Erik Olofsen
- Name
- Dr.ir. E. Olofsen
- Telephone
- +31 71 526 3344
- e.olofsen@lumc.nl
- Faculteit Geneeskunde
- LUMC - Medische Faculteit Leiden
- Divisie 1
- Anesthesiologie
- Simons, P.; Schrier, R. van der; Lemmen, M. van; Jansen, S.; Kuijpers, K.W.K.; Velzen, M. van; Sarton, E.; Nicklas, T.; Michalsky, C.; Demitrack, M.A.; Fossler, M.; Olofsen, E.; Niesters, M. & Dahan, A. (2023), Respiratory Effects of Biased Ligand Oliceridine in Older Volunteers: A Pharmacokinetic-Pharmacodynamic Comparison with Morphine, Anesthesiology 138(3): 249-263.
- Schrier, R. van der; Velzen, M. van; Roozekrans, M.; Sarton, E.; Olofsen, E.; Niesters, M.; Smulders, C. & Dahan, A. (2022), Carbon dioxide tolerability and toxicity in rat and man, Frontiers in Toxicology 4.
- Simons, P.; Olofsen, E.; Velzen, M. van; Lemmen, M. van; Dasselaar, T. van; Mohr, P.; Hammes, F.; Schrier, R. van der; Niesters, M. & Dahan, A. (2022), S-Ketamine oral thin film-Part 2: Population pharmacodynamics of S-ketamine, S-norketamine and S-hydroxynorketamine, Frontiers in Pain Research 3.
- Simons, P.; Olofsen, E.; Velzen, M. van; Lemmen, M. van; Mooren, R.; Dasselaar, T. van; Mohr, P.; Hammes, F.; Schrier, R. van der; Niesters, M. & Dahan, A. (2022), S-Ketamine Oral Thin Film-Part 1: Population Pharmacokinetics of S-Ketamine, S-Norketamine and S-Hydroxynorketamine, Frontiers in Pain Research 3.
- Kamp, J.; Olofsen, E.; Henthorn, T.K.; Velzen, M. van; Niesters, M.; Dahan, A. & Ketamine Pharmacokinetic Study Gr (2020), Ketamine pharmacokinetics a systematic review of the literature, meta-analysis, and population analysis, Anesthesiology 133(6): 1192-1213.
- Kamp, J.; Jonkman, K.; Velzen, M. van; Aarts, L.; Niesters, M.; Dahan, A. & Olofsen, E. (2020), Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis, British Journal of Anaesthesia 125(5): 750-761.
- G (2020), Deep neuromuscular block does not improve surgical conditions in patients receiving sevoflurane anesthesia for laparoscopic renal surgery, British Journal of Anaesthesia.
- Olofsen, E.; Boom, M.; Sarton, E.; Velzen, M. van; Baily, P.; Smith, K.J.; Oksche, A.; Dahan, A. & Niesters, M. (2019), Analgesic and Respiratory Depressant Effects of R-dihydroetorphine A Pharmacokinetic-Pharmacodynamic Analysis in Healthy Male Volunteers, Anesthesiology 131(6): 1327-1339.
- Kamp, J.; Velzen, M. van; Olofsen, E.; Boon, M.; Dahan, A. & Niesters, M. (2019), Pharmacokinetic and pharmacodynamic considerations for NMDA-receptor antagonist ketamine in the treatment of chronic neuropathic pain: an update of the most recent literature, Expert Opinion on Drug Metabolism and Toxicology.
- Algera, M.H.; Kamp, J.; Schrier, R. van der; Velzen, M. van; Niesters, M.; Aarts, L.; Dahan, A. & Olofsen, E. (2019), Opioid-induced respiratory depression in humans: a review of pharmacokinetic-pharmacodynamic modelling of reversal, British Journal of Anaesthesia 122(6): E168-E179.
