Daniël Hommes
Professor
- Name
- Prof. dr. D.W. Hommes
- Telephone
- 071 5265217
- d.w.hommes@lumc.nl
- ORCID iD
- null
Professor
- Faculty of Medicine
- LUMC
Contact
- Langers, A.M.J.; Verspaget, H.W.; Hawinkels, L.J.A.C.; Kubben, F.J.G.M.; Duijn, W. van; Reijden, J.J. van der; Hardwick, J.C.H.; Hommes, D.W. & Sier, C.F.M. (2012), MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients, British Journal of Cancer 106(9): 1495-1498.
- Langers, A.M.J.; Sier, C.F.M.; Kubben, F.J.G.M.; Duijn, W. van; Reijden, J.J. van der; Hawinkels, L.J.A.C.; Koelink, R.J.; Lamers, C.B.H.W.; Hommes, D.W. & Verspaget, H.W. (2009), Prognostic impact of MMP-2 and MMP-9 gene promoter polymorphisms and their corresponding protein levels in colorectal cancer, European Journal of Gastroenterology and Hepatology 21(3): A6A7.
- Barnhoorn, M.C.; Wasser, M.N.J.M.; Roelofs, H.; Maljaars, P.W.J.; Molendijk, I.; Bonsing, B.A.; Oosten, L.E.M.; Dijkstra, G.; Woude, C.J. van der; Roelen, D.L.; Zwaginga, J.J.; Verspaget, H.W.; Fibbe, W.E.; Hommes, D.W.; Peeters, K.C.M.J. & Meulen-de Jong, A.E. van der (2020), Long-term evaluation of allogeneic bone marrow-derived mesenchymal stromal cell therapy for Crohn's disease perianal fistulas, Journal of Crohn's and Colitis 14(1): 64-70.
- Molendijk, I.; Meulen-de Jong, A.E. van der; Verspaget, H.W.; Veenendaal, R.A.; Hommes, D.W.; Bonsing, B.A. & Peeters, K.C.M.J. (2018), Standardization of mesenchymal stromal cell therapy for perianal fistulizing Crohn's disease, European Journal of Gastroenterology and Hepatology 30(10): 1148-1154.
- Erp, S.J.H. van; Have, M. van der; Fidder, H.H.; Heijde, D. van der; Wolterbeek, R.; Hommes, D.W.; Kaptein, A.A. & Meulen-de Jong, A.E. van der (2018), The effect of arthropathies on illness perceptions, coping strategies, outcomes, and their changes over time in patients with inflammatory bowel disease: a 12-month follow-up study, European Journal of Gastroenterology and Hepatology 30(4): 465-470.
- Erp, S.J.H. van; Verheul, M.K.; Levarht, E.W.N.; Reijden, J.J. van der; Heijde, D. van der; Gaalen, F.A. van; Hommes, D.W.; Norman, G.L.; Shums, Z.; Mahler, M.; Verspaget, H.W.; Trouw, L.A. & Meulen-de Jong, A.E. van der (2017), Absence of serological rheumatoid arthritis biomarkers in inflammatory bowel disease patients with arthropathies, European Journal of Gastroenterology and Hepatology 29(3): 345-348.
- Erp, S.J.H. van; Brakenhoff, L.K.M.P.; Vollmann, M.; Heijde, D. van der; Veenendaal, R.A.; Fidder, H.H.; Hommes, D.W.; Kaptein, A.A.; Meulen-de Jong, A.E. van der & Scharloo, M. (2017), Illness Perceptions and Outcomes in Patients with Inflammatory Bowel Disease: Is Coping a Mediator?, International Journal of Behavioral Medicine 24(2): 205-214.
- Erp, S. van; Ercan, E.; Breedveld, P.; Brakenhoff, L.; Ghariq, E.; Schmid, S.; Osch, M. van; Buchem, M. van; Emmer, B.; Grond, J. van der; Wolterbeek, R.; Hommes, D.; Fidder, H.; Wee, N. van der; Huizinga, T.; Heijde, D. van der; Middelkoop, H.; Ronen, I. & Meulen-de Jong, A. van der (2017), Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue, World Journal of Gastroenterology 23(6): 1018-1029.
- Erp, S.J. van; Brakenhoff, L.K.; Gaalen, F.A. van; Berg, R. van den; Fidder, H.H.; Verspaget, H.W.; Huizinga, T.W.; Veenendaal, R.A.; Wolterbeek, R.; Heijde, D. van der; Meulen-de Jong, A.E. van der & Hommes, D.W. (2016), Classifying Back Pain and Peripheral Joint Complaints in Inflammatory Bowel Disease Patients: A Prospective Longitudinal Follow-up Study, Journal of Crohn's and Colitis 10(2): 166-175.
- Molendijk, I.; Barnhoorn, M.C.; Jonge-Muller, E.S.M. de; Mieremet-Ooms, M.A.C.; Reijden, J.J. van der; Helm, D. van der; Hommes, D.W.; Meulen-de Jong, A.E. van der & Verspaget, H.W. (2016), Intraluminal Injection of Mesenchymal Stromal Cells in Spheroids Attenuates Experimental Colitis, Journal of Crohn's and Colitis 10(8): 953-964.
- Coenen, M.J.H.; Jong, D.J. de; Marrewijk, C.J. van; Derijks, L.J.J.; Vermeulen, S.H.; Wong, D.R.; Klungel, O.H.; Verbeek, A.L.M.; Hooymans, P.M.; Peters, W.H.M.; Morsche, R.H.M. te; Newman, W.G.; Scheffer, H.; Guchelaar, H.J. & Franke, B. (2015), Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease.
- Molendijk, I.; Bonsing, B.A.; Roelofs, H.; Peeters, K.C.M.J.; Wasser, M.N.J.M.; Dijkstra, G.; Woude, C.J. van der; Duijvestein, M.; Veenendaal, R.A.; Zwaginga, J.J.; Verspaget, H.W.; Fibbe, W.E.; Meulen-de Jong, A.E. van der & Hommes, D.W. (2015), Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.
- Polytarchou, C.; Hommes, D.W.; Palumbo, T.; Hatziapostolou, M.; Koutsioumpa, M.; Koukos, G.; Meulen-de Jong, A.E. van der; Oikonomopoulos, A.; Deen, W.K. van; Vorvis, C.; Serebrennikova, O.B.; Birli, E.; Choi, J.; Chang, L.; Anton, P.A.; Tsichlis, P.N.; Pothoulakis, C.; Verspaget, H.W. & Iliopoulos, D. (2015), MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.
- Oikonomopoulos, A.; Deen, W.K. van; Manansala, A.R.; Lacey, P.N.; Tomakili, T.A.; Ziman, A. & Hommes, D.W. (2015), Optimization of human mesenchymal stem cell manufacturing: the effects of animal/xeno-free media, Scientific Reports 5.
- Have, M. van der; Noomen, C.; Oldenburg, B.; Walter, D.; Houben, M.H.M.G.; Wasser, M.N.; Siersema, P.D.; Hommes, D. & Fidder, H.H. (2015), Balloon dilatation with or without intralesional and oral corticosteroids for anastomotic Crohn's disease strictures, Journal of Gastrointestinal and Liver Diseases 24(4): 537-539.
- Dewint, P.; Hansen, B.E.; Verhey, E.; Oldenburg, B.; Hommes, D.W.; Pierik, M.; Ponsioen, C.I.J.; Dullemen, H.M. van; Russel, M.; Bodegraven, A.A. van & Woude, C.J. van der (2014), Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn's disease: a randomised, double-blind, placebo controlled trial (ADAFI), Gut 63(2): 292-299.
