Hermelijn Smits
Professor Host-commensal Interactions and Immune Modulation
- Name
- Prof.dr. H.H. Smits
- Telephone
- +31 71 526 5070
- h.h.smits@lumc.nl
- ORCID iD
- 0000-0001-9279-2890
Professor Host-commensal Interactions and Immune Modulation
- Faculteit Geneeskunde
- Divisie 2
- Infectious Diseases
- Parasitologie
- Costain, A.H.; Phythian-Adams, A.T.; Colombo, S.A.P.; Marley, A.K.; Owusu, C.; Cook, P.C.; Brown, S.L.; Webb, L.M.; Lundie, R.J.; Borger, J.G.; Smits, H.H.; Berriman, M. & Macdonald, A.S. (2023), Dynamics of host immune response development during Schistosoma mansoni infection (vol 13, 906338, 2022), Frontiers in Immunology 14.
- Kuipers, M.E.; Nguyen, D.L.; Diepen, A. van; Mes, L.; Bos, E.; Koning, R.I.; Nolte-'t Hoen, E.N.M.; Smits, H.H. & Hokke, C.H. (2023), Life stage-specific glycosylation of extracellular vesicles from Schistosoma mansoni schistosomula and adult worms drives differential interaction with C-type lectin receptors DC-SIGN and MGL, Frontiers in Molecular Biosciences 10.
- Schrumpf, J.A.; Ninaber, D.K.; Müller, C.; Rankl, B.; Mutius, E. von; Smits, H.H. & Hiemstra, P.S. (2023), Farm dust reduces mucin production in rhinovirus-infected primary bronchial epithelial cells, Pediatric Allergy and Immunology 34(8).
- Dorst, M.M.A.R. van; Pyuza, J.J.; Nkurunungi, G.; Kullaya, V.I.; Smits, H.H.; Hogendoorn, P.C.W.; Wammes, L.J.; Everts, B.; Elliott, A.M.; Jochems, S.P. & Yazdanbakhsh, M. (2023), Immunological factors linked to geographical variation in vaccine responses, Nature Reviews Immunology.
- Voskamp, A.L.; Tak, T.; Gerdes, M.L.; Menafra, R.; Duijster, E.; Kielbasa, S.M.; Kormelink, T.G.; Stam, K.A.; Hengel, O.R.J. van; Jong, N.W. de; Hendriks, R.W.; Kloet, S.L.; Yazdanbakhsh, M.; Jong, E.C. de; Wijk, R.G. van & Smits, H.H. (2023), Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge, Journal of Experimental Medicine 220(9).
- Chayé, M.A.M.; Gasan, T.A.; Ozir-Fazalalikhan, A.; Scheenstra, M.R.; Zawistowska-Deniziak, A.; Hengel, O.R.J. van; Gentenaar, M.; Manurung, M.D.; Harvey, M.R.; Codée, J.D.C.; Chiodo, F.; Heijke, A.M.; Kalinowska, A.; Diepen, A. van; Hensbergen, P.J.; Yazdanbakhsh, M.; Guigas, B.; Hokke, C.H. & Smits, H.H. (2023), Schistosoma mansoni egg-derived thioredoxin and Sm14 drive the development of IL-10 producing regulatory B cells, PLoS Neglected Tropical Diseases 17(6).
- White, R.; Sotillo, J.; Ancarola, M.E.; Borup, A.; Boysen, A.T.; Brindley, P.J.; Buzas, E.I.; Cavallero, S.; Chaiyadet, S.; Chalmers, I.W.; Cucher, M.A.; Dagenais, M.; Davis, C.N.; Devaney, E.; Duque-Correa, M.A.; Eichenberger, R.M.; Fontenla, S.; Gasan, T.A.; Hokke, C.H.; Kosanovic, M.; Kuipers, M.E.; Laha, T.; Loukas, A.; Maizels, R.M.; Marcilla, A.; Mazanec, H.; Morphew, R.M.; Neophytou, K.; Nguyen, L.T.; Nolte-'t Hoen, E.; Povelones, M.; Robinson, M.W.; Rojas, A.; Schabussova, I.; Smits, H.H.; Sungpradit, S.; Tritten, L.; Whitehead, B.; Zakeri, A.; Nejsum, P.; Buck, A.H. & Hoffmann, K.F. (2023), Special considerations for studies of extracellular vesicles from parasitic helminths, Journal of Extracellular Vesicles 12(1).