- Meijer, F.S.; Martini, C.H.; Broens, S.; Boon, M.; Niesters, M.; Aarts, L.; Olofsen, E.; Velzen, M. van & Dahan, A. (2019), Nociception-guided versus Standard Care during Remifentanil-Propofol Anesthesia A Randomized Controlled Trial, Anesthesiology 130(5): 745-755.
- Donk, T. van de; Niesters, M.; Kowal, M.A.; Olofsen, E.; Dahan, A. & Velzen, M. van (2019), An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia, PAIN 160(4): 860-869.
- Donk, T. van de; Niesters, M.; Kowal, M.A.; Olofsen, E.; Dahan, A. & Velzen, M. van (2019), An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia, PAIN 00(4).
- Meijer, F.S.; Martini, C.H.; Broens, S.; Boon, M.; Niesters, M.; Aarts, L.; Olofsen, E.; Velzen, M. van & Dahan, A. (2019), Nociception-guided versus Standard Care during Remifentanil-Propofol Anesthesia: A Randomized Controlled Trial., Anesthesiology 130(5).
- Henthorn, T.K.; Avram, M.J.; Dahan, A.; Gustafsson, L.L.; Persson, J.; Krejcie, T.C. & Olofsen, E. (2018), Combined Recirculatory-compartmental Population Pharmacokinetic Modeling of Arterial and Venous Plasma S(+) and R(-) Ketamine Concentrations, Anesthesiology 129(2): 260-270.
- Roozekrans, M.; Schrier, R. van der; Aarts, L.; Sarton, E.; Velzen, M. van; Niesters, M.; Dahan, A. & Olofsen, E. (2018), Benefit versus Severe Side Effects of Opioid Analgesia Novel Utility Functions of Probability of Analgesia and Respiratory Depression, Anesthesiology 128(5): 932-942.
- Jonkman, K.; Schrier, R. van der; Velzen, M. van; Aarts, L.; Olofsen, E.; Sarton, E.; Niesters, M. & Dahan, A. (2018), Differential role of nitric oxide in the psychedelic symptoms induced by racemic ketamine and esketamine in human volunteers, British Journal of Anaesthesia 120(5): 1009-1018.
- Jonkman, K.; Rijnsoever, E. van; Olofsen, E.; Aarts, L.; Sarton, E.; Velzen, M. van; Niesters, M. & Dahan, A. (2018), Esketamine counters opioid-induced respiratory depression, British Journal of Anaesthesia 120(5): 1117-1127.
- Olesen, A.E.; Broens, S.; Olesen, S.S.; Niesters, M.; Velzen, M. van; Drewes, A.M.; Dahan, A. & Olofsen, E. (2018), A pragmatic utility function to describe the risk-benefit composite of opioid and non-opioid analgesic medication., Journal of Pharmacology and Experimental Therapeutics.
- Eleveld, D.J.; Proost, J.H.; Vereecke, H.; Absalom, A.R.; Olofsen, E.; Vuyk, J. & Struys, M.M.R.F. (2017), An Allometric Model of Remifentanil Pharmacokinetics and Pharmacodynamics, Anesthesiology 126(6): 1005-1018.
- Olofsen E. (21 June 2017), Pharmacokinetic and pharmacodynamic analysis in anesthesia : a modeling odyssey (Dissertatie, Medicine, Leiden University). Supervisor(s) and Co-supervisor(s): Dahan A., Niesters M.
- Moes, D.J.A.R.; Bent, S.A.S. van der; Swen, J.J.; Straaten, T. van der; Inderson, A.; Olofsen, E.; Verspaget, H.W.; Guchelaar, H.J.; Hartigh, J. den & Hoek, B. van (2016), Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients, European Journal of Clinical Pharmacology 72(2): 163-174.
- Olesen, A.E.; Olofsen, E.; Andresen, T.; Graversen, C.; Drewes, A.M. & Dahan, A. (2015), Stochastic Pharmacokinetic-Pharmacodynamic Analysis of the Effect of Transdermal Buprenorphine on Electroencephalogram and Analgesia, Anesthesia and Analgesia 121(5): 1165-1175.
