Leiden Academic Centre for Drug Research
Honorary symposium Prof. dr. M. Danhof: Four decades of Research in Pharmacokinetics, Pharmacodynamics and beyond...", Leiden, 31 March 2017
About this symposium:
This 'Farewell symposium' will celebrate Prof. dr. M. Danhof's professional career and all the high level contributions he has made to the area of Pharmacology. The symposium will be followed by the farewell lecture of Professor Danhof and a reception.
List of Participants - 31 March 2017
- HONORARY SYMPOSIUM "Four decades of Research in Pharmocokinetics, Pharmacodynamics and beyond…" [pdf]
The symposium and farewell lecture require seperate registration each:
Registration for the Farewell Lecture 16:00 - 17:00, 'Academiegebouw'
Registration is free of charge.
The registration for the symposium is closed.
In the case you are unfortunately not be able to attend the symposium after registration, please let us know!
Symposium Program, Stadsgehoorzaal
Prof. dr. Douwe Breimer - Leiden University, NL
Prof. dr. Catherijne Knibbe - Antonious Hospital Nieuwegein / Leiden University, NL
09:00 - 09:30 Welcome with coffee & tea at "Stadsgehoorzaal"
09:30 - 09:40 Introduction pharmacokinetics - pharmacodynamics research at Leiden University
Douwe Breimer - Leiden University, NL
09:40 - 10:00 Pharmacokinetics: from physiologically-based models to compartmental models and back!
Amin Rostami - University of Manchester, UK
10:00 - 10:20 Targeting the CNS; translational research approaches
Elizabeth de Lange - Leiden University, NL
10:20 - 10:40 Measuring and modeling pharmacological drug effect: Mission Accomplished!!!
Don Stanski - AstraZeneca, USA
10:40 - 11:10 COFFEE BREAK
11:10 - 11:30 Quantitative translational pharmacology: connecting pharmacokinetics, dynamics and receptor theory
Piet Hein van der Graaf - Leiden University, NL/Certara, UK
11:30 - 11:50 Drug development as easy as (phase) I II III IV ? Time for disruption!
Adam Cohen - Center for Human Drug Research (CHDR), NL
11:50 - 12:10 Drug action in developing biological systems- clinical pharmacology in pediatrics
Sander Vinks - University of Cincinnati, USA
12:10 - 13:30 LUNCH
13:30 - 13:50 Disease and disease progression
Nick Holford - University of Auckland NZL
13:50 - 14:10 Open innovation: towards the sharing of data, models and workflows
Mats Karlsson - Uppsala University, SWE
14:10 - 14:30 Towards systems pharmacology
Don Mager - University of Buffalo, USA
14:30 - 14:50 Precision medicine in clinical practice
Henk Jan Guchelaar - Leiden University Medical Center (LUMC), NL
14:50 - 15:15 COFFEE BREAK
Farewell Lecture, 'Academiegebouw'
15:15 - 15:45 Walk to "Academiegebouw"
16:00 - 17:00 Farewell Lecture: Reflections on pharmacology - Four decades of pharmacokinetics-pharmacodynamics research at Leiden University
17:00 - 18:30 Reception
For questions: firstname.lastname@example.org
Reflections on pharmacology: 'Pharmacokinetics & Pharmacodynamics' en route to 'Systems Pharmacology'
Over the years pharmacology has contributed important pharmacokinetic (PK) and pharmacodynamic (PD) modeling concepts that are widely utilized in drug discovery & development research and in clinical practice. At this symposium we will review the established as well as the emerging novel concepts in pharmacology.
At the level of the pharmacodynamics, between 1960 to 1970, the development of receptor theory concepts has yielded the basis for the understanding of in vivo drug-concentration-effect relations. Next, in particular progress in the pharmacokinetics has been the source of novel concepts. Major achievements in pharmacokinetics include:
- the elucidation of the molecular mechanisms of drug disposition (i.e. drug metabolizing enzymes and transporters),
- the development of pharmacokinetic modeling concepts including the introduction of physiology-based pharmacokinetic (PBPK) modeling for the prediction of in vivo drug concentration profiles,
- the identification of inter-individual variation in drug disposition as the basis for variation in drug response (and the introduction of the concepts of â€œpopulationâ€ pharmacokinetics), and
- the introduction of pharmacokinetic-pharmacodynamic modeling (PKPD) concepts as the basis for prediction of the time course of drug effects.
Nowadays pharmacokinetic and pharmacodynamic modeling concepts are routinely used as the basis for the development of new drugs. Moreover PKPD modeling has become a standard requirement for the regulatory approval of a drug.
Yet new concepts continue to emerge. The most recent developments in pharmacology are directed to the interfacing with systems biology. Novel Systems Pharmacology concepts are introduced, which yield a scientific basis for the design, the development and the clinical usage of 'precision treatments' aimed at disease modification.