- Roukens, A.H.E.; Pothast, C.R.; Konig, M.; Huisman, W.; Dalebout, T.; Tak, T.; Azimi, S.; Kruize, Y.; Hagedoorn, R.S.; Zlei, M.; Staal, F.J.T.; Bie, F.J. de; Dongen, J.J.M. van; Arbous, S.M.; Zhang, J.L.H.; Verheij, M.; Prins, C.; Does, A.M. van der; Hiemstra, P.S.; Vries, J.J.C. de; Janse, J.J.; Roestenberg, M.; Myeni, S.K.; Kikkert, M.; Yazdanbakhsh, M.; Heemskerk, M.H.M.; Smits, H.H.; Jochems, S.P.; Collaboration BEAT-COVID Grp & Collaboration COVID-19 LUMC Grp (2022), Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8(+) T cell responses following COVID-19, Nature Immunology 23.
- Zawistowska-Deniziak, A.; Lambooij, J.M.; Kalinowska, A.; Patente, T.A.; Lapinski, M.; Zande, H.J.P. van der; Basalaj, K.; Korne, C.M. de; Chaye, M.A.M.; Gasan, T.A.; Norbury, L.J.; Giera, M.; Zaldumbide, A.; Smits, H.H. & Guigas, B. (2022), Fasciola hepatica Fatty Acid Binding Protein 1 Modulates T cell polarization by promoting dendritic cell thrombospondin-1 Secretion without affecting metabolic homeostasis in obese mice, Frontiers in Immunology 13.
- Costain, A.H.; Phythian-Adams, A.T.; Colombo, S.A.P.; Marley, A.K.; Owusu, C.; Cook, P.C.; Brown, S.L.; Webb, L.M.; Lundie, R.J.; Smits, H.H.; Berriman, M. & MacDonald, A.S. (2022), Dynamics of host immune response development during Schistosoma mansoni infection, Frontiers in Immunology 13.
- Kuipers, M.E.; Koning, R.I.; Bos, E.; Hokke, C.H.; Smits, H.H. & Nolte-'t Hoen, E.N.M. (2022), Optimized protocol for the isolation of extracellular vesicles from the parasitic worm Schistosoma mansoni with improved purity, concentration, and yield, Journal of Immunology Research 2022.
- Mathilde A M Chayé, Chiara Tontini, Arifa Ozir-Fazalalikhan, Astrid L Voskamp & Hermelijn H Smits (2021), Use of Toll-Like Receptor (TLR) Ligation to Characterize Human Regulatory B-Cells Subsets.
- Jochems, S.P.; Ferreira, D.M. & Smits, H.H. (2021), Microbiota and compartment matter in the COVID-19 response, Nature Immunology 22(11): 1350-1352.
- Wijk, R.G. van & Smits, H.H. (2021), Heterogeneity in allergic rhinitis: explained by inducible mechanistic traits?, Journal of Allergy and Clinical Immunology 148(2): 358-360.
- Schrumpf, J.A.; Tham, M.; Ninaber, D.K.; Mutius, E. von; Smits, H.H. & Hiemstra, P.S. (2021), Farm dust exposure decreases gene expression of epithelial alarmins in primary bronchial epithelial cells, European Respiratory Journal 58.
- Winkel, B.M.F.; Pelgrom, L.R.; Schuijlenburg, R. van; Baalbergen, E.; Ganesh, M.S.; Gerritsma, H.; Korne, C.M. de; Duszenko, N.; Langenberg, M.C.C.; Chevalley-Maurel, S.C.; Smits, H.H.; Jong, E.C. de; Everts, B.; Franke-Fayard, B. & Roestenberg, M. (2020), Plasmodium sporozoites induce regulatory macrophages, PLoS Pathogens 16(9).
- Kuipers, M.E.; Nolte-'t Hoen, E.N.M.; Ham, A.J. van der; Ozir-Fazalalikhan, A.; Nguyen, D.L.; Korne, C.M. de; Koning, R.I.; Tomes, J.J.; Hoffmann, K.F.; Smits, H.H. & Hokke, C.H. (2020), DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells, Journal of Extracellular Vesicles 9(1).
- Schrumpf, J.A.; Khedoe, P.P.S.I.; Riet, S. van; Ninaber, D.K.; Mutius, E. von; Smits, H.H. & Hiemstra, P.S. (2020), Epithelial wound repair is increased by farm dust in a co-culture model of airway epithelial cells and macrophages, European Respiratory Journal 56.
- Mutius, E. von & Smits, H.H. (2020), Primary prevention of asthma: from risk and protective factors to targeted strategies for prevention, The Lancet 396(10254): 854-866.
- Labuda, L.A.; Adegnika, A.A.; Rosa, B.A.; Martin, J.; Ateba-Ngoa, U.; Amoah, A.S.; Lima, H.M.; Meurs, L.; Mbow, M.; Manurung, M.D.; Zinsou, J.F.; Smits, H.H.; Kremsner, P.G.; Mitreva, M. & Yazdanbakhsh, M. (2020), A praziquantel treatment study of immune and transcriptome profiles in Schistosoma haematobium-infected Gabonese schoolchildren, The Journal of Infectious Diseases 222(12): 2103-2113.
