At the division of Medicinal Chemistry we want to understand drug action at ‘high resolution’, thus at an almost atomic level.
We want to use that understanding for a more rational approach to drug design. We have chosen the most important class of drug targets to work on, the G protein-coupled receptors (GPCRs). Close to 30% of all medicines work via these targets in our body.
Ambitions (yes, we’re ambitious …)
We pursue a ‘chemical biology’ approach, in which we combine synthetic chemistry, new developments in the world of informatics and computer science (bioinformatics, cheminformatics), and both biochemistry/molecular biology and pharmacology.
This is quite ideal, as we now have all the necessary ingredients to come up with ideas for new drugs, to make them, and to see how they work.
Example: Parkinson and CoffeeAs an example, please, read more about the four fascinating adenosine receptors. One may help to cure Parkinson’s disease,
but most are involved in the actions of caffeine… Read more >>