- Deen, W.K. van; Oijen, M.G.H. van; Myers, K.D.; Centeno, A.; Howard, W.; Choi, J.M.; Roth, B.E.; McLaughlin, E.M.; Hollander, D.; Wong-Swanson, B.; Sack, J.; Ong, M.K.; Ha, C.Y.; Esrailian, E. & Hommes, D.W. (2014), A Nationwide 2010-2012 Analysis of U.S. Health Care Utilization in Inflammatory Bowel Diseases, Inflammatory Bowel Diseases 20(10): 1747-1753.
- Brakenhoff, L.K.P.M.; Stomp, W.; Gaalen, F.A. van; Hommes, D.W.; Bloem, J.L.; Heijde, D.M.F.M. van der; Fidder, H.H. & Reijnierse, M. (2014), Magnetic resonance imaging of the hand joints in patients with inflammatory bowel disease and arthralgia: a pilot study, Scandinavian Journal of Rheumatology 43(5): 416-418.
- Bodegraven, A.A. van; Bravenboer, N.; Witte, B.I.; Dijkstra, G.; Woude, C.J. van der; Stokkers, P.C.M.; Russel, M.G.; Oldenburg, B.; Pierik, M.; Roos, J.C.; Hogezand, R.A. van; Dik, V.K.; Oostlander, A.E.; Netelenbos, J.C.; Langerijt, L. van de; Hommes, D.W.; Lips, P. & Dutch Initiative Crohn Colitis ICC (2014), Treatment of bone loss in osteopenic patients with Crohn's disease: a double-blind, randomised trial of oral risedronate 35 mg once weekly or placebo, concomitant with calcium and vitamin D supplementation, Gut 63(9): 1424-1430.
- Verhaar, A.P.; Wildenberg, M.E.; Peppelenbosch, M.P.; Hommes, D.W. & Brink, G.R. van den (2014), Repurposing Miltefosine for the Treatment of Immune-Mediated Disease?, Journal of Pharmacology and Experimental Therapeutics 350(2): 189-195.
- Jharap, B.; Boer, N.K.H. de; Stokkers, P.; Hommes, D.W.; Oldenburg, B.; Dijkstra, G.; Woude, C.J. van der; Jong, D.J. de; Mulder, C.J.J.; Elburg, R.M. van; Bodegraven, A.A. van & Dutch Initiative Crohn Colitis (2014), Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease, Gut 63(3): 451-457.
- Heijmans, J.; Jeude, J.F.V. de; Koo, B.K.; Rosekrans, S.L.; Wielenga, M.C.B.; Wetering, M. van de; Ferrante, M.; Lee, A.S.; Onderwater, J.J.M.; Paton, J.C.; Paton, A.W.; Mommaas, A.M.; Kodach, L.L.; Hardwick, J.C.; Hommes, D.W.; Clevers, H.; Muncan, V. & Brink, G.R. van den (2013), ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response, Cell Reports 3(4): 1128-1139.
- Meij, T.G.J. de; Jharap, B.; Kneepkens, C.M.F.; Bodegraven, A.A. van; Boer, N.K.H. de & Dutch Initiative Crohn Colitis (2013), Long-term follow-up of children exposed intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease, Alimentary Pharmacology and Therapeutics 38(1): 38-43.
- Dop, W.A. van; Rosekrans, S.L.; Uhmann, A.; Jaks, V.; Offerhaus, G.J.A.; Weerman, M.A.V.; Kasper, M.; Heijmans, J.; Hardwick, J.C.H.; Verspaget, H.W.; Hommes, D.W.; Toftgard, R.; Hahn, H. & Brink, G.R. van den (2013), Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus, Gut 62(3): 348-357.
- Deen, W.K. van & Hommes, D.W. (2013), IBD Antibodies to anti-TNF therapy-consequences for IBD management, Nature Reviews Gastroenterology and Hepatology 10(8): 446-448.
- Molendijk I, Hommes DW & Duijvestein M (2013), Mesenchymal Stromal Cell Therapy in Crohn’s Disease.
- Heijmans, J.; Buller, N.V.J.A.; Hoff, E.; Dihal, A.A.; Poll, T. van der; Zoelen, M.A.D. van; Bierhaus, A.; Biemond, I.; Hardwick, J.C.H.; Hommes, D.W.; Muncan, V. & Brink, G.R. van den (2013), Rage signalling promotes intestinal tumourigenesis, Oncogene 32(9): 1202-1206.
- Strisciuglio, C.; Duijvestein, M.; Verhaar, A.P.; Vos, A.C.W.; Brink, G.R. van den; Hommes, D.W. & Wildenberg, M.E. (2013), Impaired autophagy leads to abnormal dendritic cell-epithelial cell interactions.
- Corstjens, P.L.A.M.; Fidder, H.H.; Wiesmeijer, K.C.; Dood, C.J. de; Rispens, T.; Wolbink, G.J.; Hommes, D.W. & Tanke, H.J. (2013), A rapid assay for on-site monitoring of infliximab trough levels: a feasibility study, Analytical and Bioanalytical Chemistry 405(23): 7367-7375.
- Schaik, F.D.M. van; Mooiweer, E.; Have, M. van der; Belderbos, T.D.G.; Kate, F.J.W. ten; Offerhaus, G.J.A.; Schipper, M.E.I.; Dijkstra, G.; Pierik, M.; Stokkers, P.C.F.; Ponsioen, C.; Jong, D.J. de; Hommes, D.W.; Bodegraven, A.A. van; Siersema, P.D.; Oijen, M.G.H. van; Oldenburg, B. & Dutch Initiative Crohn Colitis ICC (2013), Adenomas in Patients with Inflammatory Bowel Disease Are Associated with an Increased Risk of Advanced Neoplasia, Inflammatory Bowel Diseases 19(2): 342-349.
- Verhaar, A.P.; Wildenberg, M.E.; Duijvestein, M.; Vos, A.C.W.; Peppelenbosch, M.P.; Lowenberg, M.; Hommes, D.W. & Brink, G.R. van den (2013), Superantigen-Induced Steroid Resistance Depends on Activation of Phospholipase C beta 2, Journal of Immunology 190(12): 6589-6595.
- Deen, W.K. van; Oikonomopoulos, A. & Hommes, D.W. (2013), Stem cell therapy in inflammatory bowel disease: which, when and how?, Current Opinion in Gastroenterology 29(4): 384-390.
- Hennink, S.D.; Hofland, N.; Gopie, J.P.; Kaa, C. van der; Koning, K. de; Nielsen, M.; Tops, C.; Morreau, H.; Cappel, W.H.D.T.N.; Langers, A.M.J.; Hardwick, J.C.; Gaarenstroom, K.N.; Tollenaar, R.A.; Veenendaal, R.A.; Tibben, A.; Wijnen, J.; Heck, M. van; Asperen, C. van; Roukema, A.J.; Hommes, D.W.; Hes, F.J. & Vasen, H.F.A. (2013), Value-based healthcare in Lynch syndrome, Familial Cancer 12(2): 347-354.
- Verhaar, A.P.; Wildenberg, M.E.; Velde, A.A. te; Meijer, S.L.; Vos, A.C.W.; Duijvestein, M.; Peppelenbosch, M.P.; Hommes, D.W. & Brink, G.R. van den (2013), Miltefosine Suppresses Inflammation in a Mouse Model of Inflammatory Bowel Disease, Inflammatory Bowel Diseases 19(9): 1974-1982.