- Voskamp, A.L.; Kormelink, T.G.; Wijk, R.G. van; Hiemstra, P.S.; Taube, C.; Jong, E.C. de & Smits, H.H. (2020), Modulating local airway immune responses to treat allergic asthma: lessons from experimental models and human studies, Seminars in Immunopathology 42(1): 95-110.
- Gosens, R.; Hiemstra, P.S.; Adcock, I.M.; Bracke, K.R.; Dickson, R.P.; Hansbro, P.M.; Krauss-Etschmann, S.; Smits, H.H.; Stassen, F.R.M. & Bartel, S. (2020), Host-microbe cross-talk in the lung microenvironment, European Respiratory Journal 56(2).
- Ruszczynski, M.; Ambrozej, D.; Adamiec, A.; Ryczaj, K.; Elenius, V.; Cavkaytar, O.; Maggina, P.; Makrinioti, H.; Papadopoulos, N.; Hedlin, G.; Konradsen, J.R.; Schaub, B.; Smits, H.H.; Jartti, T. & Feleszko, W. (2020), Preschool wheezing and asthma in children, Pediatric Allergy and Immunology 31(1).
- Kuipers, M.E.; Nolte-'t Hoen, E.N.M.; Ham, A.J. van der; Ozir-Fazalalikhan, A.; Nguyen, D.L.; Korne, C.M. de; Koning, R.I.; Tomes, J.J.; Hoffmann, K.F.; Smits, H.H. & Hokke, C.H. (2020), DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells, Journal of Extracellular Vesicles 9(1).
- Tontini, C.; Voskamp, A.L.; Ozir-Fazalalikhan, A.; Kruize, Y.C.; Busilacchi, E.M.; Tak, T.; Martina, E.; Corsi, A.; Zawistowska-Deniziak, A.; Offidani, A.M.; Bilo, M.B.; Costantini, A.; Antonicelli, L. & Smits, H.H. (2020), Immunological differences among chronic spontaneous urticaria patient subgroups according to omalizumab end-treatment outcome, Allergy 75: 291-292.
- Jartti, T.; Smits, H.H.; Bonnelykke, K.; Cavkaytar, O.; Elenius, V.; Konradsen, J.R.; Makrinioti, H.; Stokholm, J.; Hedlin, G.; Papadopoulos, N.; Ruszczynski, M.; Ryczaj, K.; Schaub, B.; Schwarze, J. & Feleszko, W. (2020), Correspondence to "Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments".
- Ubags, N.D.J.; Alcazar, M.A.A.; Kallapur, S.G.; Knapp, S.; Lanone, S.; Lloyd, C.M.; Morty, R.E.; Pattaroni, C.; Reynaert, N.L.; Rottier, R.J.; Smits, H.H.; Piters, W.A.A.D.; Strickland, D.H. & Collins, J.J.P. (2020), Early origins of lung disease: towards an interdisciplinary approach, European Respiratory Review 29(157).
- Langenberg, M.C.C.; Hoogerwerf, M.A.; Janse, J.J.; Lieshout, L. van; Corstjens, P.L.A.M.; Roestenberg, M.; Dam, G.J. van; Diepen, A. van; Dood, C.J. de; Feijt, C.; Ganesh, M.S.; Gerritsma, H.; Hardeman, G.; Hokke, C.H.; Koopman, J.P.R.; Kos-van Oosterhoud, J.; Kruize, Y.C.M.; Meij, P.; Ozir-Fazalalikhan, A.; Schuijlenburg, R. van; Smits, H.H.; Verbeek-Menken, P.H.; Visser, L.G.; Vries, J.J.C. de; Winkel, B.M.F.; Yazdanbakhsh, M. & CoHSI Clinical Trial Team (2019), Katayama Syndrome Without Schistosoma mansoni Eggs, Annals of Internal Medicine 170(10): 732-+.
- Katiraei, S.; Vries, M.R. de; Costain, A.H.; Thiem, K.; Hoving, L.R.; Diepen, J.A. van; Smits, H.H.; Bouter, K.E.; Rensen, P.C.N.; Quax, P.H.A.; Nieuwdorp, M.; Netea, M.C.; Vos, W.M. de; Cani, P.D.; Belzer, C.; Dijk, K.W. van; Berbee, J.F.P. & Harmelen, V. van (2019), Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice, Molecular Nutrition and Food Research.
