Universiteit Leiden

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Leiden Academic Centre for Drug Research


Honorary symposium Prof. dr. M. Danhof: Four decades of Research in Pharmacokinetics, Pharmacodynamics and beyond...", Leiden, 31 March 2017

About this symposium:

This 'Farewell symposium' will celebrate Prof. dr. M. Danhof's professional career and all the high level contributions he has made to the area of Pharmacology. The symposium will be followed by the farewell lecture of Professor Danhof and a reception.










The symposium and farewell lecture require seperate registration each:

Registration is free of charge. The registration will be closed on the 1st of March 2017.

In the case you are unfortunately not be able to attend the symposium after registration, please let us know!

Hotel accommodation

Hotel accommodation is not included. It is possible to book hotel accommodation at the Golden Tulip Leiden for a university rate. Please contact the hotel and mention reservation number 199282.


Symposium Program, Stadsgehoorzaal


  • Prof. dr. Douwe Breimer - Leiden University, NL

  • Prof. dr. Catherijne Knibbe - Antonious Hospital Nieuwegein / Leiden University, NL


09:00 - 09:30   Welcome with coffee & tea at "Stadsgehoorzaal"

09:30 - 09:40   Introduction pharmacokinetics - pharmacodynamics research at Leiden University

Douwe Breimer - Leiden University, NL

09:40 - 10:00   Pharmacokinetics: from physiologically-based models to compartmental models and back!

Amin Rostami - University of Manchester, UK

10:00 - 10:20   Targeting the CNS; translational research approaches

Elizabeth de Lange - Leiden University, NL

10:20 - 10:40   Measuring and modeling pharmacological drug effect: Mission Accomplished!!!

Don Stanski - AstraZeneca, USA

10:40 - 11:10   COFFEE BREAK

11:10 - 11:30   Quantitative translational pharmacology: connecting pharmacokinetics, dynamics and receptor theory

Piet Hein van der Graaf - Leiden University, NL/Certara, UK

11:30 - 11:50   Drug development as easy as (phase) I II III IV ? Time for disruption!

Adam Cohen - Center for Human Drug Research (CHDR), NL

11:50 - 12:10   Drug action in developing biological systems- clinical pharmacology in pediatrics

Sander Vinks - University of Cincinnati, USA

12:10 - 13:30   LUNCH

13:30 - 13:50   Disease and disease progression

Nick Holford - University of Auckland NZL

13:50 - 14:10   Open innovation: towards the sharing of data, models and workflows

Mats Karlsson - Uppsala University, SWE

14:10 - 14:30   Towards systems pharmacology

Don Mager - University of Buffalo, USA

14:30 - 14:50   Precision medicine in clinical practice

Henk Jan Guchelaar - Leiden University Medical Center (LUMC), NL

14:50 - 15:15   COFFEE BREAK

Farewell Lecture, 'Academiegebouw'

15:15 - 15:45   Walk to "Academiegebouw"

16:00 - 17:00   Farewell Lecture: Reflections on pharmacology - Four decades of pharmacokinetics-pharmacodynamics research at Leiden University

Meindert Danhof

17:00 - 18:30   Reception


For questions: symposium@lacdr.leidenuniv.nl


Reflections on pharmacology: 'Pharmacokinetics & Pharmacodynamics' en route to 'Systems Pharmacology'


Over the years pharmacology has contributed important pharmacokinetic (PK) and pharmacodynamic (PD) modeling concepts that are widely utilized in drug discovery & development research and in clinical practice. At this symposium we will review the established as well as the emerging novel concepts in pharmacology.

At the level of the pharmacodynamics, between 1960 to 1970, the development of receptor theory concepts has yielded the basis for the understanding of in vivo drug-concentration-effect relations. Next, in particular progress in the pharmacokinetics has been the source of novel concepts. Major achievements in pharmacokinetics include:

  1. the elucidation of the molecular mechanisms of drug disposition (i.e. drug metabolizing enzymes and transporters),
  2. the development of pharmacokinetic modeling concepts including the introduction of physiology-based pharmacokinetic (PBPK) modeling for the prediction of in vivo drug concentration profiles,
  3. the identification of inter-individual variation in drug disposition as the basis for variation in drug response (and the introduction of the concepts of “population” pharmacokinetics), and
  4. the introduction of pharmacokinetic-pharmacodynamic modeling (PKPD) concepts as the basis for prediction of the time course of drug effects.

Nowadays pharmacokinetic and pharmacodynamic modeling concepts are routinely used as the basis for the development of new drugs. Moreover PKPD modeling has become a standard requirement for the regulatory approval of a drug.

Yet new concepts continue to emerge. The most recent developments in pharmacology are directed to the interfacing with systems biology. Novel Systems Pharmacology concepts are introduced, which yield a scientific basis for the design, the development and the clinical usage of 'precision treatments' aimed at disease modification.