- Sandborn, W.J.; Gasink, C.; Gao, L.L.; Blank, M.A.; Johanns, J.; Guzzo, C.; Sands, B.E.; Hanauer, S.B.; Targan, S.; Rutgeerts, P.; Ghosh, S.; Villiers, W.J.S. de; Panaccione, R.; Greenberg, G.; Schreiber, S.; Lichtiger, S.; Feagan, B.G. & CERTIFI Study Grp (2012), Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease.
- Baan, B.; Dihal, A.A.; Hoff, E.; Bos, C.L.; Voorneveld, P.W.; Koelink, P.J.; Wildenberg, M.E.; Muncan, V.; Heijmans, J.; Verspaget, H.W.; Richel, D.J.; Hardwick, J.C.H.; Hommes, D.W.; Peppelenbosch, M.P. & Brink, G.R. van den (2012), 5-aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer, Gut 61(12): 1708-1715.
- Vos, A.C.W.; Wildenberg, M.E.; Arijs, I.; Duijvestein, M.; Verhaar, A.P.; Hertogh, G. de; Vermeire, E.; Rutgeerts, P.; Brink, G.R. van den & Hommes, D.W. (2012), Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro, Inflammatory Bowel Diseases 18(3): 401-408.
- Bokemeyer, B.; Hommes, D.; Gill, I.; Broberg, P. & Dignass, A. (2012), Mesalazine in left-sided ulcerative colitis: Efficacy analyses from the PODIUM trial on maintenance of remission and mucosal healing, Journal of Crohn's and Colitis 6(4): 476-482.
- Wildenberg, M.E.; Vos, A.C.W.; Wolfkamp, S.C.S.; Duijvestein, M.; Verhaar, A.P.; Velde, A.A. te; Brink, G.R. van den & Hommes, D.W. (2012), Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse, Gastroenterology 142(7): 1493-U189.
- Marel, S. van der; Majowicz, A.; Kwikkers, K.; Logtenstein, R. van; Velde, A.A. te; Groot, A.S. de; Meijer, S.L.; Deventer, S.J. van; Petry, H.; Hommes, D.W. & Ferreira, V. (2012), Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis, World Journal of Gastroenterology 18(32): 4288-4299.
- A. Inderson (2011), Viral infections in IBD.
- Strehl, C.; Gaber, T.; Lowenberg, M.; Hommes, D.W.; Verhaar, A.P.; Schellmann, S.; Hahne, M.; Fangradt, M.; Wagegg, M.; Hoff, P.; Scheffold, A.; Spies, C.M.; Burmester, G.R. & Buttgereit, F. (2011), Origin and functional activity of the membrane-bound glucocorticoid receptor, Arthritis and Rheumatism 63(12): 3779-3788.
- Hove, W.R. ten; Korkmaz, K.S.; Dries, S.O. den; Rooij, B.J.F. de; Hoek, B. van; Porte, R.J.; Reijden, J.J. van der; Coenraad, M.J.; Dubbeld, J.; Hommes, D.W. & Verspaget, H.W. (2011), Matrix metalloproteinase 2 genotype is associated with nonanastomotic biliary strictures after orthotopic liver transplantation.
- Vos, A.C.W.; Wildenberg, M.E.; Duijvestein, M.; Verhaar, A.P.; Brink, G.R. van den & Hommes, D.W. (2011), Anti-Tumor Necrosis Factor-alpha Antibodies Induce Regulatory Macrophages in an Fc Region-Dependent Manner, Gastroenterology 140(1): 221+.
- Nijmeijer, R.M.; Gadaleta, R.M.; Mil, S.W.C. van; Bodegraven, A.A. van; Crusius, J.B.A.; Dijkstra, G.; Hommes, D.W.; Jong, D.J. de; Stokkers, P.C.F.; Verspaget, H.W.; Weersma, R.K.; Woude, C.J. van der; Stapelbroek, J.M.; Schipper, M.E.I.; Wijmenga, C.; Erpecum, K.J. van; Oldenburg, B. & Dutch Initiative Crohn (2011), Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease, PLoS ONE 6(8).
- Heijmans, J.; Muncan, V.; Jacobs, R.J.; Jonge-Muller, E.S.M. de; Graven, L.; Biemond, I.; Ederveen, A.G.; Groothuis, P.G.; Mosselman, S.; Hardwick, J.C.; Hommes, D.W. & Brink, G.R. van den (2011), Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models, PLoS ONE 6(7).
- Reinisch, W.; Sandborn, W.J.; Hommes, D.W.; D'Haens, G.; Hanauer, S.; Schreiber, S.; Panaccione, R.; Fedorak, R.N.; Tighe, M.B.; Huang, B.; Kampman, W.; Lazar, A. & Thakkar, R. (2011), Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial, Gut 60(6): 780-787.
- Kodach, L.L.; Jacobs, R.J.; Voorneveld, P.W.; Wildenberg, M.E.; Verspaget, H.W.; Wezel, T. van; Morreau, H.; Hommes, D.W.; Peppelenbosch, M.P.; Brink, G.R. van den & Hardwick, J.C.H. (2011), Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway, Gut 60(11): 1544-1553.
- Festen, E.A.M.; Goyette, P.; Green, T.; Boucher, G.; Beauchamp, C.; Trynka, G.; Dubois, P.C.; Lagace, C.; Stokkers, P.C.F.; Hommes, D.W.; Barisani, D.; Palmieri, O.; Annese, V.; Heel, D.A. van; Weersma, R.K.; Daly, M.J.; Wijmenga, C. & Rioux, J.D. (2011), A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease, PLoS Genetics 7(1).
- Hommes, D.W.; Duijvestein, M.; Zelinkova, Z.; Stokkers, P.C.F.; Holsbergen-de Ley, M.; Stoker, J.; Voermans, C.; Oers, M.H.J. van & Kersten, M.J. (2011), Long-term follow-up of autologous hematopoietic stem cell transplantation for severe refractory Crohn's disease, Journal of Crohn's and Colitis 5(6): 543-549.
- Vasen, H.F.A.; Wasser, M.; Mil, A. van; Tollenaar, R.A.; Konstantinovski, M.; Gruis, N.A.; Bergman, W.; Hes, F.J.; Hommes, D.W.; Offerhaus, G.J.A.; Morreau, H.; Bonsing, B.A. & Cappel, W.H.D.T.N. (2011), Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation, Gastroenterology 140(3): 850-856.
- Marel, S. van der; Comijn, E.M.; Verspaget, H.W.; Deventer, S. van; Brink, G.R. van den; Petry, H.; Hommes, D.W. & Ferreira, V. (2011), Neutralizing Antibodies Against Adeno-associated Viruses in Inflammatory Bowel Disease Patients: Implications for Gene Therapy, Inflammatory Bowel Diseases 17(12): 2436-2442.
- Rooij, B.J.F. de; Beek, M.T. van der; Hoek, B. van; Vossen, A.C.T.M.; Hove, W.R. ten; Roos, A.; Schaapherder, A.F.; Porte, R.J.; Reijden, J.J. van der; Coenraad, M.J.; Hommes, D.W. & Verspaget, H.W. (2011), Mannose-binding lectin and Ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation, Journal of Hepatology 55(4): 800-807.
- Oostlander, A.E.; Bravenboer, N.; Sohl, E.; Holzmann, P.J.; Woude, C.J. van der; Dijkstra, G.; Stokkers, P.C.F.; Oldenburg, B.; Netelenbos, J.C.; Hommes, D.W.; Bodegraven, A.A. van; Lips, P. & Dutch Initiative Crohn Colitis ICC (2011), Histomorphometric Analysis Reveals Reduced Bone Mass and Bone Formation in Patients With Quiescent Crohn's Disease, Gastroenterology 140(1): 116-123.