- Jochems, S.P.; Ruiter, K. de; Solorzano, C.; Voskamp, A.; Mitsi, E.; Nikolaou, E.; Carniel, B.F.; Pojar, S.; German, E.L.; Reine, J.; Soares-Schanoski, A.; Hill, H.; Robinson, R.; Hyder-Wright, A.D.; Weight, C.M.; Durrenberger, P.F.; Heyderman, R.S.; Gordon, S.B.; Smits, H.H.; Urban, B.C.; Rylance, J.; Collins, A.M.; Wilkie, M.D.; Lazarova, L.; Leong, S.C.; Yazdanbakhsh, M. & Ferreira, D.M. (2019), Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization, Journal of Clinical Investigation 129(10): 4523-4538.
- Costain, A.H.; MacDonald, A.S. & Smits, H.H. (2019), Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses (vol 9, 3042, 2018), Frontiers in Immunology 10.
- Jartti, T.; Smits, H.H.; Bonnelykke, K.; Bircan, O.; Elenius, V.; Konradsen, J.R.; Maggina, P.; Makrinioti, H.; Stokholm, J.; Hedlin, G.; Papadopoulos, N.; Ruszczynski, M.; Ryczaj, K.; Schaub, B.; Schwarze, J.; Skevaki, C.; Stenberg-Hammar, K.; Feleszko, W. & EAACI Task Force Clinical Practice (2019), Bronchiolitis needs a revisit: Distinguishing between virus entities and their treatments, Allergy 74(1): 40-52.
- Wijck, Y. van; John-Schuster, G.; Schadewijk, A. van; Oever, R.L. van den; Obieglo, K.; Hiemstra, P.S.; Muller, A.; Smits, H.H. & Taube, C. (2019), Extract of Helicobacter pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure, International Archives of Allergy and Immunology 180(1): 1-9.
- Adamiec, A.; Ambrozej, D.; Ryczaj, K.; Ruszczynski, M.; Elenius, V.; Cavkaytar, O.; Hedlin, G.; Konradsen, J.R.; Maggina, P.; Makrinioti, H.; Papadopoulos, N.; Schaub, B.; Schwarze, J.; Skevaki, C.; Smits, H.H.; Jartti, T.; Feleszko, W. & EAACI Task Force Clinical Practice (2019), Preschool wheezing diagnosis and management-Survey of physicians' and caregivers' perspective.
- McSorley, H.J.; Chaye, M.A.M. & Smits, H.H. (2019), Worms: Pernicious parasites or allies against allergies?, Parasite Immunology 41(6).
- Mouser, E.E.I.M.; Pollakis, G.; Smits, H.H.; Thomas, J.; Yazdanbakhsh, M.; Jong, E.C. de & Paxton, W.A. (2019), Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4(+) T-lymphocyte responses and HIV-1 infection in vitro, PLoS Pathogens 15(9).
- Obieglo, K.; Costain, A.; Webb, L.M.; Ozir-Fazalalikhan, A.; Brown, S.L.; MacDonald, A.S. & Smits, H.H. (2019), Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs, European Journal of Immunology 49(8): 1226-1234.
- Janse, J.J.; Langenberg, M.C.C.; Kos-Van Oosterhoud, J.; Ozir-Fazalalikhan, A.; Brienen, E.A.T.; Winkel, B.M.F.; Erkens, M.A.A.; Beek, M.T. van der; Lieshout, L. van; Smits, H.H.; Webster, B.L.; Zandvliet, M.L.; Verbeek, R.; Westra, I.M.; Meij, P.; Visser, L.G.; Diepen, A. van; Hokke, C.H.; Yazdanbakhsh, M. & Roestenberg, M. (2018), Establishing the Production of Male Schistosoma mansoni Cercariae for a Controlled Human Infection Model, Journal of Infectious Diseases 218(7): 1142-1146.
- Kuipers, M.E.; Hokke, C.H.; Smits, H.H. & Hoene, E.N.M.N.'. (2018), Pathogen-Derived Extracellular Vesicle-Associated Molecules That Affect the Host Immune System: An Overview, Frontiers in Microbiology 9.
- Costain, A.H.; MacDonald, A.S. & Smits, H.H. (2018), Schistosome Egg Migration: Mechanisms, Pathogenesis and Host Immune Responses, Frontiers in Immunology 9.
- Wijck, Y. van; Kleijn, S. de; John-Schuster, G.; Mertens, T.C.J.; Hiemstra, P.S.; Muller, A.; Smits, H.H. & Taube, C. (2018), Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease, Journal of Immunology 200(5): 1570-1579.