- Khalili-Mahani, N.; Martini, C.H.; Olofsen, E.; Dahan, A. & Niesters, M. (2015), Effect of subanaesthetic ketamine on plasma and saliva cortisol secretion, British Journal of Anaesthesia 115(1): 68-75.
- Roozekrans, M.; Olofsen, E.; Schrier, R. van der; Gerven, J. van; Peng, S.; McLeod, J. & Dahan, A. (2015), Reversal of opioid-induced respiratory depression by BK-channel blocker GAL021: A pharmacokinetic-pharmacodynamic modeling study in healthy volunteers, Clinical Pharmacology and Therapeutics 97(6): 641-649.
- Dahan, A.; Olofsen, E. & Niesters, M. (2015), Pharmacotherapy for pain: efficacy and safety issues examined by subgroup analyses, PAIN 156(4): S119-S126.
- Martini, C.H.; Proto, P.; Olofsen, E.; Velzen, M. van; Aarts, L.; Dahan, A. & Niesters, M. (2015), A randomized controlled trial and novel mathematical analysis of the analgesic effect of oxycodone versus paracetamol orodispersible tablets, European Journal of Pain 19(3): 295-304.
- Olofsen, E.; Dahan, A.; Borsboom, G. & Drummond, G. (2015), Improvements in the application and reporting of advanced Bland-Altman methods of comparison.
- Olofsen, E. & Dahan, A. (2015), Big Brain, Small World?, Anesthesiology 122(1): 8-11.
- Sitsen, E.; Olofsen, E.; Lesman, A.; Dahan, A. & Vuyk, J. (2015), Epidural Blockade Affects the Pharmacokinetics of Propofol in Surgical Patients, Anesthesia and Analgesia 122(5).
- Martini, C.H.; Yassen, A.; Krebs-Brown, A.; Passier, P.; Stoker, M.; Olofsen, E. & Dahan, A. (2013), A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia, European Journal of Pain 17(10): 1491-1501.
- Boom, M.; Olofsen, E.; Neukirchen, M.; Fussen, R.; Hay, J.; Groeneveld, G.J.; Aarts, L.; Sarton, E. & Dahan, A. (2013), Fentanyl Utility Function: A Risk-Benefit Composite of Pain Relief and Breathing Responses, Anesthesiology 119(3): 663-674.
- Olofsen, E. & Dahan, A. (2011), Opioid Modeling of Central Respiratory Drive Must Take Upper Airway Obstruction into Account Reply, Anesthesiology 114(1): 220-221.
- Olofsen, E.; Mooren, R.; Dorp, E. van; Aarts, L.; Smith, T.; Hartigh, J. den; Dahan, A. & Sarton, E. (2010), Arterial and Venous Pharmacokinetics of Morphine-6-Glucuronide and Impact of Sample Site on Pharmacodynamic Parameter Estimates, Anesthesia and Analgesia 111(3): 626-632.
- Olofsen, E.; Boom, M.; Nieuwenhuijs, D.; Sarton, E.; Teppema, L.; Aarts, L. & Dahan, A. (2010), Modeling the Non-Steady State Respiratory Effects of Remifentanil in Awake and Propofol-sedated Healthy Volunteers, Anesthesiology 112(6): 1382-1395.
- Olofsen, E.; Dorp, E. van; Teppema, L.; Aarts, L.; Smith, T.W.; Dahan, A. & Sarton, E. (2010), Naloxone Reversal of Morphine- and Morphine-6-Glucuronide-induced Respiratory Depression in Healthy Volunteers A Mechanism-based Pharmacokinetic-Pharmacodynamic Modeling Study, Anesthesiology 112(6): 1417-1427.