- Baars, J.E.; Kuipers, E.J.; Dijkstra, G.; Hommes, D.W.; Jong, D.J. de; Stokkers, P.C.F.; Oldenburg, B.; Pierik, M.; Wahab, P.J.; Bodegraven, A.A. van; Woude, C.J. van der & Initiative Crohn & Colitis (2011), Malignant transformation of perianal and enterocutaneous fistulas is rare: results of 17 years of follow-up from The Netherlands, Scandinavian Journal of Gastroenterology 46(3): 319-325.
- D'Haens, G.R.; Panaccione, R.; Higgins, P.D.R.; Vermeire, S.; Gassull, M.; Chowers, Y.; Hanauer, S.B.; Herfarth, H.; Hommes, D.W.; Kamm, M.; Lofberg, R.; Quary, A.; Sands, B.; Sood, A.; Watermayer, G.; Lashner, B.; Lemann, M.; Plevy, S.; Reinisch, W.; Schreiber, S.; Siegel, C.; Targan, S.; Watanabe, M.; Feagan, B.; Sandborn, W.J.; Colombel, J.F. & Travis, S. (2011), The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD With the European Crohn's and Colitis Organization: When to Start, When to Stop, Which Drug to Choose, and How to Predict Response, American Journal of Gastroenterology 106(2): 199-212.
- Schaik, F.D.M. van; Kate, F.J.W. ten; Offerhaus, G.J.A.; Schipper, M.E.I.; Vleggaar, F.P.; Woude, C.J. van der; Stokkers, P.C.F.; Jong, D.J. de; Hommes, D.W.; Bodegraven, A.A. van; Siersema, P.D.; Oldenburg, B. & Dutch Initiative Crohn Colitis (2011), Misclassification of Dysplasia in Patients with Inflammatory Bowel Disease: Consequences for Progression Rates to Advanced Neoplasia, Inflammatory Bowel Diseases 17(5): 1108-1116.
- Pariente, B.; Cosnes, J.; Danese, S.; Sandborn, W.J.; Lewin, M.; Fletcher, J.G.; Chowers, Y.; D'Haens, G.; Feagan, B.G.; Hibi, T.; Hommes, D.W.; Irvine, E.J.; Kamm, M.A.; Loftus, E.V.; Louis, E.; Michetti, P.; Munkholm, P.; Oresland, T.; Panes, J.; Peyrin-Biroulet, L.; Reinisch, W.; Sands, B.E.; Schoelmerich, J.; Schreiber, S.; Tilg, H.; Travis, S.; Assche, G. van; Vecchi, M.; Mary, J.Y.; Colombel, J.F. & Lemann, M. (2011), Development of the Crohn's Disease Digestive Damage Score, the Lemann Score, Inflammatory Bowel Diseases 17(6): 1415-1422.
- Brakenhoff, L.K.P.M.; Heijde, D.M. van der & Hommes, D.W. (2011), IBD and arthropathies: a practical approach to its diagnosis and management, Gut 60(10): 1426-1435.
- Vos, A.C.W.; Bakkal, N.; Minnee, R.C.; Casparie, M.K.; Jong, D.J. de; Dijkstra, G.; Stokkers, P.; Bodegraven, A.A. van; Pierik, M.; Woude, C.J. van der; Oldenburg, B.; Hommes, D.W. & ICC (2011), Risk of Malignant Lymphoma in Patients with Inflammatory Bowel Diseases: A Dutch Nationwide Study, Inflammatory Bowel Diseases 17(9): 1837-1845.
- Horsthuis, K.; Ziech, M.L.W.; Bipat, S.; Spijkerboer, A.M.; Bruine-Dobben, A.C. de; Hommes, D.W. & Stoker, J. (2011), Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn's disease, Clinical Imaging 35(5): 360-365.
- Duijvestein, M.; Molendijk, I.; Roelofs, H.; Vos, A.C.W.; Verhaar, A.P.; Reinders, M.E.J.; Fibbe, W.E.; Verspaget, H.W.; Brink, G.R. van den; Wildenberg, M.E. & Hommes, D.W. (2011), Mesenchymal stromal cell function is not affected by drugs used in the treatment of inflammatory bowel disease, Cytotherapy 13(9): 1066-1073.
- Duijvestein, M.; Wildenberg, M.E.; Welling, M.M.; Hennink, S.; Molendijk, I.; Zuylen, V.L. van; Bosse, T.; Vos, A.C.W.; Jonge-Muller, E.S.M. de; Roelofs, H.; Weerd, L. van der; Verspaget, H.W.; Fibbe, W.E.; Velde, A.A.T.; Brink, G.R. van den & Hommes, D.W. (2011), Pretreatment with Interferon-gamma Enhances the Therapeutic Activity of Mesenchymal Stromal Cells in Animal Models of Colitis, STEM CELLS 29(10): 1549-1558.
- Dop, W.A. van; Marengo, S.; Velde, A.A. te; Ciraolo, E.; Franco, I.; Kate, F.J. ten; Boeckxstaens, G.E.; Hardwick, J.C.; Hommes, D.W.; Hirsch, E. & Brink, G.R. van den (2010), The absence of functional PI3K gamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice, Immunology Letters 131(1): 33-39.
- Koelink, P.J.; Hawinkels, L.J.A.C.; Wiercinska, E.; Sier, C.F.M.; Dijke, P. ten; Lamers, C.B.H.W.; Hommes, D.W. & Verspaget, H.W. (2010), 5-Aminosalicylic acid inhibits TGF-beta 1 signalling in colorectal cancer cells.
- Baert, F.; Moortgat, L.; Assche, G. van; Caenepeel, P.; Vergauwe, P.; Vos, M. de; Stokkers, P.; Hommes, D.; Rutgeerts, P.; Vermeire, S.; D'Haens, G.; Belgian Inflammatory Bowel Dis Res & N Holland Gut Club (2010), Mucosal Healing Predicts Sustained Clinical Remission in Patients With Early-Stage Crohn's Disease, Gastroenterology 138(2): 463-468.
- Fransen, K.; Visschedijk, M.C.; Sommeren, S. van; Fu, J.Y.Y.; Franke, L.; Festen, E.A.M.; Stokkers, P.C.F.; Bodegraven, A.A. van; Crusius, J.B.A.; Hommes, D.W.; Zanen, P.; Jong, D.J. de; Wijmenga, C.; Diemen, C.C. van & Weersma, R.K. (2010), Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease, Human Molecular Genetics 19(17): 3482-3488.
- Fidder, H.H. & Hommes, D.W. (2010), Anti-TNF and Crohn's Disease: When Should we Start?, Current Drug Targets 11(2): 143-147.
- Hanauer, S.B. & Hommes, D.W. (2010), Inflammatory bowel disease Foreword, Expert Review of Clinical Immunology 6(4): 499-500.
- Brakenhoff, L.K.P.M.; Heijde, D.M. van der; Hommes, D.W.; Huizinga, T.W.J. & Fidder, H.H. (2010), The joint-gut axis in inflammatory bowel diseases, Journal of Crohn's and Colitis 4(3): 257-268.
- Rooij, B.J.F. de; Hoek, B. van; Hove, W.R. ten; Roos, A.; Bouwman, L.H.; Schaapherder, A.F.; Porte, R.J.; Daha, M.R.; Reijden, J.J. van der; Coenraad, M.J.; Ringers, J.; Baranski, A.G.; Hepkema, B.G.; Hommes, D.W. & Verspaget, H.W. (2010), Lectin Complement Pathway Gene Profile of Donor and Recipient Determine the Risk of Bacterial Infections After Orthotopic Liver Transplantation, Hepatology 52(3): 1100-1110.