- Winkel, B.M.; Dalenberg, M.R.; Feijt, C.; Korne, C.M. de; Oosterhoud, J.K.V.; Langenberg, M.C.; Pelgrom, L.R.; Ganesh, M.S.; Smits, H.H.; Leeuwen, F.W. van; Yazdanbakhsh, M.; Jong, E.C. de; Everts, B.; Hokke, C.H. & Roestenberg, M. (2018), REGULATORY RESPONSES TO SCHISOSOMA MANSONI ARE INITIATED IN THE HUMAN SKIN: SKIN PENETRATING CERCARIAE INDUCE REGULATORY DERMAL APCS, American Journal of Tropical Medicine and Hygiene 99(4): 229-229.
- Vlugt, L.E.P.M. van der; Eger, K.; Muller, C.; Ninaber, D.K.; Zarcone, M.C.; Amatngalim, G.D.; Bracher, F.; Mutius, E. von; Smits, H.H. & Hiemstra, P.S. (2018), Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses, Journal of Allergy and Clinical Immunology 141(5): 1949-+.
- Obieglo, K.; Schuijs, M.J.; Ozir-Fazalalikhan, A.; Otto, F.; Wijck, Y. van; Boon, L.; Lambrecht, B.N.; Taube, C. & Smits, H.H. (2018), Isolated Schistosoma mansoni eggs prevent allergic airway inflammation, Parasite Immunology 40(10).
- Winkel, B.M.F.; Dalenberg, M.R.; Korne, C.M. de; Feijt, C.; Langenberg, M.C.C.; Pelgrom, L.; Ganesh, M.S.; Yazdanbakhsh, M.; Smits, H.H.; Jong, E.C. de; Everts, B.; Leeuwen, F.W.B. van; Hokke, C.H. & Roestenberg, M. (2018), Early Induction of Human Regulatory Dermal Antigen Presenting Cells by Skin-Penetrating Schistosoma Mansoni Cercariae, Frontiers in Immunology 9.
- Maizels, R.M.; Smits, H.H. & McSorley, H.J. (2018), Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules, Immunity 49(5): 801-818.
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Langenberg, M.; Hoogerwerf, M.A.; Janse, J.; Kos-van Oosterhoud, J.; Feijt, C.; Dood, C. de; Ganesh, M.; Ozir-Fazalakhan, A.; Kruize, Y.; Winkel, B.; Hardeman, G.; Verbeek-Menken, P.; Beek, M. van der; Brienen, E.; Diepen, A. van; Corstjens, P.; Visser, L.; Lieshout, L. van; Smits, H.; Meij, P.; Dam, G. van; Hokke, R.; Yazdanbakhsh, M. & Roestenberg, M. (2018), CONTROLLED HUMAN INFECTION WITH SINGLE-SEX
SCHISTOSOMA MANSONI CERCARIAE, American Journal of Tropical Medicine and Hygiene 99(4): 461-461. - Vlugt, L.E.P.M. van der; Obieglo, K.; Ozir-Fazalalikhan, A.; Sparwasser, T.; Haeberlein, S. & Smits, H.H. (2017), Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function, International Journal for Parasitology 47(9): 545-554.
- John-Schuster, G.; Kleijn, S. de; Wijck, Y. van; Kremer, V.; Smits, H.H.; Pieper, M.P.; Hiemstra, P.S. & Taube, C. (2017), The effect of tiotropium in combination with olodaterol on house dust mite-induced allergic airway disease, Pulmonary Pharmacology and Therapeutics 45: 210-217.
- Haeberlein, S.; Chevalley-Maurel, S.; Ozir-Fazalalikhan, A.; Koppejan, H.; Winkel, B.M.F.; Ramesar, J.; Khan, S.M.; Sauerwein, R.W.; Roestenberg, M.; Janse, C.J.; Smits, H.H. & Franke-Fayard, B. (2017), Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load, Scientific Reports 7.
- Haeberlein, S.; Obieglo, K.; Ozir-Fazalalikhan, A.; Chaye, M.A.M.; Veninga, H.; Vlugt, L.E.P.M. van der; Voskamp, A.; Boon, L.; Haan, J.M.M. den; Westerhof, L.B.; Wilbers, R.H.P.; Schots, A.; Schramm, G.; Hokke, C.H. & Smits, H.H. (2017), Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells, PLoS Pathogens 13(7).
- Jong, S.E. de; Asscher, V.E.R.; Wammes, L.J.; Wiria, A.E.; Hamid, F.; Sartono, E.; Supali, T.; Smits, H.H.; Luty, A.J.F. & Yazdanbakhsh, M. (2017), Longitudinal study of changes in gamma delta T cells and CD4+ T cells upon asymptomatic malaria infection in Indonesian children, Scientific Reports 7.