- Lichtenbelt, B.J.; Olofsen, E.; Dahan, A.; Kleef, J.W. van; Struys, M.M.R.F. & Vuyk, J. (2010), Propofol Reduces the Distribution and Clearance of Midazolam, Anesthesia and Analgesia 110(6): 1597-1606.
- Sigtermans, M.; Noppers, I.; Sarton, E.; Bauer, M.; Mooren, R.; Olofsen, E. & Dahan, A. (2010), An observational study on the effect of S(+)-ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients, European Journal of Pain 14(3): 302-307.
- Sigtermans M, Dahan A, Mooren R, Bauer M, Kest B, Sarton E & Olofsen E (2009), S(+)-ketamine Effect on Experimental Pain and Cardiac Output A Population Pharmacokinetic-Pharmacodynamic Modeling Study in Healthy Volunteers, Anesthesiology 111(4): 892-903.
- Vuyk J, Lichtenbelt BJ, Olofsen E, van Kleef JW & Dahan A (2009), Mixed-Effects Modeling of the Influence of Midazolam on Propofol Pharmacokinetics, Anesthesia and Analgesia 108(5): 1522-1530.
- Hogers B, van der Weerd L, Olofsen H, van der Graaf LM, DeRuiter MC, Groot ACGD & Poelmann RE (2009), Non-invasive tracking of avian development in vivo by MRI, NMR in Biomedicine 22(4): 365-373.
- Olofsen E, Burm AGL, Simon MJG, Veering BT, van Kleef JW & Dahan A (2008), Population pharmacokinetic-pharmacoadynamic modeling of epidural anesthesia, Anesthesiology 109(4).
- Yassen A, Olofsen E, Kan J, Dahan A & Danhof M (2008), Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats, Pharmaceutical Research 25(1).
- Yassen A, Kan JM, Olofsen E, Suidgeest E, Dahan A & Danhof M (2007), Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats, Journal of Pharmacology and Experimental Therapeutics 321(2).
- Yassen A, Olofsen E, van Dorp E, Sarton E, Teppema L, Danhof M & Dahan A (2007), Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone - A study in healthy volunteers, Clinical Pharmacokinetics 46(11).
- Yassen A, Kan JM, Olofsen E, Suidgeest E, Dahan A & Danhof M (2006), Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats, Journal of Pharmacology and Experimental Therapeutics 319(2).
- van Dorp E, Yassen A, Sarton E, Romberg R, Olofsen E, Teppema L, Danhof M & Dahan A (2006), Naloxone reversal of buprenorphine-induced respiratory depression, Anesthesiology 105(1).
- Yassen A, Olofsen E, Romberg R, Sarton E, Danhof M & Dahan A (2006), Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers, Anesthesiology 104(6).
- Dahan A, Yassen A, Romberg R, Sarton E, Teppema L, Olofsen E & Danhof M (2006), Buprenorphine induces ceiling in respiratory depression but not in analgesia, British Journal of Anaesthesia 96(5).
- Olofsen E, Romberg R, Bijl H, Mooren R, Engbers F, Kest B & Dahan A (2005), Alfentanil and placebo analgesia - No sex differences detected in models of experimental pain, Anesthesiology 103(1).
- Dahan A, Yassen A, Bijl H, Romberg R, Sarton E, Teppema L, Olofsen E & Danhof M (2005), Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats, British Journal of Anaesthesia 94(6).
- Yassen A, Olofsen E, Dahan A & Danhof M (2005), Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: Role of receptor equilibration kinetics, Journal of Pharmacology and Experimental Therapeutics 313(3).
- Romberg RR, Olofsen E, Bijl H, Taschner PEM, Teppema LJ, Sarton EY, van Kleef JW & Dahan A (2005), Polymorphism of mu-opioid receptor gene (OPRM1 : c.118A > G) does not protect against opioid-induced respiratory depression despite reduced analgesic response, Anesthesiology 102(3).