- Kodach, L.L.; Jacobs, R.J.; Heijmans, J.; Noesel, C.J.M. van; Langers, A.M.J.; Verspaget, H.W.; Hommes, D.W.; Offerhaus, G.J.A.; Brink, G.R. van den & Hardwick, J.C.H. (2010), The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer, Carcinogenesis 31(9): 1567-1575.
- Baumgart, D.C.; Targan, S.R.; Dignass, A.U.; Mayer, L.; Assche, G. van; Hommes, D.W.; Hanauer, S.B.; Mahadevan, U.; Reinisch, W.; Plevy, S.E.; Salzberg, B.A.; Buchman, A.L.; Mechkov, G.M.; Krastev, Z.A.; Lowder, J.N.; Frankel, M.B. & Sandborn, W.J. (2010), Prospective Randomized Open-label Multicenter Phase I/II Dose Escalation Trial of Visilizumab (HuM291) in Severe Steroid-refractory Ulcerative Colitis, Inflammatory Bowel Diseases 16(4): 620-629.
- Festen, E.A.M.; Stokkers, P.C.F.; Diemen, C.C. van; Bodegraven, A.A. van; Boezen, H.M.; Crusius, B.J.A.; Hommes, D.W.; Woude, J.C. van der; Balschun, T.; Verspaget, H.W.; Schreiber, S.; Jong, D.J. de; Franke, A.; Dijkstra, G.; Wijmenga, C. & Weersma, R.K. (2010), Genetic Analysis in A Dutch Study Sample Identifies More Ulcerative Colitis Susceptibility Loci and Shows Their Additive Role in Disease Risk, American Journal of Gastroenterology 105(2): 395-402.
- Dignass, A.; Assche, G. van; Lindsay, J.O.; Lemann, M.; Soderholm, J.; Colombel, J.F.; Danese, S.; D'Hoore, A.; Gassull, M.; Gomollon, F.; Hommes, D.W.; Michetti, P.; O'Morain, C.; Oresland, T.; Windsor, A.; Stange, E.F.; Travis, S.P.L. & ECCO (2010), The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management, Journal of Crohn's and Colitis 4(1): 28-62.
- McGovern, D.P.B.; Gardet, A.; Torkvist, L.; Goyette, P.; Essers, J.; Taylor, K.D.; Neale, B.M.; Ong, R.T.H.; Lagace, C.; Li, C.; Green, T.; Stevens, C.R.; Beauchamp, C.; Fleshner, P.R.; Carlson, M.; D'Amato, M.; Halfvarson, J.; Hibberd, M.L.; Lordal, M.; Padyukov, L.; Andriulli, A.; Colombo, E.; Latiano, A.; Palmieri, O.; Bernard, E.J.; Deslandres, C.; Hommes, D.W.; Jong, D.J. de; Stokkers, P.C.; Weersma, R.K.; Sharma, Y.; Silverberg, M.S.; Cho, J.H.; Wu, J.; Roeder, K.; Brant, S.R.; Schumm, L.P.; Duerr, R.H.; Dubinsky, M.C.; Glazer, N.L.; Haritunians, T.; Ippoliti, A.; Melmed, G.Y.; Siscovick, D.S.; Vasiliauskas, E.A.; Targan, S.R.; Annese, V.; Wijmenga, C.; Pettersson, S.; Rotter, J.I.; Xavier, R.J.; Daly, M.J.; Rioux, J.D.; Seielstad, M. & NIDDK IBD Genetics Consortium (2010), Genome-wide association identifies multiple ulcerative colitis susceptibility loci, Nature Genetics 42(4): 332U88.
- Koelink, P.J.; Mieremet-Ooms, M.A.C.; Corver, W.E.; Wolanin, K.; Hommes, D.W.; Lamers, C.B.H.W. & Verspaget, H.W. (2010), 5-Aminosalicylic Acid Interferes in the Cell Cycle of Colorectal Cancer Cells and Induces Cell Death Modes, Inflammatory Bowel Diseases 16(3): 379-389.
- Dubbeld, J.; Hoekstra, H.; Farid, W.; Ringers, J.; Porte, R.J.; Metselaar, H.J.; Baranski, A.G.; Kazemier, G.; Bere, A.P. van den & Hoek, B. van (2010), Similar liver transplantation survival with selected cardiac death donors and brain death donors, British Journal of Surgery 97(5): 744-753.
- Wassenaar, M.J.E.; Cazemier, M.; Biermasz, N.R.; Pereira, A.M.; Roelfsema, F.; Smit, J.W.A.; Hommes, D.W.; Felt-Bersma, R.J.F. & Romijn, J.A. (2010), Acromegaly Is Associated with an Increased Prevalence of Colonic Diverticula: A Case-Control Study, Journal of Clinical Endocrinology and Metabolism 95(5): 2073-2079.
- Dotan, I.; Rachmilewitz, D.; Schreiber, S.; Eliakim, R.; Woude, C.J. van der; Kornbluth, A.; Buchman, A.L.; Bar-Meir, S.; Bokemeyer, B.; Goldin, E.; Maaser, C.; Mahadevan, U.; Seidler, U.; Hoffman, J.C.; Homoky, D.; Plasse, T.; Powers, B.; Rutgeerts, P.; Hommes, D. & Semapimod-CD04 CD05 Investigators (2010), A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease, Gut 59(6): 760-766.
- Rijnierse, A.; Redegeld, F.A.; Blokhuis, B.R.; Heijden, M.W. van der; Velde, A.A.T.; Pronk, I.; Hommes, D.W.; Nijkamp, F.P.; Koster, A.S. & Kraneveld, A.D. (2010), Ig-Free Light Chains Play a Crucial Role in Murine Mast Cell-Dependent Colitis and Are Associated with Human Inflammatory Bowel Diseases, Journal of Immunology 185(1): 653-659.
- Woude, C.J. van der; Stokkers, P.; Bodegraven, A.A. van; Assche, G. van; Hebzda, Z.; Paradowski, L.; D'Haens, G.; Ghosh, S.; Feagan, B.; Rutgeerts, P.; Dijkstra, G.; Jong, D.J. de; Oldenburg, B.; Farhan, M.; Richard, T.; Dean, Y.; Hommes, D.W. & ICC (2010), Phase I, Double-blind, Randomized, Placebo-controlled, Dose-escalation Study of NI-0401 (a Fully Human Anti-CD3 Monoclonal Antibody) in Patients with Moderate to Severe Active Crohn's Disease, Inflammatory Bowel Diseases 16(10): 1708-1716.
- Sandborn, W.J.; Colombel, J.F.; Frankel, M.; Hommes, D.; Lowder, J.N.; Mayer, L.; Plevy, S.; Stokkers, P.; Travis, S.; Assche, G. van; Baumgart, D.C. & Targan, S.R. (2010), Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis, Gut 59(11): 1485-1492.
- Dop, W.A. van; Heijmans, J.; Buller, N.V.J.A.; Snoek, S.A.; Rosekrans, S.L.; Wassenberg, E.A.; Weerman, M.A.V.; Lanske, B.; Clarke, A.R.; Winton, D.J.; Wijgerde, M.; Offerhaus, G.J.; Hommes, D.W.; Hardwick, J.C.; Jonge, W.J. de; Biemond, I. & Brink, G.R. van den (2010), Loss of Indian Hedgehog Activates Multiple Aspects of a Wound Healing Response in the Mouse Intestine, Gastroenterology 139(5): 1665+.
- Duijvestein, M.; Vos, A.C.W.; Roelofs, H.; Wildenberg, M.E.; Wendrich, B.B.; Verspaget, H.W.; Kooy-Winkelaar, E.M.C.; Koning, F.; Zwaginga, J.J.; Fidder, H.H.; Verhaar, A.P.; Fibbe, W.E.; Brink, G.R. van den & Hommes, D.W. (2010), Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study, Gut 59(12): 1662-1669.
