P. (2023), Multiomic characterization of disease progression in mice lacking dystrophin, PLoS ONE 18: e0283869.
- Velde N.M. van de, Koeks Z., Signorelli M., Verwey N., Overzier M., Bakker J.A., Sajeev G., Signorovitch J., Ricotti V., Verschuren J., Brown K., Spitali P. & Niks E.H. (2023), Longitudinal assessment of creatine kinase, creatine/creatinine ratio and myostatin as monitoring biomarkers in Becker muscular dystrophy, Neurology 100(9): e975-e984.
- Johansson C., Hunt H., Signorelli M., Edfors F., Hober A., Svensson A., Tegel H., Forststrom B., Aartsma-Rus A., Niks E., Spitali P., Uhlén M. & Szigyarto C.A. (2023), Orthogonal proteomics methods warrant the development of Duchenne muscular dystrophy biomarkers, Clinical Proteomics 20: 23.
- Signorelli M. & Cutillo L. (2022), On community structure validation in real networks, Computational Statistics 37: 1165-1183.
- Signorelli M., Ebrahimpoor M., Veth O., Hettne K., Verwey N., García-Rodríguez R., Tanganyika-deWinter C.L., Hernandez L.B.L., Cedillo R.E., Díaz B.G., Magnussen O.T., Mei H., Tsonaka R., Aartsma-Rus A. & Spitali P. (2021), Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients, EMBO Molecular Medicine 13(4): e13328.
- Signorelli M., Spitali P., Szigyarto C.A. & Tsonaka R. (2021), Penalized regression calibration: a method for the prediction of survival outcomes using complex longitudinal and high‐dimensional data, Statistics in Medicine 40(27): 6178-6196.
- Koeks Z., Janson A.A., Beekman C., Signorelli M., Duyvenvoorde H.A. van, Bergen J.C. van den, Hooijmans M.T., Alleman I., Hegeman I.M., Verschuuren J.J.G.M., Deutekom J.C. van, Spitali P., Datson N.a. & Niks E.H. (2021), Low dystrophin variability between muscles and stable expression over time in Becker muscular dystrophy using capillary Western immunoassay, Scientific Reports 11: 5952.
- Signorelli M., Spitali P., Szigvarto C.A. & Tsonoka R. (2021), Penalized regression calibration: a method for the prediction of survival outcomes using complex longitudinal and high‐dimensional data, Statistics in Medicine 40(27): 6178-6196.
- Signorelli M., Ayoglu B., Johansson C., Lochmüller H., Straub V., Muntoni F., Niks E., Tsonaka R., Persson A., Aartsma-Rus An., Nilsson P., Al-Khalili Szigyarto C. & Spitali P. (2020), Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy, Journal of Cachexia, Sarcopenia and Muscle 11(2): 505-517.
- Tsonaka R., Signorelli M., Sabir E., Seyer A., Hettne K., Aartsma-Rus A. & Spitali P. (2020), Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models, Human Molecular Genetics 29(5): 745-755.
- Signorelli M., Spitali P. & Tsonaka R. (2020), Poisson–Tweedie mixed-effects model: a flexible approach for the analysis of longitudinal RNA-seq data, Statistical Modelling 21(6): 520-545.
- Previtali S.C., Gidaro T., Díaz-Manera J., Zambon A., Carnesecchi S., Roux-Lombard P., Spitali P., Signorelli M., Al-Khalili Szigyarto C., Johansson C., Gray J., Labolle D., Porte-Thomé F., Pitchforth J., Domingos J. & Muntoni F. (2020), Rimeporide as a first- in-class NHE-1 inhibitor: results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy, Pharmacological Research 159: 104999.
- Strandberg K., Ayoglu B., Roos A., Reza M., Niks E., Signorelli M., Fasterius E., Pontén F., Lochmüller H., Domingos J., Ala P., Muntoni F., Aartsma-Rus A., Spitali P., Nilsson P. & Szigyarto C.A. (2020), Blood-derived biomarkers correlate with clinical progression in Duchenne muscular dystrophy, Journal of Neuromuscular Diseases 7(3): 231-246.
- Signorelli M., Mason A.G., Mul K., Evangelista T., Mei H., Voermans N., Tapscott S.J., Tsonaka R., Engelen B.G.M. van, Maarel S.M. van der & Spitali P. (2020), Evaluation of blood gene expression levels in facioscapulohumeral muscular dystrophy patients, Scientific Reports 10(1): 17547.
- Signorelli M. & Wit E.C. (2019), Model-based clustering for populations of networks, Statistical Modelling 20(1): 9-29.