- Wilbers, R.H.P.; Westerhof, L.B.; Noort, K. van; Obieglo, K.; Driessen, N.N.; Everts, B.; Gringhuis, S.I.; Schramm, G.; Goverse, A.; Smant, G.; Bakker, J.; Smits, H.H.; Yazdanbakhsh, M.; Schots, A. & Hokke, C.H. (2017), Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants, Scientific Reports 7.
- Langenberg, M.; Janse, J.; Hoogerwerf, M.A.; Kos-van Oosterhoud, J.; Ozir-Fazalakhan, A.; Hokke, R.; Diepen, A. van; Brienen, E.; Lieshout, L. van; Smits, H.; Beek, M. van der; Meij, P.; Verbeek, R.; Visser, L.; Yazdanbakhsh, M. & Roestenberg, M. (2017), CONTROLLED HUMAN INFECTION WITH SINGLE-SEX SCHISTOSOMA MANSONI CERCARIAE, American Journal of Tropical Medicine and Hygiene 97(5): 33-33.
- Smits, H.H.; Hiemstra, P.S.; Costa, C.P. da; Ege, M.; Edwards, M.; Garn, H.; Howarth, P.H.; Jartti, T.; Jong, E.C. de; Maizels, R.M.; Marsland, B.J.; McSorley, H.J.; Muller, A.; Pfefferle, P.I.; Savelkoul, H.; Schwarze, J.; Unger, W.W.J.; Mutius, E. von; Yazdanbakhsh, M. & Taube, C. (2016), Microbes and asthma: Opportunities for intervention, Journal of Allergy and Clinical Immunology 137(3): 690-697.
- Smits, H.H.; Vlugt, L.E.P.M. van der; Mutius, E. von & Hiemstra, P.S. (2016), Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier, Current Opinion in Immunology 42: 41-47.
- Lucassen, E.A.; Coomans, C.P.; Putten, M. van; Kreij, S.R. de; Genugten, J.H.L.T. van; Sutorius, R.P.M.; Rooij, K.E. de; Velde, M. van der; Verhoeve, S.L.; Smit, J.W.A.; Lowik, C.W.G.M.; Smits, H.H.; Guigas, B.; Aartsma-Rus, A.M. & Meijer, J.H. (2016), Environmental 24-hr Cycles Are Essential for Health, Current Biology 26(14): 1843-1853.
- Joosten, S.A.; Meijgaarden, K.E. van; Nonno, F. del; Baiocchini, A.; Petrone, L.; Vanini, V.; Smits, H.H.; Palmieri, F.; Goletti, D. & Ottenhoff, T.H.M. (2016), Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment, PLoS Pathogens 12(6).
- Schmiedel, Y.; Mombo-Ngoma, G.; Labuda, L.A.; Janse, J.J.; Gier, B. de; Adegnika, A.A.; Issifou, S.; Kremsner, P.G.; Smits, H.H. & Yazdanbakhsh, M. (2015), CD4(+) CD25(hi)FOXP3(+) Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel, PLoS Neglected Tropical Diseases 9(8).
- Ateba-Ngoa, U.; Adegnika, A.A.; Zinsou, J.F.; Kassa, R.F.K.; Smits, H.; Massinga-Loembe, M.; Mordmuller, B.; Kremsner, P.G. & Yazdanbakhsh, M. (2015), Cytokine and chemokine profile of the innate and adaptive immune response of schistosoma haematobium and plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambarene, Gabon, Malaria Journal 14.
- Bossche, J. van den; Laoui, D.; Naessens, T.; Smits, H.H.; Hokke, C.H.; Stijlemans, B.; Grooten, J.; Baetselier, P. de & Ginderachter, J.A. van (2015), E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo, Scientific Reports 5.
- Kurakula, K.; Vos, M.; Eijk, M. van; Smits, H.H. & Vries, C.J.M. de (2015), LIM-only protein FHL2 regulates experimental pulmonary Schistosoma mansoni egg granuloma formation, European Journal of Immunology 45(11): 3098-3106.
- Vlugt, L.E.P.M. van der; Zinsou, J.F.; Ozir-Fazalalikhan, A.; Kremsner, P.G.; Yazdanbakhsh, M.; Adegnika, A.A. & Smits, H.H. (2014), Interleukin 10 (IL-10)-Producing CD1d(hi) Regulatory B Cells From Schistosoma Haematobium-Infected Individuals Induce IL-10-Positive T Cells and Suppress Effector T-Cell Cytokines, Journal of Infectious Diseases 210(8): 1207-1216.
- Obieglo, K.; Wijck, Y. van; Kleijn, S. de; Smits, H.H. & Taube, C. (2014), Microorganism-induced suppression of allergic airway disease: novel therapies on the horizon?, Expert Review of Respiratory Medicine 8(6): 717-730.