- Weersma RK, Stokkers PCF, van Bodegraven AA, van Hogezand RA, Verspaget HW, de Jong DJ, van der Woude CJ, Oldenburg B, Linskens RK & Festen EAM (2009), Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort, Gut 58(3): 388-395.
- Cappel WHDTN, Langers AMJ & Hommes DW (2009), First endoscopic appearance of ulcerative colitis, Journal of Crohn's and Colitis 3(1): 42-43.
- Koelink PJ, Robanus-Maandag EC, Devilee P, Hommes DW, Lamers CBHW & Verspaget HW (2009), 5-Aminosalicylic acid inhibits colitis-associated but not sporadic colorectal neoplasia in a novel conditional Apc mouse model, Carcinogenesis 30(7): 1217-1224.
- Hawinkels LJAC, Verspaget HW, van der Reijden JJ, van der Zon JM, Verheijen JH, Hommes DW, Lamers CBHW & Sier CFM (2009), Active TGF-beta 1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence, Cancer Science 100(4): 663-670.
- Van den Brande JMH, Hommes DW & Peppelenbosch MP (2009), A possible link between TIMP-1 induction and response to infliximab Response, Gut 58(6): 888-889.
- Koelink PJ, Lamers CBHW, Hommes DW & Verspaget HW (2009), Circulating cell death products predict clinical outcome of colorectal cancer patients, BMC Cancer 9.
- Koelink PJ, Sier CFM, Hommes DW, Lamers CBHW & Verspaget HW (2009), Clinical significance of stromal apoptosis in colorectal cancer, British Journal of Cancer 101(5): 765-773.
- Lutgens MWMD, Oldenburg B, Siersema PD, van Bodegraven AA, Dijkstra G, Hommes DW, de Jong DJ, Stokkers PCF, van der Woude CJ & Vleggaar FP (2009), Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease, British Journal of Cancer 101(10): 1671-1675.
- van Dop WA, Uhmann A, Wijgerde M, Sleddens-Linkels E, Heijmans J, Offerhaus GJ, Weerman MAV, Boeckxstaens GE, Hommes DW, Hardwick JC, Hahn H & van den Brink GR (2009), Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway, Gastroenterology 136(7): 2195-2203.
- Claessen MMH, Lutgens MWMD, van Buuren HR, Oldenburg B, Stokkers PCF, van der Woude CJ, Hommes DW, de Jong DJ, Dijkstra G, van Bodegraven AA, Siersema PD & Vleggaar FP (2009), More Right-sided IBD-associated Colorectal Cancer in Patients with Primary Sclerosing Cholangitis, Inflammatory Bowel Diseases 15(9): 1331-1336.
- van Schaik FDM, Vleggaar FP, Offerhaus GJA, Schipper MEI, Stokkers PCF, van der Woude CJ, Hommes DW, van Bodegraven AA, Siersemaa PD & Oldenburg B (2009), Progression rate of flat low-grade dysplasia to advanced neoplasia in IBD, European Journal of Gastroenterology and Hepatology 21(3): A77A77.
- van der Marel S, Duijvestein M, Hardwick JC, van den Brink GR, Veenendaal R, Hommes DW & Fidder HH (2009), Quality of Web-based Information on Inflammatory Bowel Diseases, Inflammatory Bowel Diseases 15(12): 1891-1896.
- Hommes DW (2009), Risks and Benefits of Biologic Therapy for IBD, Journal of Pediatric Gastroenterology and Nutrition 48: S52S53.
- Wassenaar MJE, Biermasz NR, Pereira AM, van der Klaauw AA, Smit JWA, Roelfsema F, van der Straaten T, Cazemier M, Hommes DW, Kroon HM, Kloppenburg M, Guchelaar HJ & Romijn JA (2009), The Exon-3 Deleted Growth Hormone Receptor Polymorphism Predisposes to Long-Term Complications of Acromegaly, Journal of Clinical Endocrinology and Metabolism 94(12): 4671-4678.
- Noomen CG, Hommes DW & Fidder HH (2009), Update on genetics in inflammatory disease, Best Practice and Research: Clinical Gastroenterology 23(2): 233-243.
- Meijer MJ, Mieremet-Ooms MAC, Sier CFM, van Hogezand RA, Lamers CBHW, Hommes DW & Verspaget HW (2009), Matrix Metalloproteinases and Their Tissue Inhibitors as Prognostic Indicators for Diagnostic and Surgical Recurrence in Crohn's Disease, Inflammatory Bowel Diseases 15(1): 84-92.
- Parikh K, Diks SH, Tuynman JHB, Verhaar A, Lowenberg M, Hommes DW, Joore J, Pandey A & Peppelenbosch MP (2009), Comparison of Peptide Array Substrate Phosphorylation of c-Raf and Mitogen Activated Protein Kinase Kinase Kinase 8, PLoS ONE 4(7).
- Kok K, Nock GE, Verrall EAG, Mitchell MP, Hommes DW, Peppelenbosch MP & Vanhaesebroeck B (2009), Regulation of p110 delta PI 3-Kinase Gene Expression, PLoS ONE 4(4).
- D'Haens G, Baert F, van Assche G, Caenepeel P, Vergauwe P, Tuynman H, De Vos M, van Deventer S, Stitt L, Donner A, Vermeire S, Van De Mierop FJ, Coche JCR, van der Woude J, Ochsenkuhn T, van Bodegraven AA, van Hootegem PP, Lambrecht GL, Mana F, Rutgeerts P, Feagan BG & Hommes D (2008), Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial, Lancet 371(9613).
- Hawinkels LJAC, Zuidwijk K, Verspaget HW, de Jonge-Muller ESM, van Duijn W, Ferreira V, Fontijn RD, David G, Hommes DW, Lamers CBHW & Sier CFM (2008), VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis, European Journal of Cancer 44(13).
- Hommes DW, Erkelens W, Ponsioen C, Stokkers P, Raws E, van der Spek M, Ten Kate F & van Deventer SJ (2008), A double-blind, placebo-controlled, randomized study of infliximab in primary sclerosing cholangitis, Journal of Clinical Gastroenterology 42(5).
- Eshuis EJ, Polle SW, Slors JF, Hommes DW, Sprangers MAG, Gouma DJ & Bemelman WA (2008), Long-term surgical recurrence, morbidity, quality of life, and body image of laparoscopic-assisted vs. open ileocolic resection for Crohn's disease: A comparative study, Diseases of the Colon and Rectum 51(6).
- Lowenberg M, Stahn C, Hommes DW & Buttgereit F (2008), Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands, Steroids 73(9-10).
- Langers P, Press RR, den Hartigh J, Cremers SCLM, Baranski AG, Lamers CBHW, Hommes DW & van Hoek B (2008), Flexible limited sampling model for monitoring tacrolimus in stable patients having undergone liver transplantation with samples 4 to 6 hours after dosing is superior to trough concentration, Therapeutic Drug Monitoring 30(4).
- Lutgens MWMD, Vleggaar FP, Schipper MEI, Stokkers PCF, van der Woude CJ, Hommes DW, de Jong DJ, Dijkstra G, van Bodegraven AA, Oldenburg B & Samsom M (2008), High frequency of early colorectal cancer in inflammatory bowel disease, Gut 57(9).
- Kodach LL, Bleurning SA, Musler AR, Peppelenbosch MR, Hommes DW, van Den Brink GR, van Noesel CJM, Offerhaus GJA & Hardwick JCH (2008), The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer, Cancer 112(2).