- Romberg R, Olofsen E, Sarton E, Teppema L & Dahan A (2004), Increased margin of safety of morphine-6-glucuronide relative to morphine, Anesthesiology 100(6).
- Mertens MJ, Olofsen E, Burm AGL, Bovill JG & Vuyk J (2004), Mixed-effects modeling of the influence of alfentanil on propofol pharmacokinetics, Anesthesiology 100(4).
- Olofsen E, Dinges DF & Van Dongen HPA (2004), Nonlinear mixed-effects modeling: Individualization and prediction, Aviation, Space, and Environmental Medicine 75(3).
- Romberg R, Olofsen E, Sarton E, den Hartigh J, Taschner PEM & Dahan A (2004), Pharmacokinetic-pharmacodynamic modeling of morphine-6-glucuronide-induced analgesia in healthy volunteers - Absence of sex differences, Anesthesiology 100(1).
- Van Dongen HPA, Olofsen E, Dinges DF & Maislin G (2004), Mixed-model regression analysis and dealing with interindividual differences, Methods in Enzymology 384.
- Romberg R, Olofsen E, Sarton E, Teppema L & Dahan A (2003), Pharmacodynamic effect of morphine-6-glucuronide versus morphine on hypoxic and hypercapnic breathing in healthy volunteers, Anesthesiology 99(4).
- Mertens MJ, Olofsen E, Engbers FHM, Burm AGL, Bovill JG & Vuyk J (2003), Propofol reduces perioperative remifentanil requirements in a synergistic manner - Response surface modeling of perioperative remifentanil-propofol interactions, Anesthesiology 99(2).
- Nieuwenhuijs DJF, Olofsen E, Romberg RR, Sarton E, Ward D, Engbers F, Vuyk J, Mooren R, Teppema LJ & Dahan A (2003), Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index, Anesthesiology 98(2).
- Higuchi H, Adachi Y, Dahan A, Olofsen E, Arimura S, Mori T & Satoh T (2002), The interaction between propofol and clonidine for loss of consciousness, Anesthesia and Analgesia 94(4).
- Olofsen E, Sleigh JW & Dahan A (2002), The influence of remifentanil on the dynamic relationship between sevoflurane and surrogate anesthetic effect measures derived from the EEG, Anesthesiology 96(3).
- Mertens MJ, Vuyk J, Olofsen E, Bovill JG & Burm AGL (2001), Propofol alters the pharmacokinetics of alfentanil in healthy male volunteers, Anesthesiology 94(6).
- Dahan A, Nieuwenhuijs D, Olofsen E, Sarton E, Romberg R & Teppema L (2001), Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index, Anesthesiology 94(6).
- Kuipers JA, Boer F, de Roode A, Olofsen E, Bovill JG & Burm AGL (2001), Modeling population pharmacokinetics of lidocaine - Should cardiac output be included as a patient factor?, Anesthesiology 94(4).
- Kuipers JA, Boer F, Olofsen E, Bovill JG & Burm AGL (2001), Recirculatory pharmacokinetics and pharmacodynamics of rocuronium in patients - The influence of cardiac output, Anesthesiology 94(1).
- Olofsen E, Nieuwenhuijs DJF, Sarton EY, Teppema LJ & Dahan A (2001), Response surface modeling of drug interactions on cardiorespiratory control, Advances in Experimental Medicine and Biology 499.
- Sarton E, Olofsen E, Romberg R, den Hartigh J, Kest B, Nieuwenhuijs D, Burm A, Teppema L & Dahan A (2000), Sex differences in morphine analgesia - An experimental study in healthy volunteers, Anesthesiology 93(5).
- Olofsen E & Dahan A (2000), Dynamic response to volatile anesthetics has been examined before - Reply.
- Van Dongen HPA, Olofsen E, VanHartevelt JH & Kruyt EW (1999), Searching for biological rhythms: Peak detection in the periodogram of unequally spaced data.