- Smits, H.H. & Akdis, C.A. (2014), In utero priming by worms protects against respiratory allergies, Journal of Allergy and Clinical Immunology 134(6): 1280-1281.
- Sattler, S.; Ling, G.S.; Xu, D.M.; Hussaarts, L.; Romaine, A.; Zhao, H.Z.; Fossati-Jimack, L.; Malik, T.; Cook, H.T.; Botto, M.; Lau, Y.L.; Smits, H.H.; Liew, F.Y. & Huang, F.P. (2014), IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut, Journal of Autoimmunity 50: 107-122.
- Vlugt, L.E.P.M. van der; Mlejnek, E.; Ozir-Fazalalikhan, A.; Bonas, M.J.; Dijksman, T.R.; Labuda, L.A.; Schot, R.; Guigas, B.; Moller, G.M.; Hiemstra, P.S.; Yazdanbakhsh, M. & Smits, H.H. (2014), CD24 (hi) CD27 (+) B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide, Clinical and Experimental Allergy 44(4): 517-528.
- Gloudemans, A.K.; Plantinga, M.; Guilliams, M.; Willart, M.A.; Ozir-Fazalalikhan, A.; Ham, A. van der; Boon, L.; Harris, N.L.; Hammad, H.; Hoogsteden, H.C.; Yazdanbakhsh, M.; Hendriks, R.W.; Lambrecht, B.N. & Smits, H.H. (2013), The Mucosal Adjuvant Cholera Toxin B Instructs Non-Mucosal Dendritic Cells to Promote IgA Production Via Retinoic Acid and TGF-beta, PLoS ONE 8(3).
- Sattler, S.; Smits, H.H.; Xu, D.M. & Huang, F.P. (2013), The Evolutionary Role of the IL-33/ST2 System in Host Immune Defence, Archivum Immunologiae et Therapiae Experimentalis 61(2): 107-117.
- Gloudemans, A.K.; Lambrecht, B.N. & Smits, H.H. (2013), Potential of Immunoglobulin A to Prevent Allergic Asthma, Clinical and Developmental Immunology.
- Wammes, L.J.; Wiria, A.E.; Toenhake, C.G.; Hamid, F.; Liu, K.Y.; Suryani, H.; Kaisar, M.M.M.; Verweij, J.J.; Sartono, E.; Supali, T.; Smits, H.H.; Luty, A.J. & Yazdanbakhsh, M. (2013), Asymptomatic Plasmodial Infection Is Associated With Increased Tumor Necrosis Factor Receptor II-Expressing Regulatory T Cells and Suppressed Type 2 Immune Responses, Journal of Infectious Diseases 207(10): 1590-1599.
- Hussaarts, L.; Smits, H.H.; Schramm, G.; Ham, A.J. van der; Zon, G.C. van der; Haas, H.; Guigas, B. & Yazdanbakhsh, M. (2013), Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells, Immunology and Cell Biology 91(7): 486-489.
- Labuda, L.A.; Ateba-Ngoa, U.; Feugap, E.N.; Heeringa, J.J.; Vlugt, L.E.P.M. van der; Pires, R.B.A.; Mewono, L.; Kremsner, P.G.; Zelm, M.C. van; Adegnika, A.A.; Yazdanbakhsh, M. & Smits, H.H. (2013), Alterations in Peripheral Blood B Cell Subsets and Dynamics of B Cell Responses during Human Schistosomiasis, PLoS Neglected Tropical Diseases 7(3).
- Mbow, M.; Larkin, B.M.; Meurs, L.; Wammes, L.J.; Jong, S.E. de; Labuda, L.A.; Camara, M.; Smits, H.H.; Polman, K.; Dieye, T.N.; Mboup, S.; Stadecker, M.J. & Yazdanbakhsh, M. (2013), T-Helper 17 Cells Are Associated With Pathology in Human Schistosomiasis.
- Vlugt, L.E.P.M. van der; Mlejnek, E.; Ozir-Fazalalikhan, A.; Dijksman, T.R.; Labuda, L.A.; Schot, R.; Hiemstra, P.S.; Moller, G.M.; Yazdanbakhsh, M. & Smits, H.H. (2012), Reduced B cell IL-10 in response to LPS in Allergic Asthma patients: an impaired Breg function?, Immunology 137: 459-459.
- Larkin, B.; Mbow, M.; Meurs, L.; Wammes, L.; Jong, S. de; Labuda, L.; Smits, H.; Dieye, T.; Polman, K.; Mboup, S.; Stadecker, M. & Yazdanbakhsh, M. (2012), Th17 cells are associated with pathology in human schistosomiasis, Journal of Immunology 188: -.