- Zelinkova Z, van Beelen AJ, de Kort F, Moerland PD, van Themaat EVL, Velde AAT, van Deventer SJ, de Jong EC & Hommes DW (2008), Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn's disease patient-derived dendritic cells, Inflammatory Bowel Diseases 14(2).
- Kodach LL, Wiercinska E, De Miranda NFCC, Bleuming SA, Musler AR, Peppelenbosch MP, Dekker E, van den Brink GR, Van Noesel CJM, Morreau H, Hommes DW, Ten Dijke P, Offerhaus GJA & Hardwick JCH (2008), The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers, Gastroenterology 134(5).
- Derijks LJJ, van Helden RB, Hommes DW & Stokkers PC (2008), Dosing azathioprine in thiopurine S-methyltransferase deficient inflammatory bowel disease patients, Gut 57(6).
- Langers AMJ, Sier CFM, Hawinkels LJAC, Kubben FJGM, van Duijn W, van der Reijden JJ, Lamers CBHW, Hommes DW & Verspaget HW (2008), MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not, British Journal of Cancer 98(11).
- Duijvestein M, van den Brink GR & Hommes DW (2008), Stem cells as potential novel therapeutic strategy for inflammatory bowel disease, Journal of Crohn's and Colitis 2(2): 99-106.
- Hawinkels LJ, Zuidwijk K, Verspaget HW, de Jonge-Muller ES, van Duijn W, Ferreira V, Fontijn RD, David G, Hommes DW, Lamers CB & Sier CF (2008), VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.
- Stange EF, Travis SPL, Vermeire S, Reinisch W, Geboes K, Barakauskiene A, Feakins R, Flejou JF, Herfarth H & Hommes DW (2008), European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis, Journal of Crohn's and Colitis 2(1): 1-23.
- Ley M. de, Vos R. de, Hommes D.W. & Stokkers P.C.F. (2007), Fish oil for induction of remission in ulcerative colitis, Cochrane Database of Systematic Reviews (4): CD005986.
- Meijer MJW, Mieremet-Ooms MAC, Hogezand RA, Lamers CBHW, Hommes DW & Verspaget HW (2007), Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease, World Journal of Gastroenterology 13(21).
- Kodach LL, Bleuming SA, Peppelenbosch MP, Hommes DW, Van Den Brink GR & Hardwick JCH (2007), The effect of statins in colorectal cancer is mediated through the bone morphogenetic protein pathway, Gastroenterology 133(4).
- Velde AAT, de Kort F, Sterrenburg E, Pronk I, ten Kate FJW, Hommes DW & van Deventer SJH (2007), Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease, Inflammatory Bowel Diseases 13(3).
- Lowenberg M, Verhaar AP, van den Brink GR & Hommes DW (2007), Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression, Trends in Molecular Medicine 13(4).
- Scarpa M, van Koperen PJ, Ubbink DT, Hommes DW, ten Kate FJW & Bemelman WA (2007), Systematic review of dysplasia after restorative proctocolectomy for ulcerative colitis, British Journal of Surgery 94(5).
- de Ridder L, Benninga MA, Taminiau JAJM & Hommes DW (2007), Infliximab at diagnosis: A sledgehammer to crack a walnut? Authors' response to letter, Journal of Pediatric Gastroenterology and Nutrition 45(1).
- van der Woude CJ & Hommes DW (2007), Biologics in Crohn's disease: searching indicators for outcome, Expert Opinion on Biological Therapy 7(8).
- Stahn C, Lowenberg M, Hommes DW & Buttgereit F (2007), Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists, Molecular and Cellular Endocrinology 275(1-2).
- De Ley M, de Vos R, Hommes DW & Stokkers P (2007), Fish oil for induction of remission in ulcerative colitis, Cochrane Database of Systematic Reviews.
- Teml A, Schwab M, Hommes DW, Almer S, Lukas M, Feichtenschlager T, Florin T, Seiderer J, Petritsch W, Bokemeyer B, Kreisel W, Herrlinger KR, Knoflach P, Bonaz B, Klugmann T, Herfarth H, Pedarnig N & Reinisch W (2007), A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease, Wiener Klinische Wochenschrift 119(17-18).
- Langers P, Cremers SCLM, den Hartigh J, Rijnbeek EMT, Ringers J, Lamers CBHW, Hommes DW & van Hoek B (2007), Individualized population pharmacokinetic model with limited sampling for cyclosporine monitoring after liver transplantation in clinical practice, Alimentary Pharmacology and Therapeutics 26(10).
- Plevy S, Salzberg B, Van Assche G, Regueiro M, Hommev D, Sandborn W, Hanauer S, Targan S, Mayer L, Mahadevan U, Frankel M & Lowder J (2007), A phase I study of visilizumab a humanized anti-CD3, monoclonal antibody, in severe steroid-refractory ulcerative colitis, Gastroenterology 133(5).
- Meijer MJW, Mieremet-Ooms MAC, van der Zon AM, van Duijn W, van Hogezand RA, Sier CFM, Hommes DW, Lamers CBHW & Verspaget HW (2007), Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype, Digestive and Liver Disease 39(8).
- Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, ten Kate FJ, van Deventer SJH, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li LH & van den Brink GR (2007), Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice, Cancer Research 67(17).
- de Ridder L, Weersm RK, Dijkstra G, van der Steege G, Benninga MA, Nolte IM, Taminiau JAJM, Hommes DW & Stokkers PCF (2007), Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's disease, Inflammatory Bowel Diseases 13(9).
- Hawinkels LJAC, Verspaget HW, van Duijn W, van der Zon JM, Zuidwijk K, Kubben FJGM, Verheijen JH, Hommes DW, Lamers CBHW & Sier CF (2007), Tissue level, activation and cellular localisation of TGF-beta 1 and association with survival in gastric cancer patients, British Journal of Cancer 97(3).
- Maartense S, Dunker MS, Slors JFM, Cuesta MA, Pierik EGJM, Gouma DJ, Hommes DW, Sprangers MA & Bemelman WA (2006), Laparoscopic-Assisted versus open ileocolic resection for Crohn's disease - A randomized trial, Annals of Surgery 243(2).
- Holtmann MH, Krummenauer F, Claas C, Kremeyer K, Lorenz D, Rainer O, Vogel I, Bocker U, Bohm S, Buning C, Duchmann R, Gerken G, Herfarth H, Lugering N, Kruis W, Reinshagen M, Schmidt J, Stallmach A, Stein J, Sturm A, Galle PR, Hommes DW, D'Haens G, Rutgeerts P & Neurath MF (2006), Long-term effectiveness of azathioprine in IBD beyond 4 years: A European multicenter study in 1176 patients, Digestive Diseases and Sciences 51(9).
- Egan LJ, Derijks LJJ & Hommes DW (2006), Pharmacogenomics in inflammatory bowel disease, Clinical Gastroenterology and Hepatology 4(1).
- Zelinkova Z, Derijks LJJ, Stokkers PCF, Vogels EWM, van Kampen AHC, Curvers WL, Cohn D, van Deventer SJH & Hommes DW (2006), Inosine triphosphate pyrophosphatase and thiopurine S-methyltransferase genotypes relationship to azathioprine-induced myelosuppression, Clinical Gastroenterology and Hepatology 4(1).
- Derijks LJJ, Gilissen LPL, Engels LGJB, Bos LP, Bus PJ, Lohman JJHM, van Deventer SJH, Hommes DW & Hooymans PM (2006), Pharmacokinetics of 6-thioguanine in patients with inflammatory bowel disease, Therapeutic Drug Monitoring 28(1).
- Stokkers PCF, Deley M, Van Der Spek M, Verberne HJ, Van Deventer SJH & Hommes DW (2006), Intravenous pamidronate in combination with calcium and vitamin D: Highly effective in the treatment of low bone mineral density in inflammatory bowel disease, Scandinavian Journal of Gastroenterology 41(2).
- Caprilli R, Gassull MA, Escher JC, Moser G, Munkholm P, Forbes A, Hommes DW, Lochs H, Angelucci E, Cocco A, Vucelic B, Hildebrand H, Kolacek S, Riis L, Lukas M, de Franchis R, Hamilton M, Jantschek G, Michetti P, O'Morain C, Anwar MM, Freitas JL, Mouzas IA, Baert F, Mitchel R & Hawkey CJ (2006), European evidence based consensus on the diagnosis and management of Crohn's disease: special situations, Gut 55.
- Hendriks, Y.M.C.; Jagmohan-Changur, S.; Klift, H.M. van der; Morreau, H.; Puijenbroek, M. van; Tops, C.; Os, T. van; Wagner, A.; Ausems, M.G.F.M.; Gomez, E.; Breuning, M.H.; Brocker-Vriends, A.H.J.T.; Vasen, H.F.A. & Wijnen, J.T. (2006), Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome), Gastroenterology 130(2).
- Jong, A.E. de; Hendriks, Y.M.C.; Kleibeuker, J.H.; Boer, S.Y. de; Cats, A.; Griffioen, G.; Nagengast, F.M.; Nelis, F.G.; Rookus, M.A. & Vasen, H.F.A. (2006), Decrease in mortality in Lynch syndrome families because of surveillance, Gastroenterology 130(3).
- Park JG, Kim DW, Hong CW, Nam BH, Shin YK, Hong SH, Kim IJ, Lim SB, Aronson M, Bisgaard ML, Brown GJ, Burn J, Chow E, Conrad P, Douglas F, Dunlop M, Ford J, Greenblatt MS, Heikki J, Heinimann K, Lynch EL, Macrae F, McKinnon WC, Moeslein G, Rossi BM, Rozen P, Schofield L, Vaccaro C, Vasen H, Velthuizen M, Viel A & Wijnen J (2006), Germ line mutations of mismatch repair genes in hereditary nonpolyposis colorectal cancer patients with small bowel cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study, Clinical Cancer Research 12(11).
- Polle SW, Wind J, Ubbink DT, Hommes DW, Gouma DJ & Bemelman WA (2006), Short-term outcomes after laparoscopic ileocolic resection for Crohn's disease, Digestive Surgery 23(5-6).
- Dove-Edwin, I.; Jong, A.E. de; Adams, J.; Mesher, D.; Lipton, L.; Sasieni, P.; Vasen, H.F.A. & Thomas, H.J.W. (2006), Prospective results of surveillance colonoscopy in dominant familial colorectal cancer with and without Lynch syndrome, Gastroenterology 130(7).
- Braat H, Rottiers P, Hommes DW, Huyghebaert N, Remaut E, Remon JP, Van Deventer SJH, Neirynck S, Peppelenbosch MP & Steidler L (2006), A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease, Clinical Gastroenterology and Hepatology 4(6).
- Hommes DW, Mikhajlova TL, Stoinov S, Stimac D, Vucelic B, Lonovics J, Zakuciova M, D'Haens G, Van Assche G, Ba S, Lee S & Pearce T (2006), Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease, Gut 55(8).
- Reinisch W, Hommes DW, Van Assche G, Colombel JF, Gendre JP, Oldenburg B, Teml A, Geboes K, Ding H, Zhang L, Tang M, Cheng M, van Deventer SJH, Rutgeerts P & Pearce T (2006), A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn's disease, Gut 55(8).
- van Gemert-Horsthuis K, Florie J, Hommes DW, Lavini C, Reitsma JB, van Deventer SJ & Stoker J (2006), Feasibility of evaluating Crohn's disease activity at 3.0 Tesla, Journal of Magnetic Resonance Imaging 24(2).
- Hommes DW, Oldenburg B, van Bodegraven AA, van Hogezand RA, de Jong DJ, Romberg-Camps MJL, van der Woude J & Dijkstra G (2006), Guidelines for treatment with infliximab for Crohn's disease, Netherlands Journal of Medicine 64(7).
- D'Haens G, Hommes D, Engels L, Baert F, Van der Waaij L, Connor P, Ramage J, Dewit O, Palmen M, Stephenson D & Joseph R (2006), Once daily MMX mesalazine for the treatment of mild-to-moderate ulcerative colitis: a phase II, dose-ranging study, Alimentary Pharmacology and Therapeutics 24(7).
- Velde AAT, Verstege MI & Hommes DW (2006), Critical appraisal of the current practice in murine TNBS-induced colitis, Inflammatory Bowel Diseases 12(10).
- Braat H, Peppelenbosch MP & Hommes DW (2006), Immunology of Crohn's disease, Annals of the New York Academy of Sciences 1072.
- Jong, A.E. de; Nagengast, F.M.; Kleibeuker, J.H.; Meeberg, P.C. van de; Wijk, H.J. van; Cats, A.; Griffioen, G. & Vasen, H.F.A. (2006), What is the appropriate screening protocol in Lynch syndrome?, Familial Cancer 5(4).
- Verstege MI, Velde AAT & Hommes DW (2006), Apoptosis as a therapeutic paradigm in inflammatory bowel diseases, Acta Gastroenterologica Belgica 69(4).
- Jong, A.E. de & Vasen, H.F.A. (2006), The frequency of a positive family history for colorectal cancer: a population-based study in the Netherlands, Netherlands Journal of Medicine 64(10).
- Lowenberg M, Verhaar AP, Bilderbeek J, van Marle J, Buttgereit F, Peppelenbosch MP, van Deventer SJ & Hommes DW (2006), Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN, EMBO Reports 7(10).
- Lowenberg M, Peppelenbosch M & Hommes D (2006), Biological therapy in the management of recent-onset Crohn's disease, Drugs 66(11).
- de Ridder L, Benninga MA, Taminiau JAJM & Hommes DW (2006), Infliximab as first-line therapy in severe pediatric Crohn disease, Journal of Pediatric Gastroenterology and Nutrition 43(3).
- Derijks LJJ, Gilissen LPL, Hooymans PM & Hommes DW (2006), Review article: thiopurines in inflammatory bowel disease, Alimentary Pharmacology and Therapeutics 24(5).
- Hendriks, Y.M.C.; Jong, A.E. de; Morreau, H.; Tops, C.M.J.; Vasen, H.F.; Wijnen, J.T.; Breuning, M.H. & Brocker-Vriends, A.H.J.T. (2006), Diagnostic approach and management of Lynch syndrome (Hereditary Nonpolyposis Colorectal Carcinoma): A guide for clinicians, CA: A Cancer Journal for Clinicians 56(4).
- Lowenberg M, Scheffer M, Verhaar A, Peppelenbosch M & Hommes D (2006), A role for STAT5 in steroid-resistant UC?, Inflammatory Bowel Diseases 12(7).
- Loewenberg M, Tuynman J, Scheffer M, Verhaar A, Vermeulen L, van Deventer S, Hommes D & Peppelenbosch M (2006), Kinome analysis reveals nongenomic glucocorticoid receptor-dependent inhibition of insulin signaling, Endocrinology 147(7).
- De Ridder L, van Dieren JM, van Deventer HJH, Stokkers PCF, van der Woude JCJ, van Vuuren AJ, Benninga MA, Escher JC & Hommes DW (2006), Pharmacogenetics of thiopurine therapy in paediatric IBD patients, Alimentary Pharmacology and Therapeutics 23(8).
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