- Hellingman, A.A.; Vlugt, L.E.P.M. van der; Lijkwan, M.A.; Bastiaansen, A.J.N.M.; Sparwasser, T.; Smits, H.H.; Hamming, J.F. & Quax, P.H.A. (2012), A limited role for regulatory T cells in post-ischemic neovascularization, Journal of Cellular and Molecular Medicine 16(2): 328-336.
- Meevissen, M.H.J.; Driessen, N.N.; Smits, H.H.; Versteegh, R.; Vliet, S.J. van; Kooyk, Y. van; Schramm, G.; Deelder, A.M.; Haas, H.; Yazdanbakhsh, M. & Hokke, C.H. (2012), Specific glycan elements determine differential binding of individual egg glycoproteins of the human parasite Schistosoma mansoni by host C-type lectin receptors, International Journal for Parasitology 42(3): 269-277.
- Smits, H.H. (2012), B cells in allergic diseases: Bad or Better?, Autoimmunity 45(5): 415-426.
- Everts, B.; Hussaarts, L.; Driessen, N.N.; Meevissen, M.H.J.; Schramm, G.; Ham, A.J. van der; Hoeven, B. van der; Scholzen, T.; Burgdorf, S.; Mohrs, M.; Pearce, E.J.; Hokke, C.H.; Haas, H.; Smits, H.H. & Yazdanbakhsh, M. (2012), Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor.
- Vlugt, L.E.P.M. van der; Ozir-Fazalalikhan, A.; Verbeek, J.S.; Boon, L.; Yazdanbakhsh, M. & Smits, H.H. (2012), Schistosomes induce pulmonary regulatory B cells that are involved in protection against allergic airway inflammation, Immunology 137: 83-84.
- Wammes, L.J.; Hamid, F.; Wiria, A.E.; Wibowo, H.; Sartono, E.; Maizels, R.M.; Smits, H.H.; Supali, T. & Yazdanbakhsh, M. (2012), Regulatory T Cells in Human Lymphatic Filariasis: Stronger Functional Activity in Microfilaremics, PLoS Neglected Tropical Diseases 6(5): -.
- Vlugt, L.E.P.M. van der; Labuda, L.A.; Ozir-Fazalalikhan, A.; Lievers, E.; Gloudemans, A.K.; Liu, K.Y.; Barr, T.A.; Sparwasser, T.; Boon, L.; Ngoa, U.A.; Feugap, E.N.; Adegnika, A.A.; Kremsner, P.G.; Gray, D.; Yazdanbakhsh, M. & Smits, H.H. (2012), Schistosomes Induce Regulatory Features in Human and Mouse CD1d(hi) B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells, PLoS ONE 7(2): -.
- Hussaarts, L.; Vlugt, L.E.P.M. van der; Yazdanbakhsh, M. & Smits, H.H. (2011), Regulatory B-cell induction by helminths: Implications for allergic disease.
- Wammes, L.J.; Hamid, F.; Wiria, A.E.; Gier, B. de; Sartono, E.; Maizels, R.M.; Luty, A.J.F.; Fillie, Y.; Brice, G.T.; Supali, T.; Smits, H.H. & Yazdanbakhsh, M. (2010), Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum, European Journal of Immunology 40(2): 437-442.
- Everts, B.; Smits, H.H.; Hokke, C.H. & Yazdanbakhsh, M. (2010), Helminths and dendritic cells: Sensing and regulating via pattern recognition receptors, Th2 and Treg responses, European Journal of Immunology 40(6): 1525-1537.
- Everts, B.; Adegnika, A.A.; Kruize, Y.C.M.; Smits, H.H.; Kremsner, P.G. & Yazdanbakhsh, M. (2010), Functional Impairment of Human Myeloid Dendritic Cells during Schistosoma haematobium Infection, PLoS Neglected Tropical Diseases 4(4).
- Smits, H.H.; Everts, B.; Hartgers, F.C. & Yazdanbakhsh, M. (2010), Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes, Current Allergy and Asthma Reports 10(1): 3-12.
- Smits HH, Gloudemans AK, van Nimwegen M, Willart MA, Soullie T, Muskens F, de Jong EC, Boon L, Pilette C & Johansen FE (2009), Cholera toxin B suppresses allergic inflammation through induction of secretory IgA, Mucosal Immunology 2(4): 331-339.
- Everts B, Perona-Wright G, Smits HH, Hokke CH, van der Ham AJ, Fitzsimmons CM, Doenhoff MJ, van der Bosch J, Mohrs K & Haas H (2009), Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses, Journal of Experimental Medicine 206(8): 1673-1680.
- Yazdanbakhsh M, van Riet E, Obeng B, Boakye D, Smits H & Hartgers F (2005), Helminth infections, allergies and responses to third party antigens, Immunology 116: 